Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".

scientific article

Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation". is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JMB.2003.12.005
P698PubMed publication ID14741214

P50authorAlan FershtQ537479
P2093author name stringAssaf Friedler
Stefan M V Freund
Stefan Rüdiger
Brian S DeDecker
Caroline Blair
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)187-196
P577publication date2004-02-01
P1433published inJournal of Molecular BiologyQ925779
P1476titleStructural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".
P478volume336

Reverse relations

cites work (P2860)
Q56341291Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer
Q51564147Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic binding site in p53.
Q34412989Biopharmaceuticals and monoclonal antibodies in oncology trials--a cross-sectional analysis
Q38472585Compensated pathogenic deviations
Q50051527Different TP53 mutants in p53 overexpressed epithelial ovarian carcinoma can be associated both with altered and unaltered glycolytic and apoptotic profiles
Q92293773Efficient Modulation of TP53 Expression in Human Induced Pluripotent Stem Cells
Q37808312From peptides to proteins: lessons from my years at the Centre for Protein Engineering
Q84551753Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions
Q47789753Insights into the Effect of the G245S Single Point Mutation on the Structure of p53 and the Binding of the Protein to DNA.
Q41677793Multisite aggregation of p53 and implications for drug rescue
Q57950380Mutants of the tumour suppressor p53 L1 loop as second-site suppressors for restoring DNA binding to oncogenic p53 mutations: structural and biochemical insights
Q44145204QM-MM simulations on p53-DNA complex: a study of hot spot and rescue mutants
Q30009903Regulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism
Q36710840Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.
Q33795918SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53
Q58740843Skeletal Muscle Dystrophy mutant of lamin A alters the structure and dynamics of the Ig fold domain
Q33322204Stability of the core domain of p53: insights from computer simulations
Q36786022Structural biology of the tumor suppressor p53 and cancer-associated mutants
Q35051686Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain
Q36777367Structure-function-rescue: the diverse nature of common p53 cancer mutants
Q45259201Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations
Q37855887Using peptides to study protein-protein interactions
Q36764842p53 gene in treatment of hepatic carcinoma: status quo.

Search more.