Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling.

scientific article

Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/ATVBAHA.117.309571
P932PMC publication ID5785447
P698PubMed publication ID29284606

P50authorRadu V StanQ52351627
Elisabetta DejanaQ56099781
Chase H MelickQ89531620
P2093author name stringBrant M Weinstein
Daniel Castranova
Amber N Stratman
Matteo Malinverno
Shlomo Krispin
Jamie Gleklen
P2860cites workA single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cellsQ24291278
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartmentsQ24299236
Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasiaQ24302138
Functionally specialized junctions between endothelial cells of lymphatic vesselsQ24676415
GDF6, a novel locus for a spectrum of ocular developmental anomaliesQ24680270
Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryosQ27348907
VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherinQ28116308
The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migrationQ28250994
Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesisQ28266349
Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndromeQ28277217
BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesisQ28289169
Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypesQ28306123
VE-cadherin is a critical endothelial regulator of TGF-beta signallingQ28594650
Molecular regulation of angiogenesis and lymphangiogenesisQ29616150
VEGF receptor signalling - in control of vascular functionQ29617256
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluidQ29617640
Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activationQ30497938
Genetic defects of GDF6 in the zebrafish out of sight mutant and in human eye developmental anomaliesQ33744524
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II geneQ34142690
Endothelial cell migration during angiogenesisQ34613912
Maternal induction of ventral fate by zebrafish radarQ34868942
Heterozygous null bone morphogenetic protein receptor type 2 mutations promote SRC kinase-dependent caveolar trafficking defects and endothelial dysfunction in pulmonary arterial hypertensionQ34958933
High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6.Q35668755
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.Q35832692
Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivoQ36445579
Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressionsQ36771343
Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescenceQ37080802
An essential role for Radar (Gdf6a) in inducing dorsal fate in the zebrafish retinaQ37114779
Unveiling the bmp13 enigma: redundant morphogen or crucial regulator?Q37271457
The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implicationsQ37393194
BMP signaling in vascular diseasesQ38019702
Endothelial adherens junctions at a glanceQ38115518
VE-cadherin and endothelial adherens junctions: active guardians of vascular integrityQ38138649
Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function.Q38830951
Molecular mechanisms regulating ocular apoptosis in zebrafish gdf6a mutantsQ43588682
Pathophysiological consequences of VEGF-induced vascular permeabilityQ46349878
Radar is required for the establishment of vascular integrity in the zebrafishQ47073258
Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site.Q51804915
Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity.Q54441527
Activin receptor-like kinase 1 inhibits human microvascular endothelial cell migration: Potential roles for JNK and ERKQ58336647
Angiogenic network formation in the developing vertebrate trunkQ73898704
Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesisQ77808299
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectGrowth differentiation factor 6aQ29822049
P304page(s)353-362
P577publication date2017-12-28
P1433published inArteriosclerosis, Thrombosis, and Vascular BiologyQ4797542
P1476titleGrowth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling
P478volume38

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cites work (P2860)
Q52624116Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules.
Q50422421Vascular Development

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