Synergistic role of 5-azacytidine and ascorbic acid in directing cardiosphere derived cells to cardiomyocytes in vitro by downregulating Wnt signaling pathway via phosphorylation of β-catenin.

scientific article published on 30 November 2017

Synergistic role of 5-azacytidine and ascorbic acid in directing cardiosphere derived cells to cardiomyocytes in vitro by downregulating Wnt signaling pathway via phosphorylation of β-catenin. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0188805
P932PMC publication ID5708695
P698PubMed publication ID29190771

P50authorAnuradha DhanasekaranQ89442678
P2093author name stringYamini Chandramohan
Nitin Khatri
Sanjana Vig
Pavani Koka
Prakash Dhanaraj
Reddy Sailaja Mundre
P2860cites workHuman cardiac stem cells exhibit mesenchymal features and are maintained through Akt/GSK-3beta signalingQ79409654
In vitro cardiomyogenic differentiation of adult human bone marrow mesenchymal stem cells. The role of 5-azacytidineQ80725072
Isolation and expansion of adult cardiac stem cells from human and murine heartQ80837204
Beta-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cellsQ81470072
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-cateninQ24313571
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactorsQ24314957
NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytesQ24315020
Erythropoietin protects cardiomyocytes from cell death during hypoxia/reperfusion injury through activation of survival signaling pathwaysQ27347504
Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathwayQ28217024
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineagesQ28306800
Expression and Localization of Opioid Receptors in Male Germ Cells and the Implication for Mouse SpermatogenesisQ28551105
beta-catenin is a target for the ubiquitin-proteasome pathwayQ29547589
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trialQ29620043
Adult cardiac stem cells are multipotent and support myocardial regenerationQ29620122
Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytesQ30909818
Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivoQ33270812
Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissueQ33506639
Cardiomyocytes can be generated from marrow stromal cells in vitroQ33843659
A cocktail method for promoting cardiomyocyte differentiation from bone marrow-derived mesenchymal stem cellsQ33891391
Transplantation of cardiac progenitor cell sheet onto infarcted heart promotes cardiogenesis and improves functionQ33906844
Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidineQ34418477
Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart AssociationQ34505315
Cardiac resynchronization by cardiosphere-derived stem cell transplantation in an experimental model of myocardial infarction.Q35068789
5-Azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinaseQ35632731
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cellsQ35799278
Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cellsQ35808417
A role for chemistry in stem cell biologyQ35824092
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Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cellsQ35958815
Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarctionQ36349782
Beta-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation.Q37018900
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Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repairQ37557881
WNT signaling in adult cardiac hypertrophy and remodeling: lessons learned from cardiac developmentQ37808905
Progenitor cells isolated from the human heart: a potential cell source for regenerative therapy.Q39266763
Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cellsQ39670905
Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia.Q39681091
WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1.Q39929872
The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processesQ40399652
Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing Their Enhanced Functional Potency for Myocardial RepairQ42251376
Effect of 5-azacytidine induction duration on differentiation of human first-trimester fetal mesenchymal stem cells towards cardiomyocyte-like cellsQ43270064
Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarctionQ46259595
Ascorbic acid enhances adipogenesis of bone marrow-derived mesenchymal stromal cellsQ46391913
Effect of ascorbic acid on bone marrow-derived mesenchymal stem cell proliferation and differentiationQ46473751
Cardiac differentiation is driven by NKX2.5 and GATA4 nuclear translocation in tissue-specific mesenchymal stem cellsQ47254613
Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens.Q48414650
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e0188805
P577publication date2017-11-30
P1433published inPLOS OneQ564954
P1476titleSynergistic role of 5-azacytidine and ascorbic acid in directing cardiosphere derived cells to cardiomyocytes in vitro by downregulating Wnt signaling pathway via phosphorylation of β-catenin
P478volume12

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cites work (P2860)
Q92637710Supporting Cell-Based Tendon Therapy: Effect of PDGF-BB and Ascorbic Acid on Rabbit Achilles Tenocytes in Vitro
Q58108789Why SNP rs227584 is associated with human BMD and fracture risk? A molecular and cellular study in bone cells

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