A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities

scientific article published on 13 December 2017

A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities is …
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scholarly articleQ13442814

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P356DOI10.1016/J.YEXCR.2017.12.010
P698PubMed publication ID29247619

P50authorLuca Lo PiccoloQ51085001
Salinee JantrapiromQ57317322
P2093author name stringHideki Yoshida
Masamitsu Yamaguchi
P2860cites workThe ubiquilin gene family: evolutionary patterns and functional insightsQ21283993
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulationQ24290515
Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domainsQ24293422
Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell deathQ24300869
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementiaQ24600027
Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradationQ24653719
Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisQ26863439
Affinity Makes the Difference: Nonselective Interaction of the UBA Domain of Ubiquilin-1 with Monomeric Ubiquitin and Polyubiquitin ChainsQ27649753
The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasomeQ28138493
Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequencesQ28143308
Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membraneQ28146189
GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1Q28214808
Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteinsQ28248771
Neuroarchitecture of aminergic systems in the larval ventral ganglion of Drosophila melanogasterQ33325471
Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in DrosophilaQ33346273
USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through UbiquilinQ33708223
A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like StchQ33890149
Rad23 promotes the targeting of proteolytic substrates to the proteasomeQ34283029
Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS MutationsQ35663774
Drosophila models of proteinopathies: the little fly that couldQ35791494
Optimization of wrMTrck to monitor Drosophila larval locomotor activityQ36080563
Development of Drosophila motoneurons: specification and morphologyQ36342926
Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansionQ36464731
Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutationsQ37451158
TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathiesQ37904288
Regulated protein aggregation: stress granules and neurodegenerationQ38060891
Proteostasis and agingQ38662553
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Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretionQ40237384
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Neuropeptides, amines and amino acids in an elementary insect ganglion: functional and chemical anatomy of the unfused abdominal ganglionQ41109466
A connectome of a learning and memory center in the adult Drosophila brainQ41329990
Ubiquilin at a crossroads in protein degradation pathwaysQ42152457
The Role of Histone Deacetylase 6 in Synaptic Plasticity and MemoryQ42292318
Together, Rpn10 and Dsk2 can serve as a polyubiquitin chain-length sensorQ42936102
ubiquilin antagonizes presenilin and promotes neurodegeneration in DrosophilaQ43442095
Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studiesQ44120968
dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes.Q45954525
Ubiquilin 2 mutations in Italian patients with amyotrophic lateral sclerosis and frontotemporal dementiaQ46409003
Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genesQ47070160
Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunitQ47071242
Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behaviorQ47071494
Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.Q47071929
Neuron-specific knockdown of the Drosophila fat induces reduction of life span, deficient locomotive ability, shortening of motoneuron terminal branches and defects in axonal targeting.Q47727633
Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domainQ47857312
RNAi of arcRNA hsrω affects sub-cellular localization of Drosophila FUS to drive neurodiseases.Q51084949
Novel UBQLN2 mutations linked to amyotrophic lateral sclerosis and atypical hereditary spastic paraplegia phenotype through defective HSP70-mediated proteolysis.Q51809260
Precise control of fasciclin II expression is required for adult mushroom body development in Drosophila.Q51990440
Full genome screen for Alzheimer disease: Stage II analysisQ56769992
p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALSQ58477808
Drosophila – a versatile model in biology & medicineQ60043338
Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutionsQ72153709
The DNA repair protein rad23 is a negative regulator of multi-ubiquitin chain assemblyQ74298282
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
Ubiquilin Dmel_CG14224Q29809121
P304page(s)461-471
P577publication date2017-12-13
P1433published inExperimental Cell ResearchQ1524289
P1476titleA new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities
P478volume362