Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment.

scientific article published on 11 December 2017

Synaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41593-017-0037-5
P932PMC publication ID5742540
P698PubMed publication ID29230057

P50authorThorsten TrimbuchQ56960887
Christian RosenmundQ33274633
P2093author name stringShuwen Chang
P2860cites workMechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanismQ22061733
The synaptic vesicle cycleQ24297813
Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosisQ26269821
Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solutionQ26269828
Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans.Q52535811
Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila.Q52565810
The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.Q52597582
Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I.Q54459561
PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane.Q55038004
Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor ComplexesQ56992446
Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensorQ64375154
Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic VesiclesQ26269831
Neurotransmitter release: the last millisecond in the life of a synaptic vesicleQ26269845
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous releaseQ26269916
Molecular machines governing exocytosis of synaptic vesiclesQ26849286
Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machineQ27637071
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitmentQ27678096
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding foldQ27729921
How synaptotagmin promotes membrane fusion.Q27863355
Synaptotagmin I functions as a calcium regulator of release probabilityQ28204147
The morphological and molecular nature of synaptic vesicle priming at presynaptic active zonesQ28506683
A common molecular basis for membrane docking and functional priming of synaptic vesiclesQ28512083
Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusionQ28584744
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapseQ28587672
Proteolysis of SNAP-25 by types E and A botulinal neurotoxinsQ28609208
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectorsQ29547596
Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevinQ29619130
Definition of the readily releasable pool of vesicles at hippocampal synapsesQ29620402
Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I.Q33465411
Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junctionQ34207383
Protein-Lipid Interplay in Fusion and Fission of Biological MembranesQ34267537
Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleationQ35089488
Presynaptic calcium and control of vesicle fusionQ36140944
The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.Q36983031
Prevalent mechanism of membrane bridging by synaptotagmin-1.Q37117899
Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopyQ37265752
Ultrafast endocytosis at mouse hippocampal synapses.Q37642826
The top loops of the C(2) domains from synaptotagmin and phospholipase A(2) control functional specificityQ38299112
The Mechanisms and Functions of Synaptic FacilitationQ39284166
Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansionQ41413294
Sequential SNARE assembly underlies priming and triggering of exocytosis.Q43601412
Dual roles of the C2B domain of synaptotagmin I in synchronizing Ca2+-dependent neurotransmitter release.Q45084937
Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivoQ46083214
A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin CellsQ48116269
Synaptotagmin: a calcium sensor on the synaptic vesicle surfaceQ48480063
Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers.Q50524047
Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1.Q51808788
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)33-40
P577publication date2017-12-11
P1433published inNature NeuroscienceQ1535359
P1476titleSynaptotagmin-1 drives synchronous Ca2+-triggered fusion by C2B-domain-mediated synaptic-vesicle-membrane attachment
P478volume21

Reverse relations

cites work (P2860)
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Q100316419Synaptic vesicles transiently dock to refill release sites
Q90002517Synaptotagmin 1 clamps synaptic vesicle fusion in mammalian neurons independent of complexin
Q89517800Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release
Q92432002Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner
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