Host cell perforation by listeriolysin O (LLO) activates a Ca2+-dependent cPKC/Rac1/Arp2/3 signaling pathway that promotes L. monocytogenes internalization independently of membrane resealing

scientific article published on 29 November 2017

Host cell perforation by listeriolysin O (LLO) activates a Ca2+-dependent cPKC/Rac1/Arp2/3 signaling pathway that promotes L. monocytogenes internalization independently of membrane resealing is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1091/MBC.E17-09-0561
P932PMC publication ID5996962
P698PubMed publication ID29187576

P50authorStephen VadiaQ61090132
P2093author name stringStephanie Seveau
Xiaoli Zhang
Jonathan G T Lam
Sarika Pathak-Sharma
Eric McLaughlin
Joel Swanson
P2860cites workEntry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigens from gram-positive cocciQ48221371
Identification of the epidermal growth factor receptor as the receptor for Salmonella Rck-dependent invasion.Q49962051
Rho GTPases and their role in organizing the actin cytoskeleton.Q54612905
Entry of Listeria monocytogenes into hepatocytes requires expression of inIB, a surface protein of the internalin multigene familyQ71757047
The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytesQ21089605
The cell surface environment for pathogen recognition and entryQ24289355
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase CQ24675024
Manipulation of host membranes by the bacterial pathogens Listeria, Francisella, Shigella and YersiniaQ26742013
Cytosolic Access of Intracellular Bacterial Pathogens: The Shigella ParadigmQ26752427
Multifaceted activity of listeriolysin O, the cholesterol-dependent cytolysin of Listeria monocytogenesQ26864252
Generation of membrane structures during phagocytosis and chemotaxis of macrophages: role and regulation of the actin cytoskeletonQ26865586
Damage control: cellular mechanisms of plasma membrane repairQ27022016
Listeria monocytogenes internalin B activates junctional endocytosis to accelerate intestinal invasionQ27314798
A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosisQ27335399
Rho GTPases in cell biologyQ27860969
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5Q28303765
Rho GTPases and signaling networksQ28646215
The MACPF/CDC family of pore-forming toxinsQ30157659
Pattern formation of Rho GTPases in single cell wound healingQ30534505
Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediateQ31645688
Adenovirus internalization and infection require dynaminQ33783549
Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repairQ33916052
Endocytosis of viruses and bacteriaQ33938568
Listeria pathogenesis and molecular virulence determinantsQ33975740
Role of listeriolysin O in cell-to-cell spread of Listeria monocytogenesQ34003416
Fluorescence resonance energy transfer-based stoichiometry in living cellsQ34179589
Bacterial invasion: the paradigms of enteroinvasive pathogensQ34312229
Rho GTPases and the control of cell behaviourQ34462373
Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasionQ34973755
PI3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenesQ35064911
Role of lipid-mediated signal transduction in bacterial internalization.Q35114079
How bacterial pathogens colonize their hosts and invade deeper tissuesQ35552432
Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysinQ35669797
Membrane Repair: Mechanisms and Pathophysiology.Q36146335
Role of lipid rafts in E-cadherin-- and HGF-R/Met--mediated entry of Listeria monocytogenes into host cellsQ36322535
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytesQ36380848
Multiplicity of Salmonella entry mechanisms, a new paradigm for Salmonella pathogenesis.Q36395663
Listeria monocytogenes: a multifaceted modelQ36482507
Repair of injured plasma membrane by rapid Ca2+-dependent endocytosisQ36491740
Molecular mechanisms exploited by Listeria monocytogenes during host cell invasionQ36924633
Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational changeQ36935603
Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis.Q37031442
The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggsQ37101721
Molecular mechanisms of phagocytic uptake in mammalian cells.Q37103162
Actin nucleation and elongation factors: mechanisms and interplayQ37164608
Caveolae internalization repairs wounded cells and muscle fibers.Q37181157
Common themes in the design and function of bacterial effectorsQ37312444
Fluxes of Ca2+ and K+ are required for the listeriolysin O-dependent internalization pathway of Listeria monocytogenes.Q37643817
Manipulation of host membranes by bacterial effectorsQ37902048
Pathways for the penetration of enteroinvasive Yersinia into mammalian cellsQ37914725
Gulping rather than sipping: macropinocytosis as a way of virus entryQ38022965
Cell signaling during Trypanosoma cruzi invasionQ38066485
Host Serine/Threonine Kinases mTOR and Protein Kinase C-α Promote InlB-Mediated Entry of Listeria monocytogenesQ38705267
Co-option of Membrane Wounding Enables Virus Penetration into Cells.Q39193544
Plasma membrane repair: the adaptable cell life-insuranceQ39311535
Listeriolysin O: from bazooka to Swiss army knife.Q39384373
Genetically encoded fluorescent reporters to visualize protein kinase C activation in live cellsQ39484039
Pore-forming toxins induce multiple cellular responses promoting survival.Q39553466
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases.Q39581979
Intramolecular conformational changes optimize protein kinase C signalingQ39606803
Rck of Salmonella enterica, subspecies enterica serovar enteritidis, mediates zipper-like internalization.Q39718726
Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells.Q40063973
High-Throughput Microplate-Based Assay to Monitor Plasma Membrane Wounding and RepairQ40108936
Localization of protein kinase C epsilon to macrophage vacuoles perforated by Listeria monocytogenes cytolysinQ40161818
Extracellular amastigotes of Trypanosoma cruzi are potent inducers of phagocytosis in mammalian cellsQ40172156
Intermedilysin is essential for the invasion of hepatoma HepG2 cells by Streptococcus intermediusQ40395173
Protein kinase C Signaling in Adenoviral InfectionQ40517696
Host cell actin polymerization is required for cellular retention of Trypanosoma cruzi and early association with endosomal/lysosomal compartmentsQ40531979
The Intracellular Domain of the Coxsackievirus and Adenovirus Receptor Differentially Influences Adenovirus Entry.Q40774340
InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinaseQ40841869
Calcium signaling regulates translocation and activation of Rac.Q42798776
Quantification of host-microbe interactions by automated fluorescence microscopyQ43938083
E-cadherin is the receptor for internalin, a surface protein required for entry of L. monocytogenes into epithelial cellsQ45345430
P433issue3
P304page(s)270-284
P577publication date2017-11-29
P1433published inMolecular Biology of the CellQ2338259
P1476titleHost cell perforation by listeriolysin O (LLO) activates a Ca2+-dependent cPKC/Rac1/Arp2/3 signaling pathway that promotes L. monocytogenes internalization independently of membrane resealing
P478volume29

Reverse relations

cites work (P2860)
Q90390464A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates
Q97592235A listeriolysin O subunit vaccine is protective against Listeria monocytogenes
Q58694110Functional Consequences of Calcium Influx Promoted by Bacterial Pore-Forming Toxins
Q91961684Phobalysin: Fisheye View of Membrane Perforation, Repair, Chemotaxis and Adhesion
Q101409915Plasmodium translocon component EXP2 facilitates hepatocyte invasion
Q58702732Relative Roles of Listeriolysin O, InlA, and InlB in Listeria monocytogenes Uptake by Host Cells

Search more.