Application of Pharmacokinetics Modelling to Predict Human Exposure of a Cationic Liposomal Subunit Antigen Vaccine System.

scientific article published on 7 December 2017

Application of Pharmacokinetics Modelling to Predict Human Exposure of a Cationic Liposomal Subunit Antigen Vaccine System. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/PHARMACEUTICS9040057
P932PMC publication ID5750663
P698PubMed publication ID29215597

P50authorRaj K S BadhanQ56422380
P2093author name stringSwapnil Khadke
Yvonne Perrie
P2860cites workLiposomal cationic charge and antigen adsorption are important properties for the efficient deposition of antigen at the injection site and ability of the vaccine to induce a CMI responseQ57955486
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Pegylation of DDA:TDB liposomal adjuvants reduces the vaccine depot effect and alters the Th1/Th2 immune responsesQ82234204
A physiologically-based pharmacokinetic (PBPK) model of squalene-containing adjuvant in human vaccinesQ39373123
The investigation of capillary permeability in single vesselsQ39804900
Scale-up of a physiologically-based pharmacokinetic model to predict the disposition of monoclonal antibodies in monkeysQ40545249
Physiological parameter values for physiologically based pharmacokinetic modelsQ41556435
Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn ModelQ41559765
Liposomes based on dimethyldioctadecylammonium promote a depot effect and enhance immunogenicity of soluble antigenQ43252469
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Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteersQ45233558
Comparison of rabbit and mouse models for persistence analysis of plasmid-based vaccinesQ46986963
Manipulation of the surface pegylation in combination with reduced vesicle size of cationic liposomal adjuvants modifies their clearance kinetics from the injection site, and the rate and type of T cell responseQ47297457
The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production.Q47373276
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Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.Q52379785
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Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeabilityQ34083937
Simulation of monoclonal antibody pharmacokinetics in humans using a minimal physiologically based modelQ34099756
Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responsesQ34217826
Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trialQ34663035
Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activationQ34920323
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Increased lymphangiogenesis in joints of mice with inflammatory arthritisQ36465469
Combination of the cationic surfactant dimethyl dioctadecyl ammonium bromide and synthetic mycobacterial cord factor as an efficient adjuvant for tuberculosis subunit vaccinesQ36576750
The pharmacokinetics and pharmacodynamics of monoclonal antibodies--mechanistic modeling applied to drug development.Q36723559
A case-study investigating the physicochemical characteristics that dictate the function of a liposomal adjuvantQ38098855
Radiolabelling of Antigen and Liposomes for Vaccine Biodistribution StudiesQ38753321
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P577publication date2017-12-07
P1433published inPharmaceuticsQ27723332
P1476titleApplication of Pharmacokinetics Modelling to Predict Human Exposure of a Cationic Liposomal Subunit Antigen Vaccine System
P478volume9

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