Current and future therapeutic approaches for osteosarcoma.

scientific article published on 6 December 2017

Current and future therapeutic approaches for osteosarcoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/14737140.2018.1413939
P698PubMed publication ID29210294

P50authorRichard G GorlickQ56427012
P2093author name stringDavid S Geller
Valerae O Lewis
Douglas J Harrison
Jonathan D Gill
P2860cites workA comparative study between limb-salvage and amputation for treating osteosarcomaQ26753095
Osteosarcoma: Current Treatment and a Collaborative Pathway to SuccessQ26797555
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesisQ29617585
Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good RQ30357731
Compress knee arthroplasty has 80% 10-year survivorship and novel forms of bone failureQ30534456
Intensive Induction Chemotherapy without Methotrexate in Adult Patients with Localized Osteosarcoma: Results of the Institut Gustave-Roussy Phase II TrialQ33393253
Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results ProgramQ33406382
Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial.Q33419286
Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial.Q33434899
Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathwaysQ33582914
Metastases detected at the time of diagnosis of primary pediatric extremity osteosarcoma at diagnosis: imaging featuresQ33753959
Cemented distal femoral endoprostheses for musculoskeletal tumor: improved survival of modular versus custom implantsQ33956306
Osteosarcoma treatment - where do we stand? A state of the art review.Q34392457
Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate.Q34404179
Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.Q34413741
Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651.Q34532932
Preoperative chemotherapy for osteogenic sarcoma:Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapyQ39340821
Human osteosarcoma cells express functional receptor activator of nuclear factor-kappa B.Q40166492
Primary Osteosarcoma of Bone: A Clinicopathologic Investigation of 243 Cases, with Necropsy Studies in 54Q40484531
Retrospective evaluation of the incidence of early periprosthetic infection with silver-treated endoprostheses in high-risk patients: case-control studyQ41517963
Long-term follow-up and post-relapse survival in patients with non-metastatic osteosarcoma of the extremity treated with neoadjuvant chemotherapy.Q41613919
Computer-assisted surgery in orthopedic oncologyQ41887178
Surgical technique: Computer-generated custom jigs improve accuracy of wide resection of bone tumorsQ41904238
Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacyQ41983246
Randomized trial of the cardioprotective agent ICRF-187 in pediatric sarcoma patients treated with doxorubicinQ42556370
Surgical guides (patient-specific instruments) for pediatric tibial bone sarcoma resection and allograft reconstructionQ43223770
Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery?Q44202173
Endoprosthetic reconstruction for the treatment of musculoskeletal tumors of the appendicular skeleton and pelvisQ47667534
Navigated pelvic osteotomy and tumor resection: a study assessing the accuracy and reproducibility of resection planes in Sawbones and cadaversQ48690737
CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of osteosarcoma patients: An immunohistochemical analysis of the biopsies fromthe French OS2006 phaQ50481939
The use of massive bone allograft with intramedullary free fibular flap for limb salvage in a pediatric and adolescent populationQ51154694
Segmental femur reconstruction using an intercalary allograft with an intramedullary vascularized fibula bone flapQ51688208
Can computer navigation-assisted surgery reduce the risk of an intralesional margin and reduce the rate of local recurrence in patients with a tumour of the pelvis or sacrum?Q53093915
Skeletal reconstruction with a free vascularized fibula graft associated to bone allograft after resection of malignant bone tumor of limbsQ53887029
Local recurrence and local control of non-metastatic osteosarcoma of the extremities: a 27-year experience in a single institutionQ56994814
RANKL expression is related to treatment outcome of patients with localized, high‐grade osteosarcomaQ57226639
Use of a patient-specific CAD/CAM surgical jig in extremity bone tumor resection and custom prosthetic reconstructionQ58493680
International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly personsQ34605959
A phase II trial of sorafenib in relapsed and unresectable high-grade osteosarcoma after failure of standard multimodal therapy: an Italian Sarcoma Group studyQ34628840
Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival--a report from the Children's Oncology GroupQ34743615
Ganglioside GD2 expression is maintained upon recurrence in patients with osteosarcomaQ35030373
What was the survival of megaprostheses in lower limb reconstructions after tumor resections?Q35050283
Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcomaQ35624496
Biology and therapeutic advances for pediatric osteosarcomaQ35841976
Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Group: Learning From the Past to Move ForwardQ36072962
Germline TP53 variants and susceptibility to osteosarcoma.Q36294747
Survival trends and long-term toxicity in pediatric patients with osteosarcoma.Q36440294
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trialQ36503647
Haptic robot-assisted surgery improves accuracy of wide resection of bone tumors: a pilot studyQ36585992
Future directions in the treatment of osteosarcoma.Q36600800
Intensified Chemotherapy With Dexrazoxane Cardioprotection in Newly Diagnosed Nonmetastatic Osteosarcoma: A Report From the Children's Oncology Group.Q36653789
A review of clinical and molecular prognostic factors in osteosarcomaQ36983787
Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcomaQ37125088
Initial testing (stage 1) of the multi-targeted kinase inhibitor sorafenib by the pediatric preclinical testing programQ37295112
Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology GroupQ37439345
Assessing the Prognostic Significance of Histologic Response in Osteosarcoma: A Comparison of Outcomes on CCG-782 and INT0133-A Report From the Children's Oncology Group Bone Tumor Committee.Q37471124
Response to anti-PD1 therapy with nivolumab in metastatic sarcomas.Q37545590
Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-grade osteosarcoma: a rationale for T-cell-based immunotherapyQ37575208
Ganglioside GD2 as a therapeutic target for antibody-mediated therapy in patients with osteosarcoma.Q37624276
The role of interferons in the treatment of osteosarcomaQ37630430
Osteosarcoma: review of the past, impact on the future. The American experienceQ37705055
Osteosarcoma: the COSS experienceQ37705062
Palliative therapy for osteosarcoma.Q37845831
Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand?Q37894250
Historical perspective on the introduction and use of chemotherapy for the treatment of osteosarcomaQ38219831
Muramyl tripeptide-phosphatidyl ethanolamine encapsulated in liposomes (L-MTP-PE) in the treatment of osteosarcomaQ38219845
Zoledronate in combination with chemotherapy and surgery to treat osteosarcoma (OS2006): a randomised, multicentre, open-label, phase 3 trialQ38870980
Enhanced T-cell immunity to osteosarcoma through antibody blockade of PD-1/PD-L1 interactions.Q38902256
Development of a Model System to Evaluate Local Recurrence in Osteosarcoma and Assessment of the Effects of Bone Morphogenetic Protein-2.Q38932369
A meta-analysis of randomized control trials of surgical methods with osteosarcoma outcomesQ39086751
The treatment of osteosarcoma of the extremities: twenty year's experience at the Istituto Ortopedico RizzoliQ39240570
P433issue1
P304page(s)39-50
P577publication date2017-12-14
P13046publication type of scholarly workreview articleQ7318358
P1433published inExpert Review of Anticancer TherapyQ2999044
P1476titleCurrent and future therapeutic approaches for osteosarcoma
P478volume18

Reverse relations

cites work (P2860)
Q103831973A Multi-Objective Approach for Anti-Osteosarcoma Cancer Agents Discovery through Drug Repurposing
Q58773880A novel circulating hsa_circ_0081001 act as a potential biomarker for diagnosis and prognosis of osteosarcoma
Q90310234A population-based propensity-matched study of regional dissections in patients with metastatic osteosarcoma
Q91675874Adult Stem Cells for Bone Regeneration and Repair
Q98159042Ailanthone: A novel potential drug for treating human cancer
Q98289244Analysis of changes in the expression of Notch1 and HES1 and the prognosis of osteosarcoma patients following surgery
Q64087780Anti-cancer targets of formononetin and molecular mechanisms in osteosarcoma: Findings of bioinformatic and experimental assays
Q95643038Apatinib ameliorates doxorubicin-induced migration and cancer stemness of osteosarcoma cells by inhibiting Sox2 via STAT3 signalling
Q64296784Bone transport using the Ilizarov method for osteosarcoma patients with tumor resection and neoadjuvant chemotherapy
Q90330859CSN5 controls the growth of osteosarcoma via modulating the EGFR/PI3K/Akt axis
Q98291685Circular RNA circHIPK3 Promotes Cell Metastasis through miR-637/STAT3 Axis in Osteosarcoma
Q60938885Clinical outcomes of patients with primary malignant bone and soft tissue tumor aged 65 years or older
Q90222934Curative-intent radiotherapy for pediatric osteosarcoma: The St. Jude experience
Q90720288Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma
Q55279130Decitabine Enhances Vγ9Vδ2 T Cell-Mediated Cytotoxic Effects on Osteosarcoma Cells via the NKG2DL-NKG2D Axis.
Q92340181Degradation of long non-coding RNA-CIR decelerates proliferation, invasion and migration, but promotes apoptosis of osteosarcoma cells
Q98178384Development of Natural-Based Bone Cement for a Controlled Doxorubicin-Drug Release
Q91634112Down-regulation of LINC00472 promotes osteosarcoma tumorigenesis by reducing FOXO1 expressions via miR-300
Q92408428Early response monitoring of neoadjuvant chemotherapy using [18F]FDG PET can predict the clinical outcome of extremity osteosarcoma
Q64963698Efficacy and safety of apatinib in treatment of osteosarcoma after failed standard multimodal therapy: An observational study.
Q64256698Efficacy of methotrexate, doxorubicin, and cisplatin for osteosarcoma: Study protocol for a systematic review of randomized controlled trial
Q59356084Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors
Q92969709Evaluating and Predicting the Probability of Death in Patients with Non-Metastatic Osteosarcoma: A Population-Based Study
Q58712167Evodiamine Induces Apoptosis, G2/M Cell Cycle Arrest, and Inhibition of Cell Migration and Invasion in Human Osteosarcoma Cells via Raf/MEK/ERK Signalling Pathway
Q91750003Factors influencing survival after recurrence in osteosarcoma: A report from the Children's Oncology Group
Q99619235Flavonoid compound breviscapine suppresses human osteosarcoma Saos-2 progression property and induces apoptosis by regulating mitochondria-dependent pathway
Q57287602GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma
Q92114751Ganoderma lucidum Exerts an Anticancer Effect on Human Osteosarcoma Cells via Suppressing the Wnt/β-Catenin Signaling Pathway
Q90219601Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma
Q64963105Identification of CSPG4 as a promising target for translational combinatorial approaches in osteosarcoma.
Q64104434Improving Magnetofection of Magnetic Polyethylenimine Nanoparticles into MG-63 Osteoblasts Using a Novel Uniform Magnetic Field
Q92835393Influence mechanism of miRNA-144 on proliferation and apoptosis of osteosarcoma cells
Q57028266Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells
Q64275790Innovative Biomaterials for Bone Regrowth
Q89495814Interleukin-22 modulates cisplatin sensitivity of osteosarcoma cells by regulating the STAT3 signaling pathway
Q101052571Knockdown of CircCRIM1 Inhibits HDAC4 to Impede Osteosarcoma Proliferation, Migration, and Invasion and Facilitate Autophagy by Targeting miR-432-5p
Q93182898LINC00514 drives osteosarcoma progression through sponging microRNA-708 and consequently increases URGCP expression
Q64077526LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma
Q64967835LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in osteosarcoma.
Q90435514LncRNA HULC induces the progression of osteosarcoma by regulating the miR-372-3p/HMGB1 signalling axis
Q90447953Long non-coding RNA LINC00152 promotes tumorigenesis via sponging miR-193b-3p in osteosarcoma
Q61806369Low-dose eribulin reduces lung metastasis of osteosarcoma and
Q91896797Metformin Suppresses Self-Renewal Ability and Tumorigenicity of Osteosarcoma Stem Cells via Reactive Oxygen Species-Mediated Apoptosis and Autophagy
Q57494127MiR-1281, a p53-responsive microRNA, impairs the survival of human osteosarcoma cells upon ER stress via targeting USP39
Q89739864MicroRNA-320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element-binding protein 1
Q64083375Non‑covalent proteasome inhibitor PI‑1840 induces apoptosis and autophagy in osteosarcoma cells
Q64261018PDCD5 inhibits osteosarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with good prognosis
Q90616566PTBP1 modulates osteosarcoma chemoresistance to cisplatin by regulating the expression of the copper transporter SLC31A1
Q94526125Piceatannol Suppresses the Proliferation and Induced Apoptosis of Osteosarcoma Cells Through PI3K/AKT/mTOR Pathway
Q90250223Positron Emission Tomography Detects In Vivo Expression of Disialoganglioside GD2 in Mouse Models of Primary and Metastatic Osteosarcoma
Q92711420Prediction of Chemotherapy Response of Osteosarcoma Using Baseline 18F-FDG Textural Features Machine Learning Approaches with PCA
Q90136493Predictors of the Survival of Primary and Secondary Older Osteosarcoma Patients
Q93200198Prognostic Significance of β-Catenin Expression in Osteosarcoma: A Meta-Analysis
Q58572917Progress in the chemotherapeutic treatment of osteosarcoma
Q64121884Risk and clinicopathological features of osteosarcoma metastasis to the lung: A population-based study
Q91789542Sevoflurane Inhibited Osteosarcoma Cell Proliferation And Invasion Via Targeting miR-203/WNT2B/Wnt/β-Catenin Axis
Q89793844Strontium/Chitosan/Hydroxyapatite/Norcantharidin Composite That Inhibits Osteosarcoma and Promotes Osteogenesis In Vitro
Q60919990Targeting the Wnt/β-catenin pathway in human osteosarcoma cells
Q89699693The efficacy and safety comparison of first-line chemotherapeutic agents (high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide) for osteosarcoma: a network meta-analysis
Q57043971Von Willebrand factor rescued by miR-24 inhibition facilitates the proliferation and migration of osteosarcoma cells in vitro
Q60054218WNT6 is an effective marker for osteosarcoma diagnosis and prognosis
Q64376975[Twist regulates proliferation, migration and invasion of osteosarcoma cells in vitro]
Q89939825circPVT1 Facilitates Invasion and Metastasis by Regulating miR-205-5p/c-FLIP Axis in Osteosarcoma
Q92748597miR-1301/TRIAP1 Axis Participates in Epirubicin-Mediated Anti-Proliferation and Pro-Apoptosis in Osteosarcoma
Q92855999miR-495-3p inhibits the cell proliferation, invasion and migration of osteosarcoma by targeting C1q/TNF-related protein 3
Q93165768β-Phenethyl Isothiocyanate Induces Cell Death in Human Osteosarcoma through Altering Iron Metabolism, Disturbing the Redox Balance, and Activating the MAPK Signaling Pathway

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