Acute connexin43 temporal and spatial expression in response to ischemic stroke

scientific article published on 13 November 2017

Acute connexin43 temporal and spatial expression in response to ischemic stroke is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S12079-017-0430-6
P932PMC publication ID5842192
P698PubMed publication ID29134540

P2093author name stringJennifer She
Moises Freitas-Andrade
Christian C Naus
John Bechberger
Wun Chey Sin
P2860cites workNovel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical TreatmentsQ26800178
Cx43 expression and function in the nervous system-implications for stem cell mediated regenerationQ27003327
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Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy.Q31039156
VEGFR-2-mediated increased proliferation and survival in response to oxygen and glucose deprivation in PlGF knockout astrocytesQ33368839
Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion.Q33695548
Pannexin1 knockout and blockade reduces ischemic stroke injury in female, but not in male mice.Q33913803
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytesQ34378150
Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neuronsQ34394699
Fluoro-Jade B staining as useful tool to identify activated microglia and astrocytes in a mouse transgenic model of Alzheimer's diseaseQ34584431
Astrocytes and stroke: networking for survival?Q35074272
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Gap junctions and neurological disorders of the central nervous systemQ35700166
The two pathophysiologies of focal brain ischemia: implications for translational stroke researchQ36079309
Connexin phosphorylation as a regulatory event linked to gap junction channel assemblyQ36162583
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion.Q36912901
How can we improve the pre-clinical development of drugs for stroke?Q36926526
Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transferQ37252611
Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegenerationQ37270004
Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis.Q37301824
Connexin43 phosphorylation: structural changes and biological effectsQ37421795
Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous systemQ37644993
Targeting the ischemic penumbraQ37821638
Astrocytes: targets for neuroprotection in stroke.Q37869174
Heterogeneity in the penumbraQ37897922
Current therapies in ischemic stroke. Part A. Recent developments in acute stroke treatment and in stroke preventionQ37963655
Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond.Q38259555
Snap-frozen brain tissue sections stored with desiccant at ambient laboratory conditions without chemical fixation are resistant to degradation for a minimum of 6 monthsQ38421195
Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1.Q38443014
Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytesQ38736872
Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activityQ39679630
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.Q41131251
Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in miceQ41419929
Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stressQ41876379
Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannelsQ42001061
Astroglial connexin43 hemichannels tune basal excitatory synaptic transmission.Q42464313
Astroglial gap junction communication is increased by treatment with either glutamate or high K+ concentration.Q42490956
Connexin hemichannel blockade improves outcomes in a model of fetal ischemiaQ42633519
Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotectiveQ42947227
Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasiaQ44855767
Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia.Q46852205
Connexin43 null mutation increases infarct size after strokeQ47197115
The antiarrhythmic dipeptide ZP1609 (danegaptide) when given at reperfusion reduces myocardial infarct size in pigsQ47255415
Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemiaQ48091798
Neuroprotective role of astrocytic gap junctions in ischemic strokeQ48113669
A novel method of organotypic brain slice culture using connexin-specific antisense oligodeoxynucleotides to improve neuronal survival.Q48131266
Astrocytic gap junctions composed of connexin 43 reduce apoptotic neuronal damage in cerebral ischemiaQ48262252
Connexin43 hemichannels mediate secondary cellular damage spread from the trauma zone to distal zones in astrocyte monolayers.Q48301481
The connexin43 C-terminal region mediates neuroprotection during stroke.Q48340929
Immunocytochemical localization of tubulin and microtubule-associated protein 2 during the development of hippocampal neurons in culture.Q48371918
Immunorecognition, ultrastructure and phosphorylation status of astrocytic gap junctions and connexin43 in rat brain after cerebral focal ischaemiaQ48388936
Enhanced connexin 43 immunoreactivity in penumbral areas in the human brain following ischemiaQ48456024
The effect of a gap-junction blocker, carbenoxolone, on ischemic brain injury and cortical spreading depression.Q48950769
Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in miceQ49081603
Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury.Q50628456
Astrocytic gap junctional networks suppress cellular damage in an in vitro model of ischemia.Q53082794
Autonomic and myocardial changes in middle cerebral artery occlusion: stroke models in the ratQ69805314
Acute focal ischemia-induced alterations in MAP2 immunostaining: description of temporal changes and utilization as a marker for volumetric assessment of acute brain injuryQ70808964
Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channelsQ83618373
P4510describes a project that usesImageJQ1659584
P433issue1
P304page(s)193-204
P577publication date2017-11-13
P1433published inJournal of Cell Communication and SignalingQ26841964
P1476titleAcute connexin43 temporal and spatial expression in response to ischemic stroke
P478volume12

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cites work (P2860)
Q89943749Danegaptide Enhances Astrocyte Gap Junctional Coupling and Reduces Ischemic Reperfusion Brain Injury in Mice
Q92604773Expression and role of CaMKII and Cx43 in a rat model of post-stroke depression
Q90400196Herbal Compatibility of Ginseng and Rhubarb Exerts Synergistic Neuroprotection in Cerebral Ischemia/Reperfusion Injury of Rats

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