MicroRNA-1 Is Decreased by Hypoxia and Contributes to the Development of Pulmonary Vascular Remodeling via Regulation of Sphingosine Kinase 1.

scientific article published on 22 November 2017

MicroRNA-1 Is Decreased by Hypoxia and Contributes to the Development of Pulmonary Vascular Remodeling via Regulation of Sphingosine Kinase 1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPLUNG.00057.2017
P932PMC publication ID5900352
P698PubMed publication ID29167124

P50authorSuzy A A ComhairQ114735589
P2093author name stringViswanathan Natarajan
Shuangping Zhao
Roberto F Machado
Jiwang Chen
Justin R Sysol
Sunit Singla
P2860cites workInteraction of integrin β4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancementQ24298045
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiationQ24650204
The functions of animal microRNAsQ27860621
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenograftsQ37364840
Pathogenesis of pulmonary arterial hypertension: lessons from cancerQ38167729
Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinaseQ38342964
MicroRNAs in pulmonary arterial hypertension: pathogenesis, diagnosis and treatmentQ38347252
Downregulation of microRNA-1 and microRNA-145 contributes synergistically to the development of colon cancerQ38828506
Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C.Q38927654
Antitumor activity of sphingosine kinase inhibitorsQ40288624
Pim-1: A new biomarker in pulmonary arterial hypertensionQ40303684
Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sitesQ42419115
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphateQ42556020
The cancer paradigm of severe pulmonary arterial hypertensionQ42682888
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.Q42746715
Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1.Q44565276
Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injuryQ44799601
Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family membersQ45211713
Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary vascular remodeling and pulmonary hypertension.Q46004739
BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertensionQ48339689
MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype.Q50300330
MicroRNA-1 regulates the proliferation of vascular smooth muscle cells by targeting insulin-like growth factor 1.Q50320379
Loss of epithelial Gq and G11 signaling inhibits TGFβ production but promotes IL-33-mediated macrophage polarization and emphysema.Q51346034
Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era.Q51556854
Tanshinone IIA promotes pulmonary artery smooth muscle cell apoptosis in vitro by inhibiting the JAK2/STAT3 signaling pathway.Q51730033
Role of Spm-Cer-S1P signalling pathway in MMP-2 mediated U46619-induced proliferation of pulmonary artery smooth muscle cells: protective role of epigallocatechin-3-gallate.Q53305086
Pathogenesis of pulmonary arterial hypertension: the need for multiple hits.Q55040228
Pulmonary Arterial HypertensionQ58485998
MicroRNA-1 inhibits myocardin-induced contractility of human vascular smooth muscle cellsQ28282084
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2Q28295844
Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferationQ28297726
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesisQ29547607
microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart.Q30090181
Pulmonary arterial hypertension: the clinical syndromeQ30583630
MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertensionQ32884516
Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosisQ33756825
Extracellular and Intracellular Actions of Sphingosine-1-PhosphateQ34183703
MicroRNA-directed cleavage of targets: mechanism and experimental approachesQ34389690
Mir-206 regulates pulmonary artery smooth muscle cell proliferation and differentiationQ34447498
Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activityQ34509799
Circulating miRNAs as potential marker for pulmonary hypertensionQ34745818
Pervasive roles of microRNAs in cardiovascular biologyQ34775686
ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American CollQ34977467
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertensionQ34986940
Mitochondrial dynamics in pulmonary arterial hypertensionQ35116543
Arterial smooth muscle cell heterogeneity: implications for atherosclerosis and restenosis developmentQ35195495
MicroRNAs in pulmonary arterial hypertensionQ35207669
CFTR and sphingolipids mediate hypoxic pulmonary vasoconstrictionQ35279508
Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone MetastasisQ35573029
Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth MuscleQ35698710
Treatment of pulmonary arterial hypertensionQ35905944
MiR-1 downregulation correlates with poor survival in clear cell renal cell carcinoma where it interferes with cell cycle regulation and metastasis.Q35955250
IGF-1 signaling in neonatal hypoxia-induced pulmonary hypertension: Role of epigenetic regulationQ36083412
Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1Q36178060
Genomics of microRNA.Q36381610
Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expressionQ36520389
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signalingQ36873593
High levels of hyaluronan in idiopathic pulmonary arterial hypertensionQ36977316
PDGF induces SphK1 expression via Egr-1 to promote pulmonary artery smooth muscle cell proliferationQ37070994
Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1.Q37137690
Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteinsQ37218785
MicroRNAs in pulmonary arterial remodelingQ37308092
P4510describes a project that usesImageJQ1659584
P921main subjectmicroRNAQ310899
microvasculature remodelingQ6840464
P304page(s)ajplung.00057.2017
P577publication date2017-11-22
P1433published inAmerican Journal of Physiology - Lung Cellular and Molecular PhysiologyQ4352992
P1476titleMicroRNA-1 Is Decreased by Hypoxia and Contributes to the Development of Pulmonary Vascular Remodeling via Regulation of Sphingosine Kinase 1.

Reverse relations

cites work (P2860)
Q90279289MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension
Q91754509MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase
Q98770789The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension
Q88538997miR-1 is increased in pulmonary hypertension and downregulates Kv1.5 channels in rat pulmonary arteries
Q64063248miR-1-3p suppresses proliferation of hepatocellular carcinoma through targeting SOX9
Q57129833miR‑760 mediates hypoxia-induced proliferation and apoptosis of human pulmonary artery smooth muscle cells via targeting TLR4