Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides

scientific article published on 7 April 2015

Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1039/C4SC03949A
P932PMC publication ID5707456
P698PubMed publication ID29218153

P50authorDihua ShangguanQ42720719
Tao BingQ43367533
P2093author name stringNan Zhang
Linlin Wang
Cui Qi
Xiangjun Liu
Luyao Shen
P2860cites workHighly prevalent putative quadruplex sequence motifs in human DNAQ24529050
Prevalence of quadruplexes in the human genomeQ24529051
Nucleic acid aptamers: an emerging frontier in cancer therapyQ26849947
Discovery and development of anticancer aptamersQ28279248
2'-deoxyguanosine toxicity for B and mature T lymphoid cell lines is mediated by guanine ribonucleotide accumulationQ28366368
General cell-binding activity of intramolecular G-quadruplexes with parallel structureQ28487102
Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides.Q33286711
G-rich oligonucleotides alter cell cycle progression and induce apoptosis specifically in OE19 esophageal tumor cellsQ33322600
Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotidesQ33518274
Aptamers generated from cell-SELEX for molecular medicine: a chemical biology approachQ33598723
G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growthQ33730438
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA.Q33814333
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?Q34174883
RNA therapeutics: beyond RNA interference and antisense oligonucleotidesQ34248493
A new paradigm for aptamer therapeutic AS1411 action: uptake by macropinocytosis and its stimulation by a nucleolin-dependent mechanismQ34268342
How long is too long? Effects of loop size on G-quadruplex stabilityQ34368029
Inhibition of herpes simplex virus in culture by oligonucleotides composed entirely of deoxyguanosine and thymidineQ45785906
Specific DNA G-quadruplexes bind to ethanolaminesQ45854057
G-quadruplex DNA assemblies: loop length, cation identity, and multimer formationQ46483863
Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cellsQ48193623
Aptamers as therapeutics.Q51813594
DNAzyme hybridization, cleavage, degradation, and sensing in undiluted human blood serum.Q54285489
Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells.Q54499615
Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activityQ56552038
Intramolecular G-quartet motifs confer nuclease resistance to a potent anti-HIV oligonucleotideQ71058553
ERK1/2 inactivation and p38 MAPK-dependent caspase activation during guanosine 5'-triphosphate-mediated terminal erythroid differentiation of K562 cellsQ80418342
Role of G-quadruplex located at 5' end of mRNAsQ85334928
Selection of single-stranded DNA molecules that bind and inhibit human thrombinQ34616171
Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonistsQ34942985
Telomeric DNA induces apoptosis and senescence of human breast carcinoma cellsQ35749321
Generating aptamers by cell-SELEX for applications in molecular medicineQ35866033
A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinomaQ36028980
Telomere-homologous G-rich oligonucleotides sensitize human ovarian cancer cells to TRAIL-induced growth inhibition and apoptosisQ36862798
Enhanced cytotoxicity from deoxyguanosine-enriched T-oligo in prostate cancer cells.Q37139643
A targeted, self-delivered, and photocontrolled molecular beacon for mRNA detection in living cellsQ37218103
Selective Delivery of an Anticancer Drug with Aptamer-Functionalized Liposomes to Breast Cancer Cells in Vitro and in Vivo.Q37240103
Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancerQ37277677
Cellular uptake and intracellular trafficking of oligonucleotides: implications for oligonucleotide pharmacologyQ37656119
The application of DNA and RNA G-quadruplexes to therapeutic medicines.Q37905612
Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides.Q37944929
Therapeutic RNA aptamers in clinical trialsQ38059064
The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cellsQ38292167
AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolinQ38296831
Inhibition of DNA replication and induction of S phase cell cycle arrest by G-rich oligonucleotidesQ38297014
Cytotoxic G-rich oligodeoxynucleotides: putative protein targets and required sequence motifQ38300600
Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomasQ38309288
Aptamer imaging with Cu-64 labeled AS1411: preliminary assessment in lung cancerQ38310128
AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.Q38310861
Mechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonucleotides in VitroQ38312462
Interaction of G-rich GT oligonucleotides with nuclear-associated eEF1A is correlated with their antiproliferative effect in haematopoietic human cancer cell linesQ38313404
Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancerQ38315429
Antiproliferative activity of G-rich oligonucleotides correlates with protein bindingQ38320934
G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosisQ38336507
Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's diseaseQ38339107
Inhibition of human immunodeficiency virus type 1 activity in vitro by a new self-stabilized oligonucleotide with guanosine-thymidine quadruplex motifsQ39500769
Extracellular guanosine and GTP promote expression of differentiation markers and induce S-phase cell-cycle arrest in human SH-SY5Y neuroblastoma cells.Q39901080
Guanosine acts intracellularly to initiate apoptosis in NB4 cells: A role for nucleoside transportQ40084915
G-quadruplexes induce apoptosis in tumor cellsQ40192873
Nuclease resistance of telomere-like oligonucleotides monitored in live cells by fluorescence anisotropy imagingQ40311165
Poly-guanosine strings improve cellular uptake and stimulatory activity of phosphodiester CpG oligonucleotides in human leukocytesQ40494799
Mechanisms of 2'-deoxyguanosine toxicity in mouse T-lymphoma cells with purine nucleoside phosphorylase deficiency and resistance to inhibition of ribonucleotide reductase by dGTP.Q41194286
Guanine nucleosides and Jurkat cell death: roles of ATP depletion and accumulation of deoxyribonucleotidesQ43792064
P433issue7
P921main subjectcytotoxicityQ246181
P304page(s)3831-3838
P577publication date2015-04-07
P1433published inChemical ScienceQ2962267
P1476titleCytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides
P478volume6

Reverse relations

cites work (P2860)
Q58577197An Intrinsic Mitochondrial Pathway Is Required for Phytic Acid-Chitosan-Iron Oxide Nanocomposite (Phy-CS-MNP) to Induce G₀/G₁ Cell Cycle Arrest and Apoptosis in the Human Colorectal Cancer (HT-29) Cell Line
Q90614045Bimodular Antiparallel G-Quadruplex Nanoconstruct with Antiproliferative Activity
Q38294771Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding
Q33878197G-quadruplex structure of an anti-proliferative DNA sequence
Q38698547Monomolecular G-quadruplex structures with inversion of polarity sites: new topologies and potentiality
Q55713100Oxidative degradation of polyamines by serum supplement causes cytotoxicity on cultured cells.
Q55426472ROS-Mediated Mitochondrial Pathway is Required for Manilkara Zapota (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-κB Activities of HeLa Human Cervical Cancer Cells.
Q36299184Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative

Search more.