Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators

scientific article published on 20 May 2004

Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M403413200
P698PubMed publication ID15155739

P50authorDiomedes E LogothetisQ86536024
P2093author name stringHailin Zhang
Tooraj Mirshahi
Tibor Rohacs
Xiaona Du
Coeli Lopes
P2860cites workAlterations in conserved Kir channel-PIP2 interactions underlie channelopathiesQ24300436
Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolutionQ27640256
Suppression of Kir2.3 activity by protein kinase C phosphorylation of the channel protein at threonine 53Q28141759
Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brainQ28205930
Electrophysiology of the pancreatic beta-cellQ28240546
Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cellsQ28259615
Regulation of a G protein-gated inwardly rectifying K+ channel by a Ca(2+)-independent protein kinase CQ28344010
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCsQ28511979
Depletion of phosphatidylinositol 4,5-bisphosphate by activation of phospholipase C-coupled receptors causes slow inhibition but not desensitization of G protein-gated inward rectifier K+ current in atrial myocytes.Q31650674
Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels.Q31924379
Adaptor proteins in protein kinase C-mediated signal transductionQ34095764
Intracellular regulation of inward rectifier K+ channelsQ34155117
Membrane phospholipid control of nucleotide sensitivity of KATP channelsQ34478704
Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphatesQ35806004
Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channelsQ36436285
Biophysical and molecular mechanisms underlying the modulation of heteromeric Kir4.1-Kir5.1 channels by CO2 and pH.Q36436721
Phospholipase C-linked receptors regulate the ATP-sensitive potassium channel by means of phosphatidylinositol 4,5-bisphosphate metabolismQ36786756
pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndromeQ36787083
Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B.Q40731586
Renal K+ channels: structure and functionQ41387953
Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytesQ41846011
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectificationQ42282616
Inhibition of a Gi-activated potassium channel (GIRK1/4) by the Gq-coupled m1 muscarinic acetylcholine receptorQ42495425
PIP2 and PIP as determinants for ATP inhibition of KATP channelsQ42538515
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by GbetagammaQ42544747
Direct activation of cloned K(atp) channels by intracellular acidosisQ43559592
Regulation of IRK3 Inward RectifierK + Channel by m1 Acetylcholine Receptorand Intracellular MagnesiumQ44040479
Differential sensitivity of inward rectifier K+ channels to metabolic inhibitorsQ44064105
Alpha1-adrenoceptor-mediated breakdown of phosphatidylinositol 4,5-bisphosphate inhibits pinacidil-activated ATP-sensitive K+ currents in rat ventricular myocytesQ44095805
Human cardiac inwardly-rectifying K+ channel Kir(2.1b) is inhibited by direct protein kinase C-dependent regulation in human isolated cardiomyocytes and in an expression systemQ44138536
Phosphatidylinositol 4,5-bisphosphate (PIP2) modulation of ATP and pH sensitivity in Kir channels. A tale of an active and a silent PIP2 site in the N terminusQ44270128
Protein kinase C inhibits ROMK1 channel activity via a phosphatidylinositol 4,5-bisphosphate-dependent mechanismQ44342700
Mechanosensitivity of GIRK channels is mediated by protein kinase C-dependent channel-phosphatidylinositol 4,5-bisphosphate interaction.Q44683530
Effects of anoxia on K and Ca currents in isolated guinea pig cardiocytesQ45220490
Cardiac potassium channels in health and diseaseQ47772758
Molecular mechanism for sodium-dependent activation of G protein-gated K+ channelsQ48564702
Neurotensin inhibition of the hyperpolarization-activated cation current (Ih) in the rat substantia nigra pars compacta implicates the protein kinase C pathwayQ48636898
Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitizationQ48886242
Gating of inward rectifier K+ channels by proton-mediated interactions of N- and C-terminal domainsQ48886814
Phosphatidylinositol 4,5-bisphosphate and intracellular pH regulate the ROMK1 potassium channel via separate but interrelated mechanismsQ48893530
Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactionsQ48906142
Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutantsQ48946365
Specific regions of heteromeric subunits involved in enhancement of G protein-gated K+ channel activityQ48960840
Protein kinase C inhibition of cloned inward rectifier (HRK1/KIR2.3) K+ channels expressed in Xenopus oocytesQ48985767
P433issue36
P407language of work or nameEnglishQ1860
P1104number of pages11
P304page(s)37271-37281
P577publication date2004-05-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleCharacteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators
P478volume279