Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia.

scientific article published on 19 January 2018

Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0191070
P8608Fatcat IDrelease_xnsddmooobbjborse5uqaufpzm
P932PMC publication ID5774758
P698PubMed publication ID29351316

P50authorChung-Hsi HsingQ89916757
P2093author name stringLiang-Po Hsieh
Tsui-Shan Wei
Ming-Chung Lin
Chia-Cheng Chang
Ching-Hua Yeh
Hui-Ching Lin
P2860cites workThe role of Nox2-derived ROS in the development of cognitive impairment after sepsisQ21245247
Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe SepsisQ24628579
From inflammation to sickness and depression: when the immune system subjugates the brainQ24633527
Twenty years of research on cytokine-induced sickness behaviorQ24684760
Caspases playing in the field of neuroinflammation: old and new playersQ26829165
Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation.Q48736659
Cholecystokinin receptors do not mediate the suppression of food-motivated behavior by lipopolysaccharide and interleukin-1 beta in mice.Q52890982
Caspase signalling controls microglia activation and neurotoxicity.Q53422658
The effects of noradrenaline and alpha-2 adrenoceptor agents on the production of monocytic productsQ56767334
Neuronal regulation of interleukin 6 secretion in murine spleen: adrenergic and opioidergic controlQ58043511
Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of miceQ60777374
Dexmedetomidine attenuates lipopolysaccharide-induced proinflammatory response in primary microgliaQ84342851
Microglia-specific localisation of a novel calcium binding protein, Iba1Q28273977
Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microgliaQ28508347
α2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5Q28566337
Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune systemQ33303316
Cytokine-induced sickness behavior.Q33964676
Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microgliaQ33982445
Catalytic antioxidants and neurodegenerationQ34104938
Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice.Q34655648
Intracellular signaling in M-CSF-induced microglia activation: role of Iba1.Q34963694
Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicityQ35162073
Microglia activation in sepsis: a case-control studyQ35612988
Acute renal failure and sepsisQ35833149
The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative diseaseQ35841846
Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior.Q35995176
Endotoxin- or pro-inflammatory cytokine-induced sickness behavior as an animal model of depression: focus on anhedonia.Q36119083
Dexmedetomidine: a novel sedative-analgesic agentQ36348758
Perioperative use of alpha2-adrenoceptor agonists and the cardiac patientQ36409164
Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120Q36642906
Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member PumaQ36733199
Microglia biology in health and disease.Q37015357
Systemic immune activation leads to neuroinflammation and sickness behavior in miceQ37044561
Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative diseaseQ37078772
Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharideQ37109623
Dexmedetomidine: a review of clinical applicationsQ37228095
Microglial cell origin and phenotypes in health and diseaseQ37949246
Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophagesQ39889385
Cytotoxicity of microgliaQ40870381
A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineageQ41183035
Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system.Q41993255
Dexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expression in the rat hippocampusQ43625457
Dexmedetomidine controls systemic cytokine levels through the cholinergic anti-inflammatory pathwayQ43944679
Evaluation of the face validity of reserpine administration as an animal model of depression--Parkinson's disease association.Q44171265
Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in ratsQ44929459
Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtypeQ45089164
Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system.Q45138189
Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal ratsQ46057946
Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat.Q46095069
Dexmedetomidine increases hippocampal phosphorylated extracellular signal-regulated protein kinase 1 and 2 content by an alpha 2-adrenoceptor-independent mechanism: evidence for the involvement of imidazoline I1 receptorsQ46739677
Does dexmedetomidine prevent emergence delirium in children after sevoflurane-based general anesthesia?Q46832602
Role of IL-1 in poststroke depressive-like behavior in miceQ48520668
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdexmedetomidineQ412133
lipopolysaccharideQ421804
anhedoniaQ545365
neuronitisQ17157137
P304page(s)e0191070
P577publication date2018-01-19
P1433published inPLOS OneQ564954
P1476titleDexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia
P478volume13

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cites work (P2860)
Q93140574Dexmedetomidine protects aged rats from postoperative cognitive dysfunction by alleviating hippocampal inflammation
Q55093171Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.
Q61801820The effects of novel α-adrenoreceptor agonist dexmedetomidine on shivering in patients underwent caesarean section

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