The impact of farnesol in combination with fluconazole on Candida albicans biofilm: regulation of ERG20, ERG9, and ERG11 genes

scientific article published on 12 December 2017

The impact of farnesol in combination with fluconazole on Candida albicans biofilm: regulation of ERG20, ERG9, and ERG11 genes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12223-017-0574-Z
P8608Fatcat IDrelease_6lk7fhevfbbwplmim3qt3u425i
P698PubMed publication ID29234974

P2093author name stringHelena Bujdáková
Lucia Černáková
Stanislava Dižová
P2860cites workAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extensionQ27348786
Upregulation of ERG genes in Candida species by azoles and other sterol biosynthesis inhibitorsQ28344744
Farnesol-induced apoptosis in Candida albicansQ30487814
The expression of genes involved in the ergosterol biosynthesis pathway in Candida albicans and Candida dubliniensis biofilms exposed to fluconazoleQ33351744
Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agentsQ33689421
Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serumQ33913164
Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilmsQ33982871
Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilmQ34079974
Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathioneQ34113632
Enhanced production of farnesol by Candida albicans treated with four azolesQ34142059
In vitro interactions between farnesol and fluconazole, amphotericin B or micafungin against Candida albicans biofilmsQ35152853
Role for cell density in antifungal drug resistance in Candida albicans biofilmsQ35878982
Biofilm formation is a risk factor for mortality in patients with Candida albicans bloodstream infection-Scotland, 2012-2013.Q36486984
Candida albicans biofilms: development, regulation, and molecular mechanismsQ36880010
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The quorum-sensing molecule farnesol is a modulator of drug efflux mediated by ABC multidrug transporters and synergizes with drugs in Candida albicansQ38626885
Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol.Q39491534
Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing moleculeQ39661623
Biochemical targets for antifungal azole derivatives: hypothesis on the mode of action.Q39844899
Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathwayQ40327252
Physiological implications of sterol biosynthesis in yeastQ40945250
Effectiveness of the Photoactive Dye Methylene Blue versus Caspofungin on the Candida parapsilosis Biofilm in vitro and ex vivoQ41653179
Purification and properties of cytochrome P-450-dependent 14 alpha-sterol demethylase from Candida albicansQ41948927
Cell density and cell aging as factors modulating antifungal resistance of Candida albicans biofilms.Q42111899
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Blocking of Candida albicans biofilm formation by cis-2-dodecenoic acid and trans-2-dodecenoic acidQ42730259
Contribution of clinically derived mutations in ERG11 to azole resistance in Candida albicansQ43102358
Secretion of E,E-farnesol and biofilm formation in eight different Candida speciesQ43156685
In vitro activity of gatifloxacin alone and in combination with cefepime, meropenem, piperacillin and gentamicin against multidrug-resistant organismsQ44405025
Pravastatin inhibits farnesol production in Candida albicans and improves survival in a mouse model of systemic candidiasisQ46573245
Changes in glutathione-dependent redox status and mitochondrial energetic strategies are part of the adaptive response during the filamentation process in Candida albicansQ46867132
Effect of squalene synthase gene disruption on synthesis of polyprenols in Saccharomyces cerevisiae.Q52531897
Anti-Candida activity of four antifungal benzothiazoles.Q54231014
Correlation between the sterol composition of membranes and morphology in Candida albicansQ68143494
Regulation of squalene synthetase and squalene epoxidase activities in Saccharomyces cerevisiaeQ69566477
Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutationsQ70409691
The role of ERG20 gene (encoding yeast farnesyl diphosphate synthase) mutation in long dolichol formation. Molecular modeling of FPP synthaseQ73039101
Synergy, antagonism, and what the chequerboard puts between themQ73521098
Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiaeQ77784495
P921main subjectCandida albicansQ310443
fluconazoleQ411478
biofilmQ467410
P577publication date2017-12-12
P1433published inFolia MicrobiologicaQ15762225
P1476titleThe impact of farnesol in combination with fluconazole on Candida albicans biofilm: regulation of ERG20, ERG9, and ERG11 genes