Controlled Hypercapnia Enhances Cerebral Blood Flow and Brain Tissue Oxygenation After Aneurysmal Subarachnoid Hemorrhage: Results of a Phase 1 Study

scientific article published on 17 February 2016

Controlled Hypercapnia Enhances Cerebral Blood Flow and Brain Tissue Oxygenation After Aneurysmal Subarachnoid Hemorrhage: Results of a Phase 1 Study is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12028-016-0246-X
P698PubMed publication ID26886010

P50authorNorbert RoewerQ87347974
P2093author name stringChristopher Lotz
Christian Stetter
Ralf-Ingo Ernestus
Thomas Westermaier
Nadine Willner
Christian Kilgenstein
Ekkehard Kunze
Judith Holzmeier
Judith Weiland
Ralf Michael Muellenbach
Stefan Koehler
P2860cites workInterobserver agreement in assessing early CT signs of middle cerebral artery infarctionQ48905970
Respiration and cerebral blood flow in metabolic acidosis and alkalosis in humansQ49012862
Thresholds of focal cerebral ischemia in awake monkeysQ51867373
Predictors of cerebral infarction in aneurysmal subarachnoid hemorrhage.Q53619781
Noninvasive measurement of cerebral vasopasm in patients with subarachnoid hemorrhageQ66973797
CBF adaption in man to chronic hypo- and hypercapnia and its relation to CSF pHQ68550194
CO2 reactivity of cerebral vasospasm after aneurysmal subarachnoid haemorrhageQ69210455
Cerebral blood flow during and after hyperventilationQ71573811
Adaptation of CBF during induced chronic normooxic respiratory acidosisQ72182009
Reduced cerebral blood flow but intact reactivity to hypercarbia and hypoxia following subarachnoid hemorrhage in rabbitsQ72661958
Effect of carbon dioxide on pulmonary vascular tone at various pulmonary arterial pressure levels induced by endothelin-1Q83164496
Permissive range of hypercapnia for improved peripheral microcirculation and cardiac output in rabbitsQ33298874
Effects of clinically relevant acute hypercapnic and metabolic acidosis on the cardiovascular system: an experimental porcine studyQ33752623
Burden of disease and costs of aneurysmal subarachnoid haemorrhage (aSAH) in the United KingdomQ33868965
Hypocapnia and the injured brain: more harm than benefit.Q37709104
Delayed neurological deterioration after subarachnoid haemorrhageQ38169976
Fast and slow components of cerebral blood flow response to step decreases in end-tidal PCO2 in humans.Q39446031
Defining vasospasm after subarachnoid hemorrhage: what is the most clinically relevant definition?Q39880670
Value of transcranial Doppler, perfusion-CT and neurological evaluation to forecast secondary ischemia after aneurysmal SAH.Q40133547
Permissive hypercapnia in ARDS and its effect on tissue oxygenationQ40968974
CO2 reactivity in patients after subarachnoid haemorrhageQ41688745
Global cerebral edema after subarachnoid hemorrhage: frequency, predictors, and impact on outcomeQ43629455
Altered cerebral autoregulation and CO2 reactivity after aneurysmal subarachnoid hemorrhageQ45108265
Mortality rates after subarachnoid hemorrhage: variations according to hospital case volume in 18 statesQ47393999
Effects of morphine on cerebral blood flow autoregulation CO2-reactivity in experimental subarachnoid hemorrhage.Q48087391
The effect of lung-protective permissive hypercapnia in intracerebral pressure in patients with subarachnoid haemorrhage and ARDS. A retrospective studyQ48093463
Central and regional blood flow during hyperventilation. An experimental study in the pig.Q48180950
Cerebrovascular carbon dioxide reactivity and delayed cerebral ischemia after subarachnoid hemorrhageQ48239041
Altered cerebrovascular CO2 reactivity following subarachnoid hemorrhage in catsQ48271374
Spontaneous hyperventilation and brain tissue hypoxia in patients with severe brain injuryQ48386518
Controlled transient hypercapnia: a novel approach for the treatment of delayed cerebral ischemia after subarachnoid hemorrhage?Q48590620
P433issue2
P921main subjecthypercapniaQ615759
cerebral blood flowQ5064096
brain tissueQ11850260
aneurysmal subarachnoid hemorrhageQ108323719
P304page(s)205-214
P577publication date2016-02-17
P1433published inNeurocritical CareQ15745303
P1476titleControlled Hypercapnia Enhances Cerebral Blood Flow and Brain Tissue Oxygenation After Aneurysmal Subarachnoid Hemorrhage: Results of a Phase 1 Study
P478volume25

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cites work (P2860)
Q60044464Association of abnormal carbon dioxide levels with poor neurological outcomes in aneurysmal subarachnoid hemorrhage: a retrospective observational study
Q92777587High-normal PaCO2 values might be associated with worse outcome in patients with subarachnoid hemorrhage - a retrospective cohort study
Q92846052Hyperventilation in neurological patients: from physiology to outcome evidence
Q54247299Nitric Oxide, Controlled Hypercapnia, and Cerebral Vasospasm: New Therapeutic Insights.
Q92892223Protocolized Brain Oxygen Optimization in Subarachnoid Hemorrhage
Q48238677What Do We Mean by Poor-Grade Aneurysmal Subarachnoid Hemorrhage and What Can We Do?
Q88177994[Extracorporeal lung support]

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