Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells

scientific article

Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.DEVCEL.2017.09.012
P932PMC publication ID5663201
P698PubMed publication ID29033361

P50authorGuangwei DuQ87175990
P2093author name stringPing Wu
Feng Zhang
Junmin Peng
Li Qin
Gilbert Di Paolo
Jianming Xu
Jeffrey T Chang
Ming Cai
Ziqing Wang
Weiqi Nian
Yuanyuan Weng
Li Wei Rachel Tay
Jingquan He
Laura B McIntire
P2860cites workTLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cellsQ24298072
Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosisQ24304439
Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodiaQ24313584
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and functionQ24614572
Comprehensive molecular portraits of human breast tumoursQ24630844
PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology ConsortiumQ24644341
RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free systemQ24645824
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasionQ27309213
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
The phospholipase D superfamily as therapeutic targetsQ28082479
PIP kinases define PI4,5P₂signaling specificity by association with effectorsQ28083975
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formationQ28139699
Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cellsQ37603284
Traffic control: regulation of kinesin motors.Q37620153
Phospholipase D (PLD) drives cell invasion, tumor growth and metastasis in a human breast cancer xenograph modelQ37665324
Invading one step at a time: the role of invadopodia in tumor metastasisQ37672635
Myosin VI rewrites the rules for myosin motorsQ37755563
Regulation and functions of diacylglycerol kinasesQ37908068
Is there new hope for therapeutic matrix metalloproteinase inhibition?Q38265674
Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell InvasionQ38921801
Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2.Q39014592
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumorsQ39542520
Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and functionQ40304153
Systematical optimization of reverse-phase chromatography for shotgun proteomicsQ42068281
Measuring plasma membrane protein endocytic rates by reversible biotinylationQ42859043
KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding, and extracellular matrix degradation in primary macrophagesQ44425994
Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surfaceQ44547427
Analysis of Phosphatidic Acid Binding and Regulation of PIPKI In Vitro and in Intact Cells.Q51210287
Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase familyQ28267069
A perspective on cancer cell metastasisQ28307891
Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic diseaseQ28570541
Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulumQ29547483
Kinesin superfamily motor proteins and intracellular transportQ29615770
Circulating tumor cells, disease progression, and survival in metastatic breast cancerQ29619276
Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival.Q30252850
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficitsQ30497694
N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopodsQ30527787
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasivenessQ33399066
Leveraging the membrane - cytoskeleton interface with myosin-1.Q33965456
Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.Q34044522
Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancerQ34268347
An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recyclingQ34298393
The carboxyl-terminal domain of kinesin heavy chain is important for membrane bindingQ34348261
The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivoQ34469526
JUMP: a tag-based database search tool for peptide identification with high sensitivity and accuracyQ34635037
Twist1-induced invadopodia formation promotes tumor metastasis.Q34770401
Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D.Q35770538
Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cellsQ35894349
Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide poolsQ36255578
Phosphatidic acid regulation of PIPKI is critical for actin cytoskeletal reorganizationQ36387173
Phosphatidic acid- and phosphatidylserine-binding proteinsQ36453653
Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolismQ36869216
The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expressionQ36898979
Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's diseaseQ37013968
Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasisQ37041152
Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formationQ37068408
Endocytic transport of integrins during cell migration and invasion.Q37154499
U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's diseaseQ37236333
Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatasesQ37336964
Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors).Q37432821
Analysis of Invadopodia Formation in Breast Cancer CellsQ37495189
Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cellsQ37546020
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectlung metastasisQ1877473
P304page(s)186-197.e7
P577publication date2017-10-11
P1433published inDevelopmental CellQ1524277
P1476titleBinding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells
P478volume43

Reverse relations

cites work (P2860)
Q92782388A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis
Q97537900Altered mitochondrial trafficking as a novel mechanism of cancer metastasis
Q98771694DDHD1, but Not DDHD2, Suppresses Neurite Outgrowth in SH-SY5Y and PC12 Cells by Regulating Protein Transport From Recycling Endosomes
Q91741772Effect of simulated microgravity on metabolism of HGC-27 gastric cancer cells
Q91063128From physics to physiology at the membrane-motor interface
Q58108133Functional analysis of mammalian phospholipase D enzymes
Q90661971Insulin activates intracellular transport of lipid droplets to release triglycerides from the liver
Q52586342Lipin-1 determines lung cancer cell survival and chemotherapy sensitivity by regulation of endoplasmic reticulum homeostasis and autophagy.
Q93342758MT1-MMP Binds Membranes by Opposite Tips of Its β Propeller to Position It for Pericellular Proteolysis
Q91832231MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms
Q50077060PLD and PA Take MT1-MMP for a Metastatic Ride.
Q64065338PLD-dependent phosphatidic acid microdomains are signaling platforms for podosome formation
Q91962766Phosphatidic acid generated by PLD2 promotes the plasma membrane recruitment of IQGAP1 and neointima formation
Q47386895Proliferative and metastatic roles for Phospholipase D in mouse models of cancer.
Q89578545Regulation of MT1-MMP Activity through Its Association with ERMs
Q64886187Regulation of Membrane Turnover by Phosphatidic Acid: Cellular Functions and Disease Implications.
Q90584259Vesicle trafficking pathways that direct cell migration in 3D matrices and in vivo

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