Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging.

scientific article

Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging. is …
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scholarly articleQ13442814

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P356DOI10.1093/HUMUPD/DMX026
P698PubMed publication ID28961822

P50authorAntonio CapalboQ48562324
Eva R HoffmannQ57869204
P2093author name stringFilippo Maria Ubaldi
Laura Rienzi
Danilo Cimadomo
P2860cites workAge-related decrease of meiotic cohesins in human oocytesQ21559470
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated agingQ22337238
Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cellsQ24303869
Sororin mediates sister chromatid cohesion by antagonizing WaplQ24309280
Extreme heterogeneity in the molecular events leading to the establishment of chiasmata during meiosis i in human oocytesQ24530701
Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombinationQ45875368
Polar body analysis by array comparative genomic hybridization accurately predicts aneuploidies of maternal meiotic origin in cleavage stage embryos of women of advanced maternal age.Q46103965
Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2Q46305683
Maternal meiosis II nondisjunction in trisomy 21 is associated with maternal low socioeconomic statusQ46541129
Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes.Q46831372
Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection studyQ46879263
Inefficient Crossover Maturation Underlies Elevated Aneuploidy in Human Female Meiosis.Q47839266
Inherent Instability of Correct Kinetochore-Microtubule Attachments during Meiosis I in OocytesQ48577336
Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitorsQ48585586
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Telomere lengths in human pronuclei, oocytes and spermatozoaQ48628095
High-fat diet causes lipotoxicity responses in cumulus-oocyte complexes and decreased fertilization rates.Q48690736
Prospective cohort study in high responder oocyte donors using two hormonal stimulation protocols: impact on embryo aneuploidy and developmentQ48694914
Comparative genomic hybridization of oocytes and first polar bodies from young donorsQ48714397
Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint.Q48725350
Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in miceQ48787887
First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidyQ48852165
Mechanisms of non-disjunction in human female meiosis: the co-existence of two modes of malsegregation evidenced by the karyotyping of 1397 in-vitro unfertilized oocytesQ48854145
Chromosomal abnormalities in the first and second polar body.Q48877812
Spontaneous X chromosome MI and MII nondisjunction events in Drosophila melanogaster oocytes have different recombinational historiesQ48971515
Influence of maternal age on meiotic spindle assembly in oocytes from naturally cycling womenQ48983154
Meiosis I in human oocytesQ49074034
Near-human aneuploidy levels in female mice with homeologous chromosomes.Q50646373
SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction.Q50656030
Telomere length in human blastocysts.Q50683956
Chiasma frequency and maternal age in mammals.Q53022388
Absence of SYCP3 mutations in women with recurrent miscarriage with at least one trisomic miscarriage.Q53196587
High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans.Q53501423
Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation.Q54196841
A Presumptive Human XXY/XX MosaicQ59088561
The DNA-damage response in human biology and diseaseQ24606586
Human aneuploidy: mechanisms and new insights into an age-old problemQ24631178
DNA damage responses in mammalian oocytesQ26749217
Meiosis-specific cohesin component, Stag3 is essential for maintaining centromere chromatid cohesion, and required for DNA repair and synapsis between homologous chromosomesQ27315101
Live imaging RNAi screen reveals genes essential for meiosis in mammalian oocytesQ27316412
Mutations in TUBB8 and Human Oocyte Meiotic ArrestQ28117002
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1Q28215916
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repairQ28267893
Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencingQ28281877
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing overQ28282791
Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathwayQ28306981
Mps1 at kinetochores is essential for female mouse meiosis IQ28504960
The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertilityQ28505195
Meiotic pachytene arrest in MLH1-deficient miceQ28510650
Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination ratesQ28603618
Centromere-proximal crossovers are associated with precocious separation of sister chromatids during meiosis in Saccharomyces cerevisiaeQ28764746
Mutant Cohesin in Premature Ovarian FailureQ29399144
To err (meiotically) is human: the genesis of human aneuploidyQ29618613
The synaptonemal complex protein SCP3 can form multistranded, cross-striated fibers in vivoQ30431091
Bivalent separation into univalents precedes age-related meiosis I errors in oocytes.Q30658203
Loss of Centromere Cohesion in Aneuploid Human Oocytes Correlates with Decreased Kinetochore Localization of the Sac Proteins Bub1 and Bubr1Q30841621
Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I.Q33307520
Meiotic recombination in human oocytes.Q33504551
Cytogenetic analyses of human oocytes provide new data on non-disjunction mechanisms and the origin of trisomy 16.Q33510523
Endoplasmic reticulum (ER) stress in cumulus-oocyte complexes impairs pentraxin-3 secretion, mitochondrial membrane potential (DeltaPsi m), and embryo developmentQ33636667
Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindlesQ33757640
An algorithm for determining the origin of trisomy and the positions of chiasmata from SNP genotype dataQ33790894
Examining variation in recombination levels in the human female: a test of the production-line hypothesisQ33858796
Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryosQ33920653
Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice.Q33953122
Telomere DNA deficiency is associated with development of human embryonic aneuploidyQ33954500
The association of low socioeconomic status and the risk of having a child with Down syndrome: a report from the National Down Syndrome ProjectQ34007112
Translating dosage compensation to trisomy 21Q34037496
Telomere lengths in human oocytes, cleavage stage embryos and blastocystsQ34093527
Cohesin in gametogenesisQ38071431
The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screeningQ38172667
The meiosis-specific modification of mammalian telomeres.Q38215586
Self-organization of meiotic recombination initiation: general principles and molecular pathwaysQ38271059
Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosisQ38344945
Gene expression profiles of single human mature oocytes in relation to age.Q38346535
Therapeutic opportunities within the DNA damage responseQ38364665
Oocyte maturation: gamete-somatic cells interactions, meiotic resumption, cytoskeletal dynamics and cytoplasmic reorganization.Q38368170
Meiotic Silencing in MammalsQ38657326
In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled studyQ38825105
Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidyQ38860108
SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytesQ38902484
Prenatal and pre-implantation genetic diagnosisQ38954748
A New Mode of Mitotic SurveillanceQ39130830
Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic MaturationQ39209262
Endoplasmic reticulum proteostasis impairment in agingQ39258127
Sequential comprehensive chromosome analysis on polar bodies, blastomeres and trophoblast: insights into female meiotic errors and chromosomal segregation in the preimplantation window of embryo development.Q39520963
Down syndrome, paternal age, maternal age and birth orderQ39846300
Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trialQ40254344
Chromosome micromanipulation. 3. Spindle fiber tension and the reorientation of mal-oriented chromosomesQ41117163
Chiasmata, meiotic univalents, and age in relation to aneuploid imbalance in miceQ43514845
Metaphase I arrest upon activation of the Mad2-dependent spindle checkpoint in mouse oocytesQ44587845
Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytesQ45046784
Defective deacetylation of histone 4 K12 in human oocytes is associated with advanced maternal age and chromosome misalignmentQ45354821
Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes.Q34126610
Polar body based aneuploidy screening is poorly predictive of embryo ploidy and reproductive potentialQ34145730
Chromosomal mosaicism in human preimplantation embryos: a systematic reviewQ34181395
A case of human intersexuality having a possible XXY sex-determining mechanismQ34245719
Recombination rate and reproductive success in humansQ34356290
Chromosomal abnormalities in oocytesQ34384550
Escape from crossover interference increases with maternal age.Q34463616
Maternal transmission ratio distortion at the mouse Om locus results from meiotic drive at the second meiotic divisionQ34573347
Altered cohesin gene dosage affects Mammalian meiotic chromosome structure and behavior.Q34585707
Aneuploidy across individual chromosomes at the embryonic level in trophectoderm biopsies: changes with patient age and chromosome structureQ35321057
Oocyte-specific differences in cell-cycle control create an innate susceptibility to meiotic errorsQ35576326
Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrestQ35631586
Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsiesQ35722205
Human oocytes. Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes.Q35768588
Can Comprehensive Chromosome Screening Technology Improve IVF/ICSI Outcomes? A Meta-AnalysisQ35808903
Age-related aneuploidy through cohesion exhaustionQ36008286
Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisationQ36035686
Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cellsQ36131205
Correction of Down syndrome and Edwards syndrome aneuploidies in human cell culturesQ36131210
Effect of maternal age on the frequency of cytogenetic abnormalities in human oocytesQ36271536
Effect of meiotic recombination on the production of aneuploid gametes in humansQ36271551
Moderate ovarian stimulation does not increase the incidence of human embryo chromosomal abnormalities in in vitro fertilization cyclesQ36293552
DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpointQ36319891
DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age.Q36341410
Consistent and reproducible outcomes of blastocyst biopsy and aneuploidy screening across different biopsy practitioners: a multicentre study involving 2586 embryo biopsiesQ36368721
Chromosome cohesion decreases in human eggs with advanced maternal age.Q36377255
Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human spermQ36475986
Embryos whose polar bodies contain isolated reciprocal chromosome aneuploidy are almost always euploidQ36534703
The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genesQ36645944
Human female meiosis: what makes a good egg go bad?Q37055902
Whole genome amplification from a single cell: implications for genetic analysisQ37081188
Mutations of the SYCP3 gene in women with recurrent pregnancy lossQ37156173
Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic DisordersQ37185705
Patterns of meiotic recombination in human fetal oocytesQ37217307
P433issue6
P921main subjectgenomicsQ222046
P304page(s)706-722
P577publication date2017-11-01
P1433published inHuman Reproduction UpdateQ15724523
P1476titleHuman female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging
P478volume23

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cites work (P2860)
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