Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes

scientific article published in January 1996

Natural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/BF01718157
P698PubMed publication ID8678828

P2093author name stringN Hunter
M J Stear
W Goldmann
J Hope
J D Foster
C Bostock
P2860cites workSwaledale sheep affected by natural scrapie differ significantly in PrP genotype frequencies from healthy sheep and those selected for reduced incidence of scrapieQ30053018
Two alleles of a neural protein gene linked to scrapie in sheepQ33495492
Genetic aspects of unconventional virus infections: the basis of the virino hypothesisQ34163744
Sheep major histocompatibility (OLA) complex: linkage between a scrapie susceptibility/resistance locus and the OLA complex in Ile-de-France sheep progeniesQ41432924
Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapieQ42693681
A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infectionQ42798292
Linkage of the gene for the scrapie-associated fibril protein (PrP) to the Sip gene in Cheviot sheepQ43572895
PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapieQ43969509
The association of a codon 136 PrP gene variant with the occurrence of natural scrapieQ44135349
Genetic predisposition to iatrogenic Creutzfeldt-Jakob diseaseQ44697981
Partial dominance of the sA allele of the Sip gene for controlling experimental scrapieQ44884850
Transmission of bovine spongiform encephalopathy to sheep, goats, and miceQ47561938
PrP genotypes and the Sip gene in Cheviot sheep form the basis for scrapie strain typing in sheepQ47561943
Transmission of bovine spongiform encephalopathy to sheep and goatsQ47565069
Studies on maternal transmission of scrapie in sheep by embryo transferQ47570153
Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip geneQ47572251
Restriction fragment length polymorphisms of the scrapie-associated fibril protein (PrP) gene and their association with susceptibility to natural scrapie in British sheepQ47573187
Observations on the transmission of scrapie in experiments using embryo transferQ47631555
Some factors controlling the incidence of scrapie in Cheviot sheep injected with a Cheviot-passaged scrapie agentQ47696090
Genetic analysis of the antigens defined at the third international BoLA workshop.Q53405563
PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis.Q54254632
An ovine lymphocyte antigen is associated with reduced faecal egg counts in four-month-old lambs following natural, predominantly Ostertagia circumcincta infectionQ60689272
Different allelic effects of the codons 136 and 171 of the prion protein gene in sheep with natural scrapieQ60895162
Diverse biological parameters in clinically healthy sheep from a flock with scrapie: variations, and correlations with OLA antigensQ67996521
Letter: ScrapieQ68349505
Genetic control of scrapie in Cheviot and Suffolk sheepQ68515167
The unusual properties of CH1641, a sheep-passaged isolate of scrapieQ70407076
Amino acid polymorphisms of PrP with reference to onset of scrapie in Suffolk and Corriedale sheep in JapanQ71832114
Similar genetic susceptibility in iatrogenic and sporadic Creutzfeldt-Jakob diseaseQ72256087
Identification of five allelic variants of the sheep PrP gene and their association with natural scrapieQ72646867
Scrapie: A transmissible and hereditary disease of sheepQ79047277
P433issue5
P304page(s)809-824
P577publication date1996-01-01
P1433published inArchives of VirologyQ2860564
P1476titleNatural scrapie in a closed flock of Cheviot sheep occurs only in specific PrP genotypes
P478volume141

Reverse relations

cites work (P2860)
Q36112292A Targeted Survey for Scrapie in Jos Plateau State, Nigeria
Q39602836A centuries-long epidemic of scrapie in British sheep?
Q36571037A critical analysis of disease-associated DNA polymorphisms in the genes of cattle, goat, sheep, and pig.
Q56830958A genetic interpretation of heightened risk of BSE in offspring of affected dams
Q52230973A mathematical model of the dynamics of scrapie in a sheep flock.
Q47906164A new allelic variant in the bovine prion protein gene (PRNP) coding region
Q39440292Allelic frequency and genotypes of prion protein at codon 136 and 171 in Iranian Ghezel sheep breeds
Q36177322An overview of transmissible spongiform encephalopathies
Q34482525Analysis of the sheep genome
Q33617991Archival search for historical atypical scrapie in sheep reveals evidence for mixed infections
Q78541953Assessing the efficacy of a ram-genotyping programme to reduce susceptibility to scrapie in Great Britain
Q80050036Assessment of clinical criteria to diagnose scrapie in Italy
Q46966389Assessment of inbreeding resulting from selection for scrapie resistance: a model for rare sheep breeds
Q33828597Atypical/Nor98 scrapie infectivity in sheep peripheral tissues
Q43753771Autonomic nervous system innervation of lymphoid territories in spleen: a possible involvement of noradrenergic neurons for prion neuroinvasion in natural scrapie
Q33700440Big decisions based on small numbers: lessons from BSE.
Q89185669Biodiversity and selection for scrapie resistance in sheep: genetic polymorphism in eight breeds of Algeria
Q34569599Breeding with resistant rams leads to rapid control of classical scrapie in affected sheep flocks
Q43737694CNA42 monoclonal antibody identifies FDC as PrPsc accumulating cells in the spleen of scrapie affected sheep
Q54359966Characterization of the PRNP gene locus in Chios dairy sheep and its association with milk production and reproduction traits.
Q42649262Comparative analysis of the prion protein open reading frame nucleotide sequences in peacock and parakeet
Q25255274Comparative evidence for a link between Peyer's patch development and susceptibility to transmissible spongiform encephalopathies
Q44733047Detection of PrPsc on lymphoid tissues from naturally affected scrapie animals: comparison of three visualization systems
Q48397879Determination of sheep prion gene polymorphisms from paraffin-embedded tissue
Q33394766Epidemiological characteristics of classical scrapie outbreaks in 30 sheep flocks in the United Kingdom.
Q52238026Epidemiology and control of scrapie within a sheep flock.
Q35034201Epigenetic dominance of prion conformers
Q33864486Eradication of scrapie with selective breeding: are we nearly there?
Q35048429Evidence in sheep for pre-natal transmission of scrapie to lambs from infected mothers
Q34709068Evidence of effective scrapie transmission via colostrum and milk in sheep
Q43611477Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep.
Q49081824Experimental transmission of sheep scrapie by intracerebral and oral routes to genetically susceptible Suffolk sheep in the United States
Q45356703Expression patterns of prion protein gene in differential genotypes sheep: quantification using molecular beacon real-time RT-PCR.
Q43589556First case of feline spongiform encephalopathy in a captive cheetah born in France: PrP(sc) analysis in various tissues revealed unexpected targeting of kidney and adrenal gland
Q41110055Genetic evidence for susceptibility and resistance against scrapie in Indian sheep
Q43927597Genetic predisposition of some Bulgarian sheep breeds to the scrapie disease.
Q55262220Genetic profile of scrapie codons 146, 211 and 222 in the PRNP gene locus in three breeds of dairy goats.
Q47160416Genetic resistance to transmissible spongiform encephalopathies (TSE) in goats
Q45412157Genetic variability of PRNP in Chinese indigenous goats.
Q54549682Genetic variability of the PRNP gene in goat breeds from Northern and Southern Italy.
Q48154631Healthy sheep that differ in scrapie associated PRNP genotypes exhibit significant differences of expression pattern associated with immune response and cell-to-cell signalling in retropharyngeal lymph nodes
Q31707696High yield purification and physico-chemical properties of full-length recombinant allelic variants of sheep prion protein linked to scrapie susceptibility
Q30639674Human prion protein sequence elements impede cross-species chronic wasting disease transmission.
Q35122360In vitro conversion of normal prion protein into pathologic isoforms
Q73135653Is scrapie solely a genetic disease?
Q47149313Joint Scientific Opinion on any possible epidemiological or molecular association between TSEs in animals and humans
Q34215388Lack of prion accumulation in lymphoid tissues of PRNP ARQ/ARR sheep intracranially inoculated with the agent of scrapie
Q33307535Lambs with scrapie susceptible genotypes have higher postnatal survival
Q35791567Links between the pathology of Alzheimer's disease and vascular dementia
Q43628872Mapping PrPSc propagation in experimental and natural scrapie in sheep with different PrP genotypes
Q33842432Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine prp.
Q79101379Monte Carlo simulation of surveillance strategies for scrapie in Norwegian sheep
Q34789989Multiplicative genetic effects in scrapie disease susceptibility.
Q80386095Nematode parasites and scrapie: experiments in sheep and mice
Q34542872New in vivo and ex vivo models for the experimental study of sheep scrapie: development and perspectives
Q60089182No maternal transmission?
Q35577970Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock.
Q33569298Ovine reference materials and assays for prion genetic testing
Q34342374Ovine scrapie. New tools for control of an old disease.
Q44168349Phenotyping of protein-prion (PrPsc)-accumulating cells in lymphoid and neural tissues of naturally scrapie-affected sheep by double-labeling immunohistochemistry
Q48823138Plasminogen binds to disease-associated prion protein of multiple species
Q74217836Polymorphic distribution of the ovine prion protein (PrP) gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmissions of scrapie
Q35212371Population dynamics of scrapie in a sheep flock
Q90950356Potential scrapie-associated polymorphisms of the prion protein gene (PRNP) in Korean native black goats
Q41570657PrP genetics in sheep and the applications for scrapie and BSE.
Q36742376PrP genotype frequencies of Quebec sheep breeds determined by real-time PCR and molecular beacons.
Q44227953PrP genotyping of Austrian sheep breeds
Q54938903Predicting the impact of selection for scrapie resistance on PRNP genotype frequencies in goats.
Q28067051Prenatal transmission of scrapie in sheep and goats: A case study for veterinary public health
Q59505923Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer
Q53949785Prion protein (PrP) gene polymorphisms associated with natural scrapie cases and their flock-mates in Ireland.
Q41607634Prion protein and scrapie susceptibility.
Q36914449Prion protein and the transmissible spongiform encephalopathies
Q34304955Prion protein diversity and disease in the transmissible spongiform encephalopathies
Q37589594Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3.
Q83728549Prion protein gene (PrP) polymorphisms in healthy sheep in Turkey
Q28486072Prion protein gene variability in Spanish goats. Inference through susceptibility to classical scrapie strains and pathogenic distribution of peripheral PrP(sc.)
Q46154503Prion protein genotypes of Italian sheep breeds with lysine-171 and phenylalanine-141 detection
Q37373871Prion protein misfolding and disease
Q37949697Prion protein self-interaction in prion disease therapy approaches.
Q30924592Prion protein self-peptides modulate prion interactions and conversion
Q27316704Prion protein-specific antibodies that detect multiple TSE agents with high sensitivity
Q35826534Prionemia and leukocyte-platelet-associated infectivity in sheep transmissible spongiform encephalopathy models.
Q33275397Quantification of Peyer's patches in Cheviot sheep for future scrapie pathogenesis studies
Q51918049Quantifying the risk from ovine BSE and the impact of control strategies.
Q40917691Report of outbreaks of classical scrapie in Dorper sheep and associated prion protein gene polymorphisms in affected flocks
Q42737952Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein
Q30469742Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene.
Q53656966Role of lymph-borne cells in the early stages of scrapie agent dissemination from the skin.
Q47149224Scientific Opinion on BSE/TSE infectivity in small ruminant tissues
Q47147828Scientific Opinion on Risk of transmission of TSEs via semen and embryo transfer in small ruminants (sheep and goats)
Q47152937Scientific Opinion on the risk of transmission of classical scrapie viain vivoderived embryo transfer in ovine animals
Q47154792Scientific Opinion on the scrapie situation in the EU after 10 years of monitoring and control in sheep and goats
Q77154138Scrapie
Q35549003Scrapie and experimental BSE in sheep
Q90929802Scrapie susceptibility-associated indel polymorphism of shadow of prion protein gene (SPRN) in Korean native black goats
Q36763154Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms
Q45974281Scrapie-resistant sheep show certain coat colour characteristics.
Q48319624Sensitivity of the Western blot detection of prion protein PrPres in natural sheep scrapie
Q42666822Sequencing analysis of prion genes from red deer and camel
Q41608529Sex and PRNP genotype determination in preimplantation caprine embryos.
Q37302548Similar biochemical signatures and prion protein genotypes in atypical scrapie and Nor98 cases, France and Norway
Q39588310Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP.
Q36287139Susceptibility to scrapie and disease phenotype in sheep: cross-PRNP genotype experimental transmissions with natural sources
Q64070987The First Report of Polymorphisms and Genetic Features of the Protein Gene () in a Prion Disease-Resistant Animal, Dog
Q52211106The basic reproduction number for scrapie.
Q56556584The first report of polymorphisms and genetic characteristics of the prion protein gene (PRNP) in horses
Q56918235The impact of sheep breed on the risk of classical scrapie
Q34662626The impact of the genotype on the prevalence of classical scrapie at population level
Q33246683The time-course of a scrapie outbreak
Q52070008The transmission dynamics of the aetiological agent of scrapie in a sheep flock.
Q36736581Trends in genotype frequency resulting from breeding for resistance to classical scrapie in Belgium (2006 ˜ 2011).
Q33843366Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model.
Q35141417What would T. H. Huxley have made of prion diseases?
Q35748203[PSI+] Prion transmission barriers protect Saccharomyces cerevisiae from infection: intraspecies 'species barriers'.

Search more.