| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1031381999 |
| P356 | DOI | 10.1038/29073 |
| P698 | PubMed publication ID | 9707118 |
| P50 | author | Hiroshi Takeshima | Q64106482 |
| P2093 | author name string | T Sugimoto | |
| T Takahashi | |||
| T Noda | |||
| Y Noda | |||
| M Nishi | |||
| T Nabeshima | |||
| T Houtani | |||
| T Mamiya | |||
| H Katagiri | |||
| T Manabe | |||
| P2860 | cites work | A synaptic model of memory: long-term potentiation in the hippocampus | Q22337276 |
| Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor | Q24311708 | ||
| Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region | Q28292471 | ||
| The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory | Q28300376 | ||
| Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP | Q28581648 | ||
| Magnesium gates glutamate-activated channels in mouse central neurones | Q29616237 | ||
| Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor | Q30499644 | ||
| Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones | Q34255679 | ||
| Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors | Q45875094 | ||
| Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus | Q46152163 | ||
| Activity-dependent beta-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal CA1 region | Q46233625 | ||
| Structure and regional distribution of nociceptin/orphanin FQ precursor | Q48066088 | ||
| Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons | Q48267434 | ||
| Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice. | Q48489490 | ||
| Functional coupling of the nociceptin/orphanin FQ receptor with the G-protein-activated K+ (GIRK) channel | Q48747818 | ||
| Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats. | Q48806858 | ||
| Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus | Q48884072 | ||
| Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons. | Q48884442 | ||
| Activation of mitogen-activated protein kinase by the nociceptin receptor expressed in Chinese hamster ovary cells. | Q51538753 | ||
| Spatial localization does not require the presence of local cues | Q53952980 | ||
| Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. | Q55063215 | ||
| The orphan opioid receptor and its endogenous ligand — nociceptin/orphanin FQ | Q56591848 | ||
| Different types of calcium channels mediate central synaptic transmission | Q59054415 | ||
| Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation | Q59064768 | ||
| Nociceptin/orphanin FQ activates protein kinase C, and this effect is mediated through phospholipase C/Ca2+ pathway | Q73920417 | ||
| P433 | issue | 6693 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | long-term potentiation | Q1805481 |
| nociceptin | Q4327722 | ||
| P304 | page(s) | 577-581 | |
| P577 | publication date | 1998-08-01 | |
| P1433 | published in | Nature | Q180445 |
| P1476 | title | Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors | |
| P478 | volume | 394 |
| Q34708540 | A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay |
| Q37367805 | A novel series of piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor |
| Q33887997 | A potent and highly selective nonpeptidyl nociceptin/orphanin FQ receptor (ORL1) antagonist: J-113397. |
| Q47549684 | A systematic review of the role of the nociceptin receptor system in stress, cognition, and reward: relevance to schizophrenia. |
| Q35786269 | Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms |
| Q30459631 | Activation of nociceptin/orphanin FQ peptide receptors disrupts visual but not auditory sensorimotor gating in BALB/cByJ mice: comparison to dopamine receptor agonists |
| Q51433695 | Acute desensitization of nociceptin/orphanin FQ inhibition of voltage-gated calcium channels in freshly dissociated hippocampal neurons. |
| Q45249959 | Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice. |
| Q42414217 | Age-related enhancement of a protein synthesis-dependent late phase of LTP induced by low frequency paired-pulse stimulation in hippocampus |
| Q54733725 | Agonist-independent modulation of N-type calcium channels by ORL1 receptors. |
| Q43213776 | Alterations in the level of OFQ/N-IR in rat brain regions by cocaine |
| Q41736471 | An alternatively spliced transcript of the rat nociceptin receptor ORL1 gene encodes a truncated receptor |
| Q42480371 | Antidepressant-like behavior in brain-specific angiogenesis inhibitor 2-deficient mice |
| Q51079468 | Antisense DNA against calcineurin facilitates memory in contextual fear conditioning by lowering the threshold for hippocampal long-term potentiation induction. |
| Q44406474 | Autoradiographic localization of (125)i[Tyr(14)] nociceptin/orphanin FQ binding sites in macaque primate CNS. |
| Q44336675 | Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of mu-, delta- or kappa-opioid receptor knockout mice |
| Q43574489 | Bi-directional modulation of 5-hydroxytryptamine-induced plasma extravasation in the rat knee joint by nociceptin |
| Q42167607 | Binding and GTPgammaS autoradiographic analysis of preproorphanin precursor peptide products at the ORL1 and opioid receptors |
| Q34337014 | Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior. |
| Q104509579 | Blockade of nociceptin/orphanin FQ signaling facilitates an active copying strategy due to acute and repeated stressful stimuli in mice |
| Q46764049 | Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease. |
| Q54652675 | Ca2+/calmodulin-dependent protein kinase II and protein kinase C activities mediate extracellular glucose-regulated hippocampal synaptic efficacy |
| Q38175134 | Calcium-permeable ion channels in pain signaling |
| Q33686284 | Can molecules explain long-term potentiation? |
| Q33665859 | Cellular and molecular mechanisms of memory: the LTP connection |
| Q34040158 | Cellular neurophysiological actions of nociceptin/orphanin FQ. |
| Q34094038 | Central roles of nociceptin/orphanin FQ and nocistatin: allodynia as a model of neural plasticity |
| Q42150123 | Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist |
| Q52177406 | Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS. |
| Q28509205 | Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluRepsilon subunit knockout mice |
| Q40900042 | Combinatorial gene expression using multiple episomal vectors |
| Q46387216 | Defective place cell activity in nociceptin receptor knockout mice with elevated NMDA receptor-dependent long-term potentiation |
| Q44138153 | Degradation of nociceptin (orphanin FQ) by mouse spinal cord synaptic membranes is triggered by endopeptidase-24.11: an in vitro and in vivo study |
| Q31942482 | Designing of an orally active complement C3a agonist peptide with anti-analgesic and anti-amnesic activity |
| Q34990096 | Disruption of persistent nociceptive behavior in rats with learning impairment |
| Q48172353 | Distribution of the nociceptin and nocistatin precursor transcript in the mouse central nervous system |
| Q52024622 | Effect of nociceptin/orphanin FQ on the rewarding properties of morphine. |
| Q52178727 | Effects of nocistatin on nociceptin-induced impairment of learning and memory in mice. |
| Q104666762 | Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation |
| Q34040211 | Effects of supraspinal orphanin FQ/nociceptin |
| Q44352849 | Endogenous delta-opioid and ORL1 receptors couple to phosphorylation and activation of p38 MAPK in NG108-15 cells and this is regulated by protein kinase A and protein kinase C. |
| Q33890990 | Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice |
| Q48560999 | Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor. |
| Q31454582 | Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence. |
| Q28567296 | Enhancement of learning and memory by elevating brain magnesium |
| Q36973583 | Estrogen and progesterone modulate [35S]GTPgammaS binding to nociceptin receptors |
| Q73390724 | Fos expression in feeding-related brain areas following intracerebroventricular administration of orphanin FQ in rats |
| Q28591751 | Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins |
| Q48016277 | Further characterization of the prototypical nociceptin/orphanin FQ peptide receptor agonist Ro 64-6198 in rodent models of conflict anxiety and despair |
| Q34375846 | Gene targeting reveals a role for the glutamate receptors mGluR5 and GluR2 in learning and memory |
| Q27009274 | Genes and signaling pathways involved in memory enhancement in mutant mice |
| Q38122432 | Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory |
| Q89710869 | Hippocampal changes in mice lacking an active prohormone convertase 2 |
| Q42437698 | Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects |
| Q44331522 | Identification of the opioid receptors involved in passive-avoidance learning in the day-old chick during the second wave of neuronal activity |
| Q47657778 | Impact of environmental housing conditions on the emotional responses of mice deficient for nociceptin/orphanin FQ peptide precursor gene |
| Q28586975 | Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice |
| Q36080560 | Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice |
| Q52027240 | Improvement by low doses of nociceptin on scopolamine-induced impairment of learning and/or memory. |
| Q41990054 | In vitro and ex vivo effects of a selective nociceptin/orphanin FQ (N/OFQ) peptide receptor antagonist, CompB, on specific binding of [3H]N/OFQ and [35S]GTPgammaS in rat brain and spinal cord |
| Q43668141 | Influence of the selective ORL1 receptor agonist, Ro64-6198, on rodent neurological function. |
| Q46177333 | Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. |
| Q46474494 | Injection of orphanin FQ/nociceptin into the periaqueductal gray suppresses the forebrain-elicited vocalization in the guinea pig. |
| Q44213529 | Involvement of the neuropeptide nociceptin/orphanin FQ in kainate seizures. |
| Q45067530 | Kainate seizures increase nociceptin/orphanin FQ release in the rat hippocampus and thalamus: a microdialysis study. |
| Q40011278 | Kainic acid down-regulates NOP receptor density and gene expression in human neuroblastoma SH-SY5Y cells. |
| Q28591699 | Lack of the nociceptin receptor does not affect acute or chronic nociception in mice |
| Q33885107 | Linking Hebb's coincidence-detection to memory formation |
| Q44287843 | Long-term potentiation in the hippocampal CA1 area and dentate gyrus plays different roles in spatial learning |
| Q43070570 | Memory mechanisms: the nociceptin connection |
| Q51082411 | Modest neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene. |
| Q46828882 | Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus. |
| Q33842573 | Molecular and cellular mechanisms of cognitive function: implications for psychiatric disorders |
| Q33632550 | Molecular mechanisms of synaptic plasticity and memory. |
| Q48569616 | Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. |
| Q47891165 | Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury |
| Q38283275 | Neuromodulatory signaling in hippocampus-dependent memory retrieval |
| Q44531024 | Neuronal mechanism of nociceptin-induced modulation of learning and memory: involvement of N-methyl-D-aspartate receptors |
| Q50735967 | Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA. |
| Q30453815 | Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y. |
| Q24647788 | Neuropeptides in depression: role of VGF |
| Q38217456 | Neuropeptides: metabolism to bioactive fragments and the pharmacology of their receptors |
| Q35003042 | New life in an old idea: the synaptic plasticity and memory hypothesis revisited |
| Q28257948 | Nociceptin and the nociceptin receptor in learning and memory |
| Q46729664 | Nociceptin receptor impairs recognition memory via interaction with NMDA receptor-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in the hippocampus |
| Q36744366 | Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems |
| Q28343438 | Nociceptin/orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice |
| Q43916448 | Nociceptin/orphanin FQ and opioid receptor-like receptor mRNA expression in dopamine systems |
| Q44328327 | Nociceptin/orphanin FQ knockout mice display up-regulation of the opioid receptor-like 1 receptor and alterations in opioid receptor expression in the brain |
| Q58545262 | Nociceptin/orphanin FQ receptor ligands and translational challenges: focus on cebranopadol as an innovative analgesic |
| Q52166329 | Nocistatin inhibits food intake in rats. |
| Q34040233 | Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor |
| Q37897596 | Novel neuropeptides as ligands of orphan G protein-coupled receptors |
| Q48268063 | Orexin-A (hypocretin-1) impairs Morris water maze performance and CA1-Schaffer collateral long-term potentiation in rats |
| Q35039435 | Orphanin FQ suppresses NMDA receptor-dependent long-term depression and depotentiation in hippocampal dentate gyrus |
| Q51422135 | Orphanin FQ-induced outward current in rat hippocampus. |
| Q40798965 | Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation. |
| Q36499488 | Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats |
| Q35720961 | Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidation |
| Q33959588 | Orphanin FQ/nociceptin not only blocks but also reverses behavioral adaptive changes induced by repeated cocaine in mice |
| Q50303585 | Outcome of array CGH analysis for 255 subjects with intellectual disability and search for candidate genes using bioinformatics |
| Q28178485 | Peptide and nonpeptide ligands for the nociceptin/orphanin FQ receptor ORL1: research tools and potential therapeutic agents |
| Q73943309 | Peripheral modulation of rat knee joint afferent mechanosensitivity by nociceptin/orphanin FQ |
| Q44796542 | Pharmacological profile of nociceptin/orphanin FQ receptors regulating 5-hydroxytryptamine release in the mouse neocortex |
| Q24675084 | Pharmacology of nociceptin and its receptor: a novel therapeutic target |
| Q47350210 | Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis. |
| Q43656813 | Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene |
| Q73575596 | Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation |
| Q37381103 | Review of recent advances in analytical techniques for the determination of neurotransmitters |
| Q34040215 | Role of nociceptin systems in learning and memory. |
| Q51715971 | Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand. |
| Q43770928 | Spontaneous transient outward currents: modulation by nociceptin in murine dentate gyrus granule cells |
| Q35669512 | Structural requirements of N-substituted spiropiperidine analogues as agonists of nociceptin/orphanin FQ receptor |
| Q31119101 | Structural requirements of nociceptin antagonist Ac-RYYRIK-NH2 for receptor binding. |
| Q57951324 | Structure–activity studies on nociceptin/orphanin FQ: from full agonist, to partial agonist, to pure antagonist |
| Q43801210 | Synthesis and in vivo evaluation of [11C]methyl-Ro 64-6198 as an ORL1 receptor imaging agent |
| Q57073139 | Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile |
| Q34525952 | Target validation of G-protein coupled receptors |
| Q35623039 | Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice |
| Q59800566 | The Nociceptin Receptor (NOP) Agonist AT-312 Blocks Acquisition of Morphine- and Cocaine-Induced Conditioned Place Preference in Mice |
| Q34510753 | The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction |
| Q41889844 | The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands |
| Q74269203 | The effect of [Phe(1)psi(CH(2)-NH)Gly(2)]-nociceptin(1-13)NH(2) on feeding and c-Fos immunoreactivity in selected brain sites |
| Q48838669 | The facilitative effects of bilobalide, a unique constituent of Ginkgo biloba, on synaptic transmission and plasticity in hippocampal subfields |
| Q34134388 | The immune system and memory consolidation: a role for the cytokine IL-1beta. |
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| Q48180760 | The neuropeptide nociceptin is a synaptically released endogenous inhibitor of hippocampal long-term potentiation. |
| Q34040126 | The orphanin FQ/nociceptin gene: structure, tissue distribution of expression and functional implications obtained from knockout mice |
| Q30816632 | The promoter region of human prepro-nociceptin gene and its regulation by cyclic AMP and steroid hormones |
| Q36840304 | The role of NOP receptors in psychomotor stimulation and locomotor sensitization induced by cocaine and amphetamine in mice |
| Q52030171 | The role of nociceptin in cognition. |
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| Q89599708 | Transcriptomics of Gabra4 knockout mice reveals common NMDAR pathways underlying autism, memory, and epilepsy |
| Q37760247 | UFP-112 a potent and long-lasting agonist selective for the Nociceptin/Orphanin FQ receptor |
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| Q43264416 | [Nphe(1)]-Nociceptin (1-13)-NH(2), a nociceptin receptor antagonist, reverses nociceptin-induced spatial memory impairments in the Morris water maze task in rats |
| Q43929869 | [Nphe1]nociceptin(1-13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat. |
| Q39538303 | ∆(9)-Tetrahydrocannabinol decreases NOP receptor density and mRNA levels in human SH-SY5Y cells. |
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