Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor γ coactivator-1α-deficient mice.

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Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor γ coactivator-1α-deficient mice. is …
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scholarly articleQ13442814

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P356DOI10.1113/EP086629
P932PMC publication ID5832578
P698PubMed publication ID29215172

P50authorJohn ThyfaultQ37837332
Ryan D SheldonQ57344169
Justin A FletcherQ63897387
R Scott RectorQ75438426
E Matthew MorrisQ80283138
Melissa A LindenQ80352720
Grace M E MeersQ114314682
James W PerfieldQ114314683
P2093author name stringAnthony Butterfield
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Changes in skeletal muscle mitochondria in response to the development of type 2 diabetes or prevention by daily wheel running in hyperphagic OLETF ratsQ28580733
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic statesQ29615208
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FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.Q34315567
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PGC-1α overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion.Q36312713
FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the LiverQ36588765
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Fibroblast growth factor 21: an overview from a clinical perspectiveQ37412337
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Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activationQ38302923
Fibroblast growth factor 21 reverses suppression of adiponectin expression via inhibiting endoplasmic reticulum stress in adipose tissue of obese miceQ38733095
Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins.Q39297379
Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit RatsQ39350536
Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.Q40958865
Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis.Q41630408
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The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscleQ42453678
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese miceQ43224118
The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.Q46445480
Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats.Q46823988
Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeysQ46844955
FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fastingQ48659709
Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver.Q51369626
FGF21: a missing link in the biology of fasting.Q51470091
Dual effects of fibroblast growth factor 21 on hepatic energy metabolism.Q51741443
Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.Q53514538
Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjectsQ58456009
Energy cost of gluconeogenesis in rat liverQ68750160
Exercise-induced rise in glucagon and ketogenesis during prolonged muscular workQ69370044
The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humansQ86752708
P433issue3
P304page(s)408-418
P577publication date2018-01-16
P1433published inExperimental PhysiologyQ1091760
P1476titleFibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor γ coactivator-1α-deficient mice
P478volume103