Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei

scientific article published on 8 September 2017

Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M117.807495
P8608Fatcat IDrelease_qcd45l7f3jeinjvdv3jqhw6kqa
P932PMC publication ID5672039
P698PubMed publication ID28887303

P2093author name stringJames H Prestegard
Roberto Docampo
S Khan Hekmatyar
Ciro D Cordeiro
You Zhuo
P2860cites workDynamic nuclear polarization of deuterated proteinsQ40788089
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Hydrophobic radicals embedded in neutral surfactants for dynamic nuclear polarization of aqueous environments at 9.4 TeslaQ58357556
Probing treatment response of glutaminolytic prostate cancer cells to natural drugs with hyperpolarized [5-13C]glutamineQ58830269
Sulfite Action in Glycolytic Inhibition: In Vivo Real-Time Observation by Hyperpolarized13C NMR SpectroscopyQ58851870
Mitochondrial fatty acid synthesis in Trypanosoma bruceiQ61490585
Production of aromatic alpha-hydroxyacids by epimastigotes of Trypanosoma cruzi, and its possible role in NADH reoxidationQ72021037
Formulation and utilization of choline based samples for dissolution dynamic nuclear polarizationQ85773179
Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMRQ24683340
Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused OrgansQ26781659
A pyruvate-proton symport and an H+-ATPase regulate the intracellular pH of Trypanosoma brucei at different stages of its life cycleQ28343896
Revisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viabilityQ28537756
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Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.Q34007874
NMR and pattern recognition methods in metabolomics: from data acquisition to biomarker discovery: a reviewQ34444673
Proteome remodelling during development from blood to insect-form Trypanosoma brucei quantified by SILAC and mass spectrometryQ34445858
NMR spectroscopy for metabolomics and metabolic profiling.Q34446558
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Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor.Q35958087
Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO.Q36004030
Probing alanine transaminase catalysis with hyperpolarized 13CD3-pyruvateQ36846483
Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized (13)C pyruvate magnetic resonanceQ36926275
Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporterQ37404480
Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypesQ37511779
Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cellsQ37608570
Sleeping sicknessQ37896705
NMR insights into the inner workings of living cellsQ38236005
Studies of Metabolism Using (13)C MRS of Hyperpolarized Probes.Q38584558
On the present and future of dissolution-DNP.Q38902738
Ablation of succinate production from glucose metabolism in the procyclic trypanosomes induces metabolic switches to the glycerol 3-phosphate/dihydroxyacetone phosphate shuttle and to proline metabolism.Q39668573
Voxel-by-voxel correlations of perfusion, substrate, and metabolite signals in dynamic hyperpolarized (13) C imagingQ39687843
P433issue44
P407language of work or nameEnglishQ1860
P921main subjectTrypanosoma bruceiQ33244
P304page(s)18161-18168
P577publication date2017-09-08
P1433published inJournal of Biological ChemistryQ867727
P1476titleDynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei
P478volume292

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cites work (P2860)
Q61510374Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of
Q46275544Perdeuterated and 13C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase

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