Searching for Correlations Between the Development of Neurodegenerative Hallmarks: Targeting Huntingtin as a Contributing Factor

scientific article published in January 2017

Searching for Correlations Between the Development of Neurodegenerative Hallmarks: Targeting Huntingtin as a Contributing Factor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/978-3-319-57379-3_24
P698PubMed publication ID28971465

P2093author name stringNelina P Angelova
P2860cites workModeling the mitochondrial dysfunction in neurogenerative diseases due to high H+ concentrationQ42122769
Altered proteasomal function in sporadic Parkinson's diseaseQ44264446
Late-onset Huntington disease with intermediate CAG repeats: true or false?Q45296632
Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtinQ45297269
Huntington's disease is a four-repeat tauopathy with tau nuclear rods.Q45300275
The association of CAG repeat length with clinical progression in Huntington diseaseQ45300690
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.Q45302702
Autopsy-proven Huntington's disease with 29 trinucleotide repeatsQ45303229
Mitochondrial dynamics and mitophagy in Parkinson's disease: A fly point of viewQ46642004
Different species of alpha-synuclein oligomers induce calcium influx and seeding.Q52581429
Huntingtin interacting proteins are genetic modifiers of neurodegenerationQ21145230
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcriptionQ22254119
Interaction of Huntington disease protein with transcriptional activator Sp1Q24537687
Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotectionQ24650675
It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer DiseaseQ26765816
Alterations in Mitochondrial Quality Control in Alzheimer's DiseaseQ26768215
Structural Basis of E2-25K/UBB+1 Interaction Leading to Proteasome Inhibition and NeurotoxicityQ27664383
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Q27860836
Huntingtin functions as a scaffold for selective macroautophagyQ28118022
Loss of huntingtin-mediated BDNF gene transcription in Huntington's diseaseQ28202050
REST and stress resistance in ageing and Alzheimer's diseaseQ28236857
The role of mTOR signaling in Alzheimer diseaseQ28256247
The role of autophagy in age-related neurodegenerationQ28261965
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington diseaseQ28261987
The roles of intracellular protein-degradation pathways in neurodegenerationQ28269322
Protein aggregation and neurodegenerative diseaseQ28273600
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotesQ28302701
Inhibition of mitochondrial protein import by mutant huntingtinQ28394803
Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neuronsQ28575380
The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradationQ28591685
Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivoQ30494325
Cargo recognition failure is responsible for inefficient autophagy in Huntington's diseaseQ33814719
Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.Q36623762
An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1.Q36647206
Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.Q36854847
Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent mannerQ36981055
Huntingtin as an essential integrator of intracellular vesicular traffickingQ37408730
Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.Q37839534
Mitochondrial dynamics and quality control in Huntington's disease.Q38590033
Brain REST/NRSF Is Not Only a Silent Repressor but Also an Active ProtectorQ38689612
Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.Q39333674
Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c releaseQ40551652
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.Q40721588
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's diseaseQ40887263
The Aggregation of Huntingtin and α-SynucleinQ41834257
P407language of work or nameEnglishQ1860
P921main subjectneurodegenerationQ1755122
P1104number of pages13
P304page(s)269-281
P577publication date2017-01-01
P1433published inAdvances in Experimental Medicine and BiologyQ4686385
P1476titleSearching for Correlations Between the Development of Neurodegenerative Hallmarks: Targeting Huntingtin as a Contributing Factor
P478volume987

Search more.