scholarly article | Q13442814 |
P356 | DOI | 10.1016/0002-9343(66)90200-2 |
P698 | PubMed publication ID | 4956871 |
P2093 | author name string | R T McCluskey | |
E C Franklin | |||
N Cooper | |||
M Meltzer | |||
K Elias | |||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | laboratory | Q483242 |
P304 | page(s) | 837-856 | |
P577 | publication date | 1966-06-01 | |
P1433 | published in | American Journal of Medicine | Q2842959 |
P1476 | title | Cryoglobulinemia--a clinical and laboratory study. II. Cryoglobulins with rheumatoid factor activity | |
P478 | volume | 40 |
Q71463250 | A case of adult coeliac disease with Addison's disease. Presented at the Royal Postgraduate Medical School |
Q69361136 | A case of purpura hyperglobulinaemica of Waldenstrom studied by skin immunofluorescence |
Q84389612 | A comparison of performance of anti-cyclic citrullinated peptide 2 and citrullinated protein antibodies in the diagnosis of rheumatoid arthritis in Iranian patients |
Q70079163 | A distinctive glomerular lesion complicating placental site trophoblastic tumor: report of two cases |
Q93801086 | A lambda light chain cold agglutinin-cryomacroglobulin occurring in Waldenström's macroglobulinemia |
Q41035779 | A literary review on ice therapy in injuries |
Q43985522 | A reversible neutrophil bactericidal defect associated with a mixed cryoglobulin |
Q27473447 | Active hepatitis C virus infection in bone marrow and peripheral blood mononuclear cells from patients with mixed cryoglobulinaemia |
Q34364171 | An interesting rash: leucocytoclastic vasculitis with type 2 cryoglobulinaemia. |
Q40919365 | Anti-endothelial cell auto-antibodies in hepatitis C virus mixed cryoglobulinemia |
Q42986062 | Antibodies against hepatitis C virus in mixed cryoglobulinemia patients |
Q39574748 | Antibodies to a new viral citrullinated peptide, VCP2: fine specificity and correlation with anti-cyclic citrullinated peptide (CCP) and anti-VCP1 antibodies. |
Q27473547 | Antibodies to hepatitis C virus in essential mixed cryoglobulinaemia |
Q30501084 | Antiglobulins and glomerulonephritis. Classification of patients by the reactivity of their sera and renal tissue with aggregated and native human IgG |
Q70099544 | Antinuclear antibodies in cryoglobulinaemic diseases |
Q39235935 | Arthritis and hepatitis |
Q70777310 | Articular manifestations of essential cryoglobulinemia |
Q41175619 | Assessment of free light chains in HCV-positive patients with mixed cryoglobulinaemia vasculitis undergoing rituximab treatment. |
Q38884955 | Association of BAFF -871C/T Promoter Polymorphism with Hepatitis C-Related Mixed Cryoglobulinemia in a Cohort of Egyptian Patients |
Q72429160 | Autoantibodies from mixed cryoglobulinaemia patients bind glomerular antigens |
Q27026174 | Autoimmunity and infection in Sjögren's syndrome |
Q50588813 | Beneficial effect of ribavirin on hepatitis C-associated cryoglobulinemia after liver transplantation. |
Q36819743 | Bilateral forefoot ischemia as a premonitory symptom of mixed cryoglobulinemia |
Q54402575 | Binding properties of monoclonal gammaG-antiglobulin factors with human gamma G. |
Q36934322 | Biologic agents in systemic vasculitis. |
Q35940411 | Biologic properties and detection of immune complexes in animal and human pathology |
Q70099541 | Blood potassium, glucose, and insulin in patients undergoing peritoneal dialysis and haemodialysis |
Q42978154 | Bone marrow findings further support the hypothesis that essential mixed cryoglobulinemia type II is characterized by a monoclonal B-cell proliferation |
Q39402531 | Case for diagnosis: leukocytoclastic vasculitis |
Q40099979 | Characterization of cryoprecipitates in pemphigus: demonstration of pemphigus antibody activity in cryoprecipitates using the immunofluorescent technique |
Q41256784 | Chronic glomerular nephritis in a man with an IgM cold autoantibody of anti-I specificity and a cold lymphocytotoxic antibody |
Q34475111 | Chronic hepatitis and cirrhosis of the liver in cryoglobulinaemia |
Q40328862 | Circulating immune complexes in dermatologic disease |
Q40657247 | Circulating immune complexes in systemic lupus erythematosus |
Q39487492 | Clearance of cryoglobulins in man. |
Q53779976 | Clinical implications of monoclonal gammopathy in chronic liver disease. |
Q35553110 | Clinical utility of the anti-CCP assay in patients with rheumatic diseases |
Q43432949 | Clinically significant renal involvement in primary Sjögren's syndrome: clinical presentation and outcome |
Q69740105 | Clonal B cell expansions in patients with essential mixed cryoglobulinaemia |
Q34474503 | Coeliac disease, vasculitis, and cryoglobulinaemia |
Q27470018 | Compartmentalization of hepatitis C virus quasispecies in blood mononuclear cells of patients with mixed cryoglobulinemic syndrome |
Q33584134 | Complement factor 2 deficiency: a clinical and serological family study |
Q36248082 | Complete sequence of the genes encoding the VH and VL regions of low- and high- affinity monoclonal lgM and lgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient |
Q39638743 | Cryocrystalglobulinemia in hairy cell leukemia |
Q59355453 | Cryoglobulinaemia |
Q70134553 | Cryoglobulinaemia and intermittent nephrotic syndrome |
Q53867082 | Cryoglobulinaemia and nephritis. |
Q35547638 | Cryoglobulinaemia and rheumatic manifestations in patients with hepatitis C virus infection |
Q47922558 | Cryoglobulinaemia in human renal diseases. A study of seventy-six cases |
Q44620869 | Cryoglobulinaemia in patients with infectious endocarditis |
Q33811619 | Cryoglobulinemia |
Q74514123 | Cryoglobulinemia due to chronic viral hepatitis infections is not a major problem in clinical practice |
Q43820743 | Cryoglobulinemia is associated with steatosis and fibrosis in chronic hepatitis C. |
Q36767655 | Cryoglobulinemia related to hepatitis C virus infection |
Q71854359 | Cryoglobulinemic peripheral neuropathy: neurophysiologic evaluation in twenty-two patients |
Q91708745 | Cryoglobulinemic vasculitis and glomerulonephritis: concerns in clinical practice |
Q24673191 | Cryoglobulins |
Q42990339 | Cryoglobulins and cryoglobulinemia. Diagnostic and therapeutic considerations |
Q35547463 | Cryoglobulins are not essential |
Q93623789 | Cryoglobulins in cases of rheumatoid arthritis |
Q52945388 | Cryoglobulins in glomerulonephritis not related to systemic disease. |
Q42209784 | Cryoglobulins in nonalcoholic Fatty-liver disease: what is the association? |
Q44369619 | Cryoglobulins in vasculitis |
Q39369439 | Cryoglobulins. |
Q41039063 | Cryoimmunoglobulinaemia in patients with primary renal disease and systemic lupus erythematosus. I. IgG- and DNA-binding assessed by co-precipitation |
Q34482070 | Cryoimmunoglobulinemia in rheumatoid arthritis. Significance in serum of patients with rheumatoid vasculitis |
Q40088211 | Cutaneous and systemic manifestations of auto-immune disorders |
Q39850436 | Cutaneous immunopathology. The diagnostic use of direct and indirect immunofluorescence techniques in dermatologic disease |
Q42468413 | Deafness in cryoglobulinemia |
Q70553897 | Deposits of immunoglobulins and C3 in the walls of human renal arteries |
Q93803311 | Diagnosis of Syndromes Associated With Hyperglobulinemia |
Q52125181 | Distribution of rheumatoid factor activity in nonrheumatoid states |
Q33928614 | Do vasculitis categorization systems really matter? |
Q66920891 | Early complement component depletion and mixed cryoglobulinemia in a “healthy” family |
Q44990800 | Effect of 51p1-related gene copy number (V1-69 locus) on production of hepatitis C-associated cryoglobulins |
Q36602896 | Erroneous values for the total white cell count and ESR in patients with cryoglobulinaemia |
Q41871677 | Essential mixed cryoglobulinaemia with false-positive serological tests for syphilis. |
Q39992134 | Evidence for immunologic mechanisms in several forms of human glomerular diseases. |
Q67266691 | Experimental cryoglobulinaemia. Production and properties of streptococcus-induced rabbit cryoglobulins |
Q39735380 | Extraglomerular immunoglobulin deposits in human nephritis |
Q36410569 | Extrahepatic manifestations of hepatitis C virus |
Q38155023 | Fever in various rheumatic diseases |
Q71079973 | Glomerular Disease in Two Patients With Urticaria-Cutaneous Vasculitis and Hypocomplementemia |
Q39871087 | Glomerular lesions in dysproteinemias |
Q35830620 | Glomerular lesions induced in the rabbit by physicochemically altered homologous IgG |
Q72106524 | Glomerular localization of circulating antiglobulin activity in essential mixed cryoglobulinemia with glomerulonephritis |
Q40649380 | HLA-B8 and clinical features of Sjogren's syndrome |
Q47885889 | Heavy chain disease, rheumatoid arthritis and cryoglobulinemia |
Q42984394 | Hepatic lymphoid aggregates in chronic hepatitis C and mixed cryoglobulinemia |
Q38497354 | Hepatitis C virus and autoimmunity |
Q36496970 | Hepatitis C virus and its renal manifestations: a review and update |
Q40857968 | Hepatitis C virus and mixed cryoglobulinaemia |
Q26775007 | Hepatitis C virus and non-Hodgkin's lymphomas: Meta-analysis of epidemiology data and therapy options |
Q35731058 | Hepatitis C virus as a multifaceted disease: a simple and updated approach for extrahepatic manifestations of hepatitis C virus infection |
Q38003148 | Hepatitis C virus cryoglobulinemia and non-hodgkin lymphoma |
Q42989326 | Hepatitis C virus genotypes and clinical features in hepatitis C virus-related mixed cryoglobulinemia |
Q38057221 | Hepatitis C virus infection and autoimmune diseases |
Q41560603 | Hepatitis C virus infection and its rheumatologic implications |
Q42980534 | Hepatitis C virus infection and mixed cryoglobulinaemia: assessment of HCV RNA copy numbers in supernatant, cryoprecipitate and non-liver cells |
Q37057403 | Hepatitis C virus infection induced vasculitis |
Q35237312 | Hepatitis C virus syndrome: A constellation of organ- and non-organ specific autoimmune disorders, B-cell non-Hodgkin's lymphoma, and cancer |
Q37288114 | Hepatitis C virus, cryoglobulinemia, and kidney: novel evidence |
Q33363781 | Hepatitis C virus-associated extrahepatic manifestations: a review |
Q37527686 | Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies |
Q37371397 | Hepatitis C virus-induced cryoglobulinemia |
Q38127143 | Hepatitis C virus-induced vasculitis: therapeutic options. |
Q42984600 | Hepatitis-C-associated cryoglobulinemia after liver transplantation |
Q71181628 | High binding of immunoglobulin M kappa rheumatoid factor from type II cryoglobulins to cellular fibronectin: a mechanism for induction of in situ immune complex glomerulonephritis? |
Q39869159 | Human immunoglobulins: classes, subclasses, genetic variants, and idiotypes |
Q34278009 | Human monoclonal gamma G-cryoglobulins with anti-gamma-globulin activity |
Q40474287 | Hypercatabolism of normal IgG; an unexplained immunoglobulin abnormality in the connective tissue diseases |
Q41883458 | Identification of glomerular immune deposits in cryoglobulinemia glomerulonephritis |
Q44064034 | IgA and autoimmunity |
Q27473439 | IgM and IgG antibodies to hepatitis C virus in patients with mixed cryoglobulinaemia |
Q72166075 | IgM-IgG cryoglobulinaemia with IgM paraprotein component |
Q39941757 | Immune Complex Disease in Experimental Animals and Man |
Q93831460 | Immune complex cryoglobulinaemia in lepromatous leprosy: a pathogenetic approach to some clinical features of leprosy |
Q39906398 | Immune complex diseases |
Q39854606 | Immune complex glomerulonephritis in sicca syndrome |
Q39847158 | Immune complex mediated diseases |
Q33551263 | Immune reactants in cryoproteins. Relationship to complement activation |
Q39978581 | Immune-Complex Disease |
Q67241371 | Immunochemical studies of an immunoglobulin M-immunoglobulin G mixed cryoglobulin |
Q47755462 | Immunofluorescent studies of the skin in cryoglobulinaemic vasculitis |
Q36347411 | Immunoglobulin M-Immunoglobulin G mixed cryoglobulinemia in Schistosoma japonicum-infected rabbits |
Q40015944 | Immunoglobulins in Clinical Chemistry |
Q69384192 | Immunologic events preceding clinical exacerbation of systemic lupus erythematosus |
Q53909308 | Immunological and physicochemical studies of IgA1 (delta) cryogelglobulinaemia. |
Q40312484 | Immunopathogenesis of the extrahepatic manifestations of hepatitis B virus infection. |
Q39923325 | Immunosuppression — Agents, Procedures, Speculations and Prognosis |
Q39291060 | Immunosuppressive and corticosteroid therapy of polyarteritis nodosa |
Q70249935 | In situ immune complex formation in the mouse glomerulus: reactivity with human IgM rheumatoid factor and the effect on subsequent immune complex deposition |
Q45735396 | Influence of HLA-DR phenotype on the risk of hepatitis C virus-associated mixed cryoglobulinemia |
Q35201733 | Inheritance of mixed cryoglobulinemia |
Q71395059 | Interaction of plasma fibronectin with selected cryoglobulins |
Q39433071 | Laboratory Tests in Rheumatic Diseases |
Q37877205 | Laboratory testing for cryoglobulins |
Q33560679 | Large quantities of low molecular weight IgM in mixed cryoglobulinaemia |
Q42566872 | Lesson from an intriguing case of cryoglobulinemia |
Q39900773 | Light and electron microscopic findings in five cases of cryoglobulinemic glomerulonephritis |
Q67002290 | Liver involvement in essential mixed cryoglobulinemia |
Q70333026 | Localization of Preformed, Circulating Immune Complexes in Murine Skin |
Q69801495 | Low-antigen-content diet in the treatment of patients with mixed cryoglobulinemia |
Q41599720 | Lung involvement in essential mixed cryoglobulinemia |
Q33556496 | Lymphocyte subpopulations in essential mixed cryoglobulinaemia |
Q43053520 | Mixed cryoglobulinaemia after hepatitis C virus: more and less ambiguity |
Q74714057 | Mixed cryoglobulinaemia: a cross-road between autoimmune and lymphoproliferative disorders |
Q36942539 | Mixed cryoglobulinemia |
Q41519669 | Mixed cryoglobulinemia as a model of systemic vasculitis |
Q41201723 | Mixed cryoglobulinemia secondary to hepatitis C virus infection |
Q72235166 | Mixed cryoimmunoglobulins |
Q37096035 | Mixed or immune complex cryoglobulinaemia and neuropathy |
Q39604994 | Molecular basis for cryoprecipitation |
Q72418478 | Monoclonal and polyclonal gamma M rheumatoid factors with anti-di- and anti-trinitrophenyl activity |
Q68988831 | Monoclonal antibodies to restricted and cross-reactive idiotopes on monoclonal rheumatoid factors and their recognition of idiotope-positive cells |
Q66939709 | Monoclonal immunoglobulinaemia associated with glomerulopathy |
Q36334988 | Monoclonal macroglobulinemia in NZB-NZW F1 mice |
Q41893360 | Multiple myeloma presenting as cryoglobulinaemia |
Q35875118 | Naturally occurring immune-complex glomerulonephritis in monkeys (Macaca irus). I. Light, immunofluorescence and electron microscopic studies |
Q67449423 | Nephrotic syndrome complicating connective tissue disease |
Q45754354 | No evidence for abnormal immune activation in peripheral blood T cells in patients with hepatitis C virus (HCV) infection with or without cryoglobulinaemia. Multivirc Group |
Q81440372 | Non HCV-related mixed cryoglobulinemia |
Q43662488 | Non-specific stimulation of immunoglobulin synthesis in mice by capsular polysaccharide of Klebsiella pneumoniae |
Q46841257 | Pancytopenia with mixed cryoglobulinemia: evidence for anti-percursor cell activity of cryoglobulin--effects of plasmapheresis |
Q71267774 | Paraproteinemia and cryoglobulinemia associated with atypical glomerulonephritis and the nephrotic syndrome |
Q41771952 | Parvovirus B19 infection, hepatitis C virus infection, and mixed cryoglobulinaemia |
Q71480586 | Pathogenesis of nephrosis |
Q71596601 | Pathogenic role of a monoclonal IgA (kappa ) anti-IgG paraprotein associated with hemorrhagic diathesis, rheumatoid arthritis, vascular purpura, and acute membranoproliferative glomerulonephritis |
Q39606577 | Pathology of dysproteinemia: light chain amyloidosis, non-amyloid immunoglobulin deposition disease, cryoglobulinemia syndromes, and macroglobulinemia of Waldenström |
Q33407192 | Peg-IFNα/ribavirin/protease inhibitor combination in hepatitis C virus associated mixed cryoglobulinemia vasculitis: results at week 24 |
Q37591062 | Physicochemical characterization of six monoclonal cryoimmunoglobulins: possible basis for cold-dependent insolubility |
Q33552844 | Plasma fibronectin is a component of cryoglobulins from patients with connective tissue and other diseases |
Q41609352 | Polymyositis with plasma cell infiltrate in essential mixed cryoglobulinaemia |
Q92741709 | Predictive factors of renal involvement in cryoglobulinaemia: a retrospective study of 153 patients |
Q27477924 | Prevalence and clinical features of cryoglobulinaemia in multitransfused beta-thalassaemia patients |
Q45368252 | Prognostic factors in patients with hepatitis C virus infection and systemic vasculitis. |
Q34118568 | Progress in the use of biochemical and biological markers for evaluation of rheumatoid arthritis. |
Q67233569 | Protein-induced bleeding |
Q43705395 | Reactions of Aggregated Mercaptoethanol Treated Gamma Globulin with Rheumatoid Factor Precipitin and Complement Fixation Studies |
Q39519978 | Reappraisal of the clinical expression of mixed cryoglobulinemia |
Q72789996 | Relationship of tissue deposits of cryoglobulin to clinical features of mixed cryoglobulinemia |
Q53926597 | Renal hypertension and renoportal anastomosis. |
Q93747767 | Renal involvement in essential cryoglobulinaemia |
Q38620434 | Renal involvement in essential mixed cryoglobulinemia |
Q68192757 | Renal involvement in essential mixed cryoglobulinemia |
Q40771010 | Renal localization of antiglobulins in glomerulonephritis and after renal transplantation |
Q70959880 | Respiratory Insufficiency in a Patient with Mixed Cryoglobulinemia |
Q35355811 | Response to interferon alpha treatment and disappearance of cryoglobulinaemia in patients infected by hepatitis C virus |
Q70468611 | Rheumatoid arthritis associated with transient gamma 2-heavy chain disease |
Q71443200 | Rheumatoid arthritis terminating in plasmocytoma |
Q54065208 | Rheumatoid factor and the fixation of complement. |
Q93692210 | Rheumatoid hyperviscosity syndrome |
Q47850502 | Rheumatoid hyperviscosity: analysis of a patient with intermediate complexes that block other autoantibodies and a review of the literature |
Q37893529 | Rheumatologic manifestations of benign and malignant haematological disorders. |
Q37083399 | Rituximab as a therapeutic tool in severe mixed cryoglobulinemia |
Q37807326 | Rituximab in cryoglobulinaemic vasculitis, evidence for its effectivity: a case report and review of literature. |
Q51051418 | Role of monocytes in cryoglobulinemia-associated nephritis. |
Q69816084 | Self-induced glomerulonephritis |
Q36349223 | Sequence similarities among kappa IIIb chains of monoclonal human IgM kappa autoantibodies |
Q47689253 | Serological heterogeneity of the IgM components of mixed (monoclonal IgM-polyclonal IgG) cryoglobulins |
Q43478912 | Serum complement pattern in essential mixed cryoglobulinaemia |
Q45259824 | Severe, refractory type II essential mixed cryoglobulinemia treated with 2-chlorodeoxyadenosine and mycophenolate mofetil |
Q33557529 | Sjögren's syndrome, vasculitis, and cryoglobulinaemia associated with a monoclonal IgM (kappa) paraprotein with rheumatoid factor activity |
Q70033141 | Skin lesions, angio-oedema, and hypocomplementaemia |
Q55449137 | Sofosbuvir–daclatasvir improves hepatitis C virus–induced mixed cryoglobulinemia: Upper Egypt experience. |
Q40217274 | Soluble immune complexes in human disease |
Q54327864 | Some factors affecting precipitation and complex formation of an IgG cryoglobulin. |
Q41235985 | Some properties of monoclonal cryoglobulin m appearing in the course of malignant lymphoma with macroglobulinemia |
Q66880770 | Specific concentration of antilymphocyte antibodies in the serum cryoprecipitates of patients with systemic lupus erythematosus |
Q34481102 | Specific concentration of polynucleotide immune complexes in the cryoprecipitates of patients with systemic lupus erythematosus |
Q34669793 | Specificity of squamous cell carcinoma antigen (SCCA)-IgM detection in patients with HCV infection and rheumatoid factor seropositivity. |
Q33556797 | Spontaneous and pokeweed mitogen induced production of rheumatoid factor and immunoglobulins in type II essential mixed cryoglobulinaemia |
Q34267606 | Studies of cryoproteins in systemic lupus erythematosus |
Q93695443 | Studies of heat precipitable immunoglobulins |
Q71788034 | Studies on a crystalline myeloma protein |
Q34677678 | Symptomatic cryoglobulinemia |
Q68790093 | Systemic embolism from mitral valve vegetation in scleroderma |
Q70529823 | Systemic immune complex disease following intestinal bypass surgery: bypass disease |
Q43858585 | Systemic sclerosis and cryoglobulinemia |
Q40457866 | The Aetiology of Mixed Cryoglobulinaemia Associated with Hepatitis C Virus Infection |
Q40001885 | The Immunologic Basis of Human Renal Disease |
Q39967366 | The complement system in cryoglobulinaemia. Interaction with immunoglobulins and lipoproteins |
Q72762543 | The effect of human IgM rheumatoid factor on renal glomerular immune complex deposition in passive serum sickness in the mouse |
Q41574278 | The etiology and pathophysiology of mixed cryoglobulinemia secondary to hepatitis C virus infection |
Q30251847 | The expanding spectrum of HCV-related cryoglobulinemic vasculitis: a narrative review. |
Q38052844 | The hepatitis C virus infection as a systemic disease |
Q39484856 | The kidney in mixed cryoglobulinemias |
Q70558115 | The value of renal biopsy |
Q87873268 | Therapeutic plasma exchange for hyperviscosity syndrome secondary to high rheumatoid factor |
Q39343958 | Treatment of hepatitis C cryoglobulinemia: mission and challenges |
Q67821550 | Two different Fcγ receptor-dependent cytotoxic mechanisms triggered by monoclonal immunoglobulins |
Q70683860 | Ultrastructural "fingerprint" in cryoprecipitate and glomerular deposits: a case report of systemic lupus erythematosus |
Q47944463 | Ultrastructural changes in acute nonstreptococcal glomerulonephritis associated with mixed cryoglobulinemia |
Q36077175 | Ultrastructure in glomerulonephritis associated with cryoglobulinemia. A report of six cases and review of the literature |
Q67262122 | Use of Immunoelectrophoresis and Immunodiffusion in Clinical Medicine |
Q36051956 | Variable patterns of immunoglobulin and complement deposition in the kidneys of patients with systemic lupus erythematosus |
Q51570715 | Vasculitic multiplex mononeuritis: polyarteritis nodosa versus cryoglobulinemic vasculitis. |
Q41366423 | Vasculitic purpura in vinyl chloride disease: a case report |
Q30238653 | Vasculitic syndromes in hepatitis C virus: A review |
Q33790067 | Vasculitides secondary to systemic diseases |
Q40569779 | Vasculitides: Classification and Pathogenesis* |
Q39701514 | Vasculitis and ulceration in rheumatic diseases of the foot |
Q40089640 | Vasculitis in primary vasculitides, granulomatoses, and connective tissue diseases |
Q33621208 | Vasculitis with renal involvement in essential mixed cryoglobulinemia: Case report and mini-review |
Q38298448 | Virus-driven autoimmunity and lymphoproliferation: the example of HCV infection. |
Q93810729 | Waldenström's macroglobulinaemia with anti-IgG activity: a series of five cases |
Search more.