Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity

scientific article published on 11 September 2013

Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/JM400963Y
P698PubMed publication ID23968485

P2093author name stringDaniel Bur
Daniel Ritz
Peter Seiler
Christopher Kohl
Jean-Philippe Surivet
Marina Dos Santos
Azely Mirre
Christian Hubschwerlen
Cornelia Zumbrunn
Georg Rueedi
Jean-Christophe Gauvin
Michel Enderlin-Paput
Thierry Bruyère
Hans Locher
Wolfgang Keck
Jonathan Delers
Mika Gaertner
Verena Kaegi
Maria Boehme
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)7396-7415
P577publication date2013-09-11
P1433published inJournal of Medicinal ChemistryQ900316
P1476titleDesign, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity
P478volume56

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cites work (P2860)
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Q40356984Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an Inhibitor
Q36933417In Vivo Pharmacodynamic Target Investigation of Two Bacterial Topoisomerase Inhibitors, ACT-387042 and ACT-292706, in the Neutropenic Murine Thigh Model against Streptococcus pneumoniae and Staphylococcus aureus.
Q40833065Insights into the mechanism of inhibition of novel bacterial topoisomerase inhibitors from characterization of resistant mutants of Staphylococcus aureus
Q41108428Left-Hand Side Exploration of Novel Bacterial Topoisomerase Inhibitors to Improve Selectivity against hERG Binding
Q64085348Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase
Q37713025NBTI 5463 is a novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy
Q27644560Oxabicyclooctane-Linked Novel Bacterial Topoisomerase Inhibitors as Broad Spectrum Antibacterial Agents
Q36394817Structure-based design of novel combinatorially generated NBTIs as potential DNA gyrase inhibitors against various Staphylococcus aureus mutant strains.
Q41687386Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor
Q89573603Two Decades of Successful SAR-Grounded Stories of the Novel Bacterial Topoisomerase Inhibitors (NBTIs)

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