Foundations of Immunometabolism and Implications for Metabolic Health and Disease

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Foundations of Immunometabolism and Implications for Metabolic Health and Disease is …
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P356DOI10.1016/J.IMMUNI.2017.08.009
P932PMC publication ID5627521
P698PubMed publication ID28930657

P50authorGökhan HotamışlıgilQ6033455
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
Genetic studies of body mass index yield new insights for obesity biologyQ22305005
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetesQ24309211
An endotoxin-induced serum factor that causes necrosis of tumorsQ24564406
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodiesQ24598772
Posttranscriptional control of T cell effector function by aerobic glycolysisQ24606942
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistanceQ24617743
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effectsQ24630455
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolismQ24650184
Hypoglycemic agents and potential anti-inflammatory activityQ26750414
Endoplasmic Reticulum Stress Interacts With Inflammation in Human DiseasesQ26800781
Myeloid heme oxygenase-1 haploinsufficiency reduces high fat diet-induced insulin resistance by affecting adipose macrophage infiltration in miceQ27301363
Inflammation and metabolic disordersQ27860923
Obesity is associated with macrophage accumulation in adipose tissueQ27860976
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistanceQ28131660
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IkkbetaQ28188643
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitusQ28190307
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin actionQ28199220
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistanceQ28240815
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2Q28272571
Regulation of glucose/lipid metabolism and insulin sensitivity by interleukin-4.Q54563052
Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation.Q54633337
Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance.Q55069656
Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the LiverQ57016669
Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: A double-blinded, randomized, placebo controlled studyQ57229132
Effect of tumour necrosis factor on cultured human melanoma cellsQ67358604
Tumor necrosis factor mimics the metabolic response to acute infection in healthy humansQ68025470
Studies in obese-hyperglycemic miceQ71170497
Polymorphonuclear (PMN) function after small intestinal shunt operation for morbid obesityQ71206342
Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1Q71743266
Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptakeQ72319472
Impaired immunity in obesity: suppressed but reversible lymphocyte responsivenessQ72707020
Pathological changes in adipose tissue of obese miceQ72795558
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascadeQ77795070
Insulin antagonists, insulin antibodies and insulin resistanceQ78261740
Transitory diabetic syndrome associated with meningococcic meningitisQ83229954
Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cellsQ86800846
Direct control of hepatic glucose production by interleukin-13 in mice.Q36497258
Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean miceQ36561831
Identity of tumour necrosis factor and the macrophage-secreted factor cachectinQ28286678
Expression of suppressors of cytokine signaling during liver regenerationQ28365891
Leptin regulates proinflammatory immune responsesQ28565340
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and humanQ28591078
The role of TNF-α in mice with type 1- and 2- diabetesQ28730016
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistanceQ29012156
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseasesQ29547555
Obesity induces a phenotypic switch in adipose tissue macrophage polarizationQ29547686
IKK-beta links inflammation to obesity-induced insulin resistanceQ29614285
Thioredoxin-interacting protein links oxidative stress to inflammasome activationQ29614471
Inhibition of NF-kappa B by sodium salicylate and aspirinQ29614708
Activation of a metabolic gene regulatory network downstream of mTOR complex 1Q29615179
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signalingQ29616024
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistanceQ29616026
The hormone resistin links obesity to diabetesQ29616100
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha functionQ29616104
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasisQ29616351
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugsQ29617192
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesityQ29617380
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parametersQ29617381
Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa BQ29618096
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cellsQ29618126
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaBQ29619314
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistanceQ29619774
A central role for JNK in obesity and insulin resistanceQ29619778
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generationQ29620116
Pro-resolving lipid mediators are leads for resolution physiologyQ30829097
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarizationQ30912206
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individualsQ33345339
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.Q33652731
Tumor necrosis factor-alpha and the progression of diabetes in non-obese diabetic miceQ33713257
Adipocyte inflammation is essential for healthy adipose tissue expansion and remodelingQ33838623
Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytesQ33847436
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humansQ33854029
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetesQ33892083
IGF1 Shapes Macrophage Activation in Response to Immunometabolic ChallengeQ33910916
Forearm metabolism in obesity and its response to intra-arterial insulin. Characterization of insulin resistance and evidence for adaptive hyperinsulinismQ34026153
Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.Q34031152
Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistanceQ34105654
p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.Q36635737
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophagesQ36694157
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profileQ36729660
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistanceQ36793320
p58(IPK) suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophagesQ36835610
Innate lymphoid cells in the initiation, regulation and resolution of inflammationQ36908615
IKKβ Is Essential for Adipocyte Survival and Adaptive Adipose Remodeling in ObesityQ36930771
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivityQ36931760
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesityQ36981204
Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in miceQ37031087
Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose productionQ37127299
TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice.Q37209584
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids.Q37302656
The expression of TNF alpha by human muscle. Relationship to insulin resistanceQ37352139
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activationQ37390014
Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.Q37400702
The role of interleukins in insulin resistance and type 2 diabetes mellitus.Q37462159
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosisQ37465347
Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins.Q37466109
MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesityQ37502701
Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.Q37580289
Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseasesQ37627490
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.Q37683001
Association between tumor necrosis factor-α-308G/A polymorphism and obstructive sleep apnea: a meta-analysisQ37944347
Immunometabolism of AMPK in insulin resistance and atherosclerosisQ37987722
Adaptive immunity in obesity and insulin resistanceQ38030832
Inflammation links excess fat to insulin resistance: the role of the interleukin-1 familyQ38034273
Metabolic checkpoints in activated T cellsQ38044664
Metabolism of inflammation limited by AMPK and pseudo-starvationQ38074586
Inflammasomes and metabolic diseaseQ38166027
Adipose invariant natural killer T cells.Q38199760
The immunomodulating role of exercise in metabolic diseaseQ38200360
Targeting inflammation in the treatment of type 2 diabetes: time to startQ38214020
Metabolism of stromal and immune cells in health and diseaseQ38227775
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptideQ45078360
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.Q45223782
Platelet-Derived Mitochondria Display Embryonic Stem Cell Markers and Improve Pancreatic Islet β-cell Function in Humans.Q45816606
Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages.Q46371654
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus.Q46588693
Interleukin-10 is a protective factor against diet-induced insulin resistance in liverQ46759227
Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: involvement of cAMP-PKA and MAPK pathwaysQ46913125
AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regenerationQ47818053
The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesityQ48043703
TNF and EPO: major players in the innate immune response: their discovery.Q48459998
Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.Q48630964
Increased number of islet-associated macrophages in type 2 diabetes.Q53545508
Food for Thought: Revisiting the Complexity of Food Intake.Q53554793
Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.Q54223604
Insulin Receptors in Acute Infection: A Study of Factors Conferring Insulin Resistance*Q54477060
In vivo skeletal muscle insulin resistance during E coli endotoxin shock in the dog.Q54542165
Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetesQ38292180
Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose toleranceQ38292224
METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.Q38297313
Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration.Q38297857
Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver diseaseQ38320784
Leptin deficiency enhances sensitivity to endotoxin-induced lethality.Q38329525
Antidiabetic agents: Potential anti-inflammatory activity beyond glucose controlQ38385659
Altered control of carbohydrate metabolism in endotoxemiaQ38611831
Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 DiabetesQ38690898
Macrophage and adipocyte IGF1 maintain adipose tissue homeostasis during metabolic stressesQ39035483
Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in miceQ39037277
Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosisQ39163100
Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation.Q39297825
PKC-theta knockout mice are protected from fat-induced insulin resistanceQ39989111
Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected Wistar rats from diet-induced obesity and insulin resistanceQ40002636
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.Q40701074
Blocking high-fat diet-induced obesity, insulin resistance and fatty liver by overexpression of Il-13 gene in miceQ41197445
T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 miceQ41560139
The growth factor-like effects of tumor necrosis factor-alpha. Stimulation of glucose transport activity and induction of glucose transporter and immediate early gene expression in 3T3-L1 preadipocytesQ41714428
Adipocyte-specific IKKβ signaling suppresses adipose tissue inflammation through an IL-13-dependent paracrine feedback pathwayQ41736302
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.Q41807977
A stress signaling pathway in adipose tissue regulates hepatic insulin resistanceQ41811449
Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver diseaseQ41826139
The TSC-mTOR pathway regulates macrophage polarizationQ41832120
Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2.Q41890014
Studies of insulin resistance in adipocytes induced by macrophage mediatorQ41927242
Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic SyndromeQ42108741
A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesityQ42257294
Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesisQ42287782
TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazoneQ42446456
Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose outputQ42467904
Potential Site Effects and Transgene Expression Discrepancies in Mouse Lifespan StudiesQ42593759
Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance.Q42805774
Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and phosphatidylinositol 3-kinase activityQ42807983
Lipopolysaccharide-treated RAW 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells.Q42816226
Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha.Q42825783
Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance.Q42848637
Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm musclesQ42974694
Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditureQ43062138
Tumor necrosis factor-alpha modulates human in vivo lipolysisQ43590617
Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylationQ43699235
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleQ43990155
Effect of increased free fatty acid supply on glucose metabolism and skeletal muscle glycogen synthase activity in normal manQ44026790
Neutralization of tumor necrosis factor reverses age-induced impairment of insulin responsiveness in skeletal muscle of Sprague-Dawley ratsQ44081485
Tumors secreting human TNF/cachectin induce cachexia in miceQ44211776
Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesityQ44453978
Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acidsQ44514690
Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammationQ44633355
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivoQ44816750
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissueQ34162171
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipaseQ34216687
Identification of an adipogenic niche for adipose tissue remodeling and restorationQ34289690
Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophagesQ34316035
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in miceQ34327061
A decade of progress in adipose tissue macrophage biologyQ34372560
Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway.Q34436367
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.Q34442874
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivityQ34450240
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjectsQ34538317
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistanceQ34543004
Inflammation, metaflammation and immunometabolic disordersQ34550852
Effects of nonesterified fatty acid availability on tissue-specific glucose utilization in rats in vivoQ34557980
Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemiaQ34569886
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistanceQ34708975
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic isletsQ34796756
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2Q34804981
Activated type 2 innate lymphoid cells regulate beige fat biogenesisQ34979492
Normalization of obesity-associated insulin resistance through immunotherapyQ34994222
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesityQ35095489
New genetic loci link adipose and insulin biology to body fat distributionQ35114362
Inflammation and ER stress regulate branched-chain amino acid uptake and metabolism in adipocytesQ35140256
TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activationQ35173133
Inflammasome is a central player in the induction of obesity and insulin resistanceQ35216914
Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansionQ35220578
Tumor necrosis factor alpha inhibits signaling from the insulin receptorQ35304189
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesityQ35578618
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesityQ35660131
Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue ExpansionQ35860833
Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesityQ35922180
Macrophage-mediated inflammation in metabolic diseaseQ36060408
Meta-analysis on the G-308A tumor necrosis factor alpha gene variant and phenotypes associated with the metabolic syndrome.Q36371882
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastaseQ36377312
Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathwaysQ36385717
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)406-420
P577publication date2017-09-01
P1433published inImmunityQ6005457
P1476titleFoundations of Immunometabolism and Implications for Metabolic Health and Disease
P478volume47

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