| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M401844200 |
| P698 | PubMed publication ID | 15078873 |
| P50 | author | Carlo Tacchetti | Q56670600 |
| Marco Giorgio | Q67521799 | ||
| Luisa Lanfrancone | Q73107940 | ||
| Monica G Ferrini | Q91641278 | ||
| P2093 | author name string | Pier Giuseppe Pelicci | |
| Veronica A Raker | |||
| Ines Martin-Padura | |||
| Claudia Puri | |||
| Ildo Nicoletti | |||
| Roberta Mannucci | |||
| Maria Bono | |||
| Francesca Orsini | |||
| Maurizio Moroni | |||
| Enrica Migliaccio | |||
| Mirella Trinei | |||
| Cristina Contursi | |||
| Giovanni Pelliccia | |||
| Daniele Piccini | |||
| P433 | issue | 24 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | lifetime | Q22675021 |
| mitochondrion | Q39572 | ||
| P304 | page(s) | 25689-25695 | |
| P577 | publication date | 2004-04-12 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential | |
| P478 | volume | 279 |
| Q29547303 | A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine |
| Q37323041 | A novel role of Shc adaptor proteins in steroid hormone-regulated cancers. |
| Q36535153 | Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc |
| Q80135384 | Ageing: mice and mitochondria |
| Q36569112 | An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations |
| Q36257989 | Annual fishes of the genus Nothobranchius as a model system for aging research |
| Q54321477 | Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury. |
| Q37806845 | Cell death: Insights into the ultrastructure of mitochondria |
| Q28507649 | Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein |
| Q36936592 | Chronic nicotine exposure augments renal oxidative stress and injury through transcriptional activation of p66shc |
| Q46473480 | Coenzyme Q10 protects renal proximal tubule cells against nicotine-induced apoptosis through induction of p66shc-dependent antioxidant responses |
| Q38749097 | Construction of p66Shc gene interfering lentivirus vectors and its effects on alveolar epithelial cells apoptosis induced by hyperoxia |
| Q47391605 | Current Understanding of the TCTP Interactome |
| Q33896926 | Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration |
| Q35001796 | Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery |
| Q38292320 | Cysteine-mediated redox signalling in the mitochondria. |
| Q33352540 | Cytochrome c signalosome in mitochondria |
| Q35659007 | D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc |
| Q34078928 | Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene |
| Q33627882 | Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS) |
| Q28572126 | Distinct signaling functions for Shc isoforms in the heart |
| Q28566249 | Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning |
| Q33692629 | Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans |
| Q40371697 | Expression of p66(Shc) protein correlates with proliferation of human prostate cancer cells. |
| Q33919335 | Extracellular vesicles released from mesenchymal stromal cells modulate miRNA in renal tubular cells and inhibit ATP depletion injury |
| Q35691127 | Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress. |
| Q35757295 | Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis. |
| Q35652110 | HIV gene expression deactivates redox-sensitive stress response program in mouse tubular cells both in vitro and in vivo. |
| Q38358175 | Hitting the Bull's-Eye in Metastatic Cancers-NSAIDs Elevate ROS in Mitochondria, Inducing Malignant Cell Death. |
| Q27003901 | Hormesis in aging and neurodegeneration-a prodigy awaiting dissection |
| Q34132479 | Hyperglycemia-induced p66shc inhibits insulin-like growth factor I-dependent cell survival via impairment of Src kinase-mediated phosphoinositide-3 kinase/AKT activation in vascular smooth muscle cells |
| Q46502339 | Hyperoxia and thyroxine treatment and the relationships between reactive oxygen species generation, mitochondrial membrane potential, and cardiolipin in human lens epithelial cell cultures |
| Q37409955 | IGF-IR in neuroprotection and brain tumors |
| Q37855570 | IP(3) Receptors, Mitochondria, and Ca Signaling: Implications for Aging |
| Q46294733 | IR- Role of adaptor protein p66Shc in renal pathologies |
| Q33588657 | Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc |
| Q34500344 | Increased p66Shc in the inner ear of D-galactose-induced aging mice with accumulation of mitochondrial DNA 3873-bp deletion: p66Shc and mtDNA damage in the inner ear during aging |
| Q37100138 | Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis |
| Q47164766 | Insights into the Shc Family of Adaptor Proteins. |
| Q33865202 | Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination |
| Q28299525 | Involvement of mortalin in cellular senescence from the perspective of its mitochondrial import, chaperone, and oxidative stress management functions |
| Q35113412 | Ischemia/reperfusion injury and cardioprotective mechanisms: Role of mitochondria and reactive oxygen species |
| Q28386539 | Isolating the segment of the mitochondrial electron transport chain responsible for mitochondrial damage during cardiac ischemia |
| Q33919575 | Kinetic and structural characterization of human mortalin |
| Q36766862 | Longevity in mice: is stress resistance a common factor? |
| Q36239686 | Metabolic regulation of oxygen and redox homeostasis by p53: lessons from evolutionary biology? |
| Q36827897 | Mitochondria and cardioprotection |
| Q37421172 | Mitochondria and vascular pathology. |
| Q36558028 | Mitochondria as therapeutic targets for cancer chemotherapy |
| Q51737103 | Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics. |
| Q28394689 | Mitochondria-ros crosstalk in the control of cell death and aging |
| Q37907474 | Mitochondrial calcium homeostasis as potential target for mitochondrial medicine |
| Q92132339 | Mitochondrial dysfunction and oxidative stress in heart disease |
| Q34767374 | Mitochondrial longevity pathways |
| Q37438966 | Mitochondrial protein phosphorylation: instigator or target of lipotoxicity? |
| Q33913079 | Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release |
| Q37419562 | Mitochondrial redox signaling by p66Shc is involved in regulating androgenic growth stimulation of human prostate cancer cells. |
| Q38395524 | Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri |
| Q64107680 | Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66 |
| Q34567458 | Molecular bases of progeroid syndromes. |
| Q24632770 | Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury |
| Q33723676 | Monoamine oxidases as sources of oxidants in the heart |
| Q38223671 | Mortalin, apoptosis, and neurodegeneration |
| Q37377087 | Muscle mitohormesis promotes longevity via systemic repression of insulin signaling |
| Q28072348 | NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? |
| Q46593121 | Nicotine Enhances High-Fat Diet-Induced Oxidative Stress in the Kidney |
| Q36494428 | Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney |
| Q34703664 | On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60. |
| Q37643674 | Orchestrating redox signaling networks through regulatory cysteine switches |
| Q39349571 | Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. |
| Q33888931 | Oxidative stress causes reversible changes in mitochondrial permeability and structure |
| Q38121750 | Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging |
| Q64077558 | P66Shc and vascular endothelial function |
| Q33588755 | P66Shc signals to age. |
| Q39625856 | P66Shc, a key regulator of metabolism and mitochondrial ROS production, is dysregulated by mouse embryo culture |
| Q38760873 | Parathyroid Hormone-Related Protein Protects Osteoblastic Cells From Oxidative Stress by Activation of MKP1 Phosphatase |
| Q36835046 | Permanent embryo arrest: molecular and cellular concepts |
| Q39636299 | Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity |
| Q33888850 | Pro-apoptotic Effect of Pifithrin-α on Preimplantation Porcine In vitro Fertilized Embryo Development. |
| Q46829144 | Prolonged swimming promotes cellular oxidative stress and p66Shc phosphorylation, but does not induce oxidative stress in mitochondria in the rat heart. |
| Q35117918 | Prooxidant properties of p66shc are mediated by mitochondria in human cells |
| Q28388989 | Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling |
| Q42412082 | Reactive oxygen species and age-related genes p66shc, Sirtuin, FOX03 and Klotho in senescence |
| Q34273059 | Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells |
| Q51766595 | Redox crosstalk at endoplasmic reticulum (ER) membrane contact sites (MCS) uses toxic waste to deliver messages. |
| Q35220373 | Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells |
| Q36642761 | Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc. |
| Q37084922 | Renal ageing: changes in the cellular mechanism of energy metabolism and oxidant handling |
| Q39103238 | Role of p66shc in renal toxicity of oleic acid |
| Q39980519 | Role of the life span determinant P66(shcA) in ethanol-induced liver damage. |
| Q37763723 | Roles of mitochondria in human disease |
| Q39061148 | SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres |
| Q35806705 | Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR. |
| Q24629563 | Single-gene mutations and healthy ageing in mammals |
| Q41858985 | Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction |
| Q50507154 | Specific training improves skeletal muscle mitochondrial calcium homeostasis after eccentric exercise. |
| Q46280809 | Subcellular Redox Signaling |
| Q37136773 | Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III. |
| Q34322396 | The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging |
| Q36898560 | The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration. |
| Q38014850 | The Role of p66shc in Oxidative Stress and Apoptosis |
| Q37651334 | The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis |
| Q42256040 | The impact of resveratrol and hydrogen peroxide on muscle cell plasticity shows a dose-dependent interaction |
| Q42490911 | The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism |
| Q33307804 | The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro |
| Q57246722 | The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II |
| Q37198165 | The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death |
| Q61855832 | Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis |
| Q33613299 | Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc. |
| Q23919656 | Transcriptional responses to oxidative stress: pathological and toxicological implications |
| Q35151322 | p53, Oxidative Stress, and Aging |
| Q58454317 | p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis |
| Q28084081 | p66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosis |
| Q33793988 | p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells |
| Q40261518 | p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes |
| Q38839763 | p66Shc signaling is involved in stress responses elicited by anthracycline treatment of rat cardiomyoblasts. |
| Q37867129 | p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress |
| Q37072296 | p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria |
| Q34015848 | p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis. |
| Q92666396 | p66ShcA functions as a contextual promoter of breast cancer metastasis |
| Q34298024 | p66ShcA promotes breast cancer plasticity by inducing an epithelial-to-mesenchymal transition |
| Q33747925 | p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation |
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