Cysteine-rich protein 61 (CCN1) mediates replicative senescence-associated aberrant collagen homeostasis in human skin fibroblasts

scientific article

Cysteine-rich protein 61 (CCN1) mediates replicative senescence-associated aberrant collagen homeostasis in human skin fibroblasts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCB.24179
P698PubMed publication ID22566095

P2093author name stringJohn J Voorhees
Gary J Fisher
Taihao Quan
Zhaoping Qin
P2860cites workUltraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblastsQ42471345
Transforming growth factor beta inhibitory element in the rabbit matrix metalloproteinase-1 (collagenase-1) gene functions as a repressor of constitutive transcriptionQ42483971
'Senescence-associated' beta-galactosidase activity in the upper gastrointestinal tract.Q42519468
Integrin-mediated cell adhesion to type I collagen fibrilsQ44897864
Oxidative stress induces senescence in human mesenchymal stem cells.Q54384642
alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cellsQ24291604
CYR61 (CCN1) is essential for placental development and vascular integrityQ24540206
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
Functions and mechanisms of action of CCN matricellular proteinsQ24642303
All in the CCN family: essential matricellular signaling modulators emerge from the bunkerQ28275856
The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1Q28504860
Looking older: fibroblast collapse and therapeutic implicationsQ33336032
The CCN family of angiogenic regulators: the integrin connectionQ33545691
The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblastsQ33928429
Skin aging and menopause : implications for treatmentQ34199285
Pathophysiology of premature skin aging induced by ultraviolet lightQ34445097
Mechanisms of photoaging and chronological skin agingQ34529107
Retinoids suppress cysteine-rich protein 61 (CCN1), a negative regulator of collagen homeostasis, in skin equivalent cultures and aged human skin in vivoQ35061795
Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signalingQ35103121
Cancer and ageing: rival demons?Q35118727
CCN1 contributes to skin connective tissue aging by inducing age-associated secretory phenotype in human skin dermal fibroblastsQ35134597
The CCN family: a new stimulus packageQ35194555
Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skinQ35221977
CCN proteins: multifunctional signalling regulatorsQ35629272
Replicative senescence: a critical review.Q35947932
Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesionQ36557691
Vascular tube formation on matrix metalloproteinase-1-damaged collagenQ36667461
Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skinQ37073774
c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acidQ37267575
Matrix-degrading metalloproteinases in photoagingQ37579014
Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation.Q38623557
Matrix metalloproteinase gene expressionQ40642356
Epidemiology of nonmelanoma skin cancer: clinical issues, definitions, and classificationQ40658470
Ultraviolet irradiation blocks cellular responses to transforming growth factor-beta by down-regulating its type-II receptor and inducing Smad7.Q40810155
Integrin alpha 2 beta 1 is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen I fibrilsQ41653661
Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblastsQ41955517
Epidermal growth factor-induced hydrolysis of phosphatidylcholine by phospholipase D and phospholipase C in human dermal fibroblastsQ42076641
P433issue9
P304page(s)3011-3018
P577publication date2012-09-01
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleCysteine-rich protein 61 (CCN1) mediates replicative senescence-associated aberrant collagen homeostasis in human skin fibroblasts
P478volume113

Reverse relations

cites work (P2860)
Q35080591Age-associated reduction of cellular spreading/mechanical force up-regulates matrix metalloproteinase-1 expression and collagen fibril fragmentation via c-Jun/AP-1 in human dermal fibroblasts
Q36280202Age-related reduction of dermal fibroblast size up-regulates multiple matrix metalloproteinases as observed in aged human skin in vivo
Q89819234CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis
Q59792823Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy
Q50222696Characterization of long-term in vitro culture-related alterations of human tonsil-derived mesenchymal stem cells: role for CCN1 in replicative senescence-associated increase in osteogenic differentiation
Q36796980Cysteine-rich protein 61 (CCN1) domain-specific stimulation of matrix metalloproteinase-1 expression through αVβ3 integrin in human skin fibroblasts
Q90663139Diet and Skin Aging-From the Perspective of Food Nutrition
Q41126873Differential senescence in feto-maternal tissues during mouse pregnancy
Q33804598Diffuse colonies of human skin fibroblasts in relation to cellular senescence and proliferation.
Q37471141Elevated cysteine-rich protein 61 (CCN1) promotes skin aging via upregulation of IL-1β in chronically sun-exposed human skin
Q92237931Environmental Stressors on Skin Aging. Mechanistic Insights
Q60958004Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases
Q51400423Expression of CCN Genes and Proteins in Human Skin: Methods and Protocols.
Q49892697Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging
Q47189137Ezrin regulates skin fibroblast size/mechanical properties and YAP-dependent proliferation
Q46133557Mild mitochondrial uncoupling prevents premature senescence in human dermal fibroblasts
Q35533275Oxidant exposure induces cysteine-rich protein 61 (CCN1) via c-Jun/AP-1 to reduce collagen expression in human dermal fibroblasts
Q46487236Paracrine anti-fibrotic effects of neonatal cells and living cell constructs on young and senescent human dermal fibroblasts
Q26743421Redox mechanisms in age-related lung fibrosis
Q35915835Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review
Q41431177Standardized Kaempferia parviflora Extract Inhibits Intrinsic Aging Process in Human Dermal Fibroblasts and Hairless Mice by Inhibiting Cellular Senescence and Mitochondrial Dysfunction.
Q39171928The matricellular protein CCN1 suppresses lung cancer cell growth by inducing senescence via the p53/p21 pathway

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