Synthesis of the protein phosphatase 2A inhibitor (4S,5S,6S,10S,11S,12S)-cytostatin

scientific article published in May 2002

Synthesis of the protein phosphatase 2A inhibitor (4S,5S,6S,10S,11S,12S)-cytostatin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/1521-3773(20020517)41:10<1748::AID-ANIE1748>3.0.CO;2-X
P698PubMed publication ID19750704

P50authorHerbert WaldmannQ1609256
P2093author name stringLaurent Bialy
P2860cites workSignaling--2000 and beyondQ29617413
Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.Q30665579
Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitorsQ30876040
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Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activitiesQ48796464
Differential induction of apoptosis in B16 melanoma and EL-4 lymphoma cells by cytostatin and bactobolin.Q51091029
Total Synthesis of Fostriecin (CI-920) We thank Professor Andrew G. Myers and Scott E. Schaus for helpful discussions, and Dr. Alexandra E. Gould and Isabel K. Reichardt for important preliminary experimental work. We also thank Dr. Robert J. SchultQ52128778
Highly enantioselective borane reduction of ketones catalyzed by chiral oxazaborolidines. Mechanism and synthetic implicationsQ55968086
Enantioselective aldol condensations. 2. Erythro-selective chiral aldol condensations via boron enolatesQ56288437
The total synthesis of the polyether antibiotic X-206Q56288438
Novel antitumor agents CI-920, PD 113 270, and PD 113 271. 3. Structure determinationQ56813253
Direct synthesis of Z-unsaturated esters. A useful modification of the horner-emmons olefinationQ57973769
A useful 12-I-5 triacetoxyperiodinane (the Dess-Martin periodinane) for the selective oxidation of primary or secondary alcohols and a variety of related 12-I-5 speciesQ60450980
Novel microbial metabolites of the phoslactomycins family induce production of colony-stimulating factors by bone marrow stromal cells. II. Isolation, physico-chemical properties and structure determinationQ71599514
Inhibitory effect of cytostatin on spontaneous lung metastases of B16-BL6 melanoma cellsQ71921018
Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. II. Physico-chemical properties and structure determinationQ72081242
Dysidiolide and related gamma-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25Q73022439
Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2AQ73176678
Synthesis of the novel analogues of dysidiolide and their structure-activity relationshipQ73211150
Asymmetric Reduction. A Convenient Method for the Reduction of Alkynyl KetonesQ74823060
Highly Enantioenriched Propargylic Alcohols by Oxazaborolidine-Mediated Reduction of Acetylenic KetonesQ74825047
P433issue10
P304page(s)1748-1751
P577publication date2002-05-01
P1433published inAngewandte ChemieQ538683
P1476titleSynthesis of the protein phosphatase 2A inhibitor (4S,5S,6S,10S,11S,12S)-cytostatin
P478volume41

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cites work (P2860)
Q43096915Good timing in total synthesis: the case of phoslactomycin A.
Q44581041SuperQuat N-acyl-5,5-dimethyloxazolidin-2-ones for the asymmetric synthesis of alpha-alkyl and beta-alkyl aldehydes.
Q47813033Synthesis of a Bioreversibly Masked Lipophilic Adenosine Diphosphate Ribose Derivative
Q39058997Synthetic Strategies Employed for the Construction of Fostriecin and Related Natural Products
Q45130673The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors
Q34300129Total Synthesis and Evaluation of Phostriecin and Key Structural Analogues
Q30484031Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition
Q33665560Total synthesis, assignment of the relative and absolute stereochemistry, and structural reassignment of phostriecin (aka Sultriecin)

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