C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways

scientific article

C/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M001286200
P698PubMed publication ID10906322

P50authorValeria PoliQ35703792
Karen ChapmanQ38524444
P2093author name stringSeckl JR
Darlington GJ
MacLeod I
Lyons V
Williams LJ
Rajan V
P2860cites workCloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2Q24534167
Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptorQ24561876
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzymeQ28115363
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediatedQ28281477
A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitroQ28296697
Firefly luciferase gene: structure and expression in mammalian cellsQ29616519
Alkylation interference identifies essential DNA contacts for sequence-specific binding of the eukaryotic transcription factor C/EBPQ33596869
Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2.Q33843488
Is CCAAT/enhancer-binding protein a central regulator of energy metabolism?Q34661217
Impaired Energy Homeostasis in C/EBPα Knockout MiceQ34662358
Biological role of the CCAAT/enhancer-binding protein family of transcription factorsQ34663643
Cloning and characterisation of the abundant cytoplasmic 7S RNA from mouse cellsQ35521899
Glucocorticoid-stimulated CCAAT/enhancer-binding protein alpha expression is required for steroid-induced G1 cell cycle arrest of minimal-deviation rat hepatoma cellsQ36562528
'Liver-type' 11 beta-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells.Q36714987
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stressQ36833926
Identification of an estrogen-responsive element from the 5'-flanking region of the rat prolactin geneQ36924882
CAAT/enhancer binding protein is able to bind to ATF/CRE elementsQ40532197
C/EBP alpha: a critical regulator of genes governing integrative metabolic processesQ41005354
11Beta-hydroxysteroid dehydrogenase 1 in adipocytes: expression is differentiation-dependent and hormonally regulatedQ41036334
11 beta-hydroxysteroid dehydrogenase type 1 expression in 2S FAZA hepatoma cells is hormonally regulated: a model system for the study of hepatic glucocorticoid metabolismQ41184548
The DNA binding domain of the rat liver nuclear protein C/EBP is bipartiteQ41260447
Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesisQ41283113
Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoidsQ41283123
Tissue-specific modulation of glucocorticoid action by the 11 beta-hydroxysteroid dehydrogenasesQ41505391
Medical and physiological aspects of the 11beta-hydroxysteroid dehydrogenase systemQ41643612
Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activationQ41673139
Tissue- and temporal-specific regulation of 11beta-hydroxysteroid dehydrogenase type 1 by glucocorticoids in vivoQ48154643
Interactions between oestradiol and glucocorticoid regulatory effects on liver-specific glucocorticoid-inducible genes: possible evidence for a role of hepatic 11beta-hydroxysteroid dehydrogenase type 1.Q48328332
Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth.Q52192519
The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity FunctionsQ57272895
P433issue39
P407language of work or nameEnglishQ1860
P921main subjecthydroxysteroidQ2157080
P304page(s)30232-30239
P577publication date2000-09-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleC/EBP regulates hepatic transcription of 11beta -hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C/EBP and glucocorticoid signaling pathways
P478volume275

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cites work (P2860)
Q3698250911beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function
Q3559911411beta-Hydroxysteroid dehydrogenase Type 1 in obesity and Type 2 diabetes
Q3520779411beta-hydroxysteroid dehydrogenases, cell proliferation and malignancy
Q3514416811β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress
Q3765588411β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action
Q90164408A heretical view: rather than a solely placental protective function, placental 11β hydroxysteroid dehydrogenase 2 also provides substrate for fetal peripheral cortisol synthesis in obese pregnant ewes
Q50478905A post-weaning fish oil dietary intervention reverses adverse metabolic outcomes and 11β-hydroxysteroid dehydrogenase type 1 expression in postnatal overfed rats.
Q34169832A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease
Q34467039Adipogenesis: forces that tip the scales.
Q34033578C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis
Q34221912Central glucocorticoid administration promotes weight gain and increased 11β-hydroxysteroid dehydrogenase type 1 expression in white adipose tissue
Q52876295Changes in gluconeogenesis and intracellular lipid accumulation characterize uremic human hepatocytes ex vivo.
Q38084054Changing glucocorticoid action: 11β-hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation.
Q37990943Corticosteroid-induced osteoporosis: an update for dermatologists
Q28573234DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins
Q42820080Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue
Q34222762Dietary fatty acid composition alters 11β-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue
Q42991443Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation
Q42830784Differential modulation of 3T3-L1 adipogenesis mediated by 11beta-hydroxysteroid dehydrogenase-1 levels
Q45005939Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis.
Q53882426Effects of leptin and dexamethasone on long and short leptin receptor mRNA.
Q52641727Enhanced hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to diet-induced visceral adiposity.
Q35578270Enzymology and Molecular Biology of Glucocorticoid Metabolism in Humans
Q41959238Evidence for transcript-specific epigenetic regulation of glucocorticoid-stimulated skeletal muscle 11β-hydroxysteroid dehydrogenase-1 activity in type 2 diabetes
Q42808708Fructose promotes the differentiation of 3T3-L1 adipocytes and accelerates lipid metabolism.
Q35937728G6PT-H6PDH-11βHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syndrome.
Q39962795Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT/enhancer-binding protein-beta
Q37062092Glucocorticoid-induced osteoporosis: clinical and therapeutic aspects
Q36848804Glucocorticoid-induced osteoporosis: pathophysiology and therapy
Q37146798Increased glycogen synthase kinase-3β and hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to glucocorticoid-induced mouse visceral adiposity
Q28235230Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity
Q35227088Insulin, CCAAT/enhancer-binding proteins and lactate regulate the human 11β-hydroxysteroid dehydrogenase type 2 gene expression in colon cancer cell lines
Q34071494Neonatal overfeeding induced by small litter rearing causes altered glucocorticoid metabolism in rats
Q35006048Pro-inflammatory cytokine induction of 11β-hydroxysteroid dehydrogenase type 1 in A549 cells requires phosphorylation of C/EBPβ at Thr235
Q55058115Programming for increased expression of hippocampal GAD67 mediated the hypersensitivity of the hypothalamic-pituitary-adrenal axis in male offspring rats with prenatal ethanol exposure.
Q41259479Reciprocal regulation of 11β-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor expression by dexamethasone inhibits human coronary artery smooth muscle cell proliferation in vitro
Q35107284Regulation of 11β-hydroxysteroid dehydrogenase type 1 and 7α-hydroxylase CYP7B1 during social stress
Q34291446Regulation of adipocyte 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by CCAAT/enhancer-binding protein (C/EBP) β isoforms, LIP and LAP.
Q34628676Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis
Q36543249Sex-Dependent effects of developmental arsenic exposure on methylation capacity and methylation regulation of the glucocorticoid receptor system in the embryonic mouse brain
Q36720586Sexually dimorphic effects of maternal nutrient reduction on expression of genes regulating cortisol metabolism in fetal baboon adipose and liver tissues.
Q51925043Stimulation of 11β-HSD1 expression by IL-1β via a C/EBP binding site in human fetal lung fibroblasts.
Q37190220Th2 cytokine-induced upregulation of 11beta-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of proasthmatic airway smooth muscle function
Q37732574The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights
Q24657968The biological actions of dehydroepiandrosterone involves multiple receptors
Q37629023Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice
Q39904526Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells
Q35902915Ubiquitin-specific protease 2 regulates hepatic gluconeogenesis and diurnal glucose metabolism through 11β-hydroxysteroid dehydrogenase 1
Q35123910Vitamin A decreases pre-receptor amplification of glucocorticoids in obesity: study on the effect of vitamin A on 11beta-hydroxysteroid dehydrogenase type 1 activity in liver and visceral fat of WNIN/Ob obese rats

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