Double negative Treg cells promote nonmyeloablative bone marrow chimerism by inducing T‐cell clonal deletion and suppressing NK cell function

scientific article published on May 1, 2012

Double negative Treg cells promote nonmyeloablative bone marrow chimerism by inducing T‐cell clonal deletion and suppressing NK cell function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.201141808
P953full work available online athttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Feji.201141808
https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.201141808
P698PubMed publication ID22539294

P50authorAnthony M JevnikarQ91377701
Zhu-Xu ZhangQ91377704
P2093author name stringShuang Wang
Ye Su
Wei-Ping Min
Ziqin Yin
Xuyan Huang
P2860cites workTh17 and regulatory T cells in mediating and restraining inflammationQ27687428
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Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioningQ33796796
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Immunobiology of natural killer cells and bone marrow transplantation: merging of basic and preclinical studiesQ34341485
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Coordination of early protective immunity to viral infection by regulatory T cellsQ34591024
Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cellsQ34600272
The complementary roles of deletion and regulation in transplantation toleranceQ35058547
New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses.Q35804507
Acute rejection of murine bone marrow allografts by natural killer cells and T cells. Differences in kinetics and target antigens recognizedQ36357551
Deletion of donor-reactive cells as a new conditioning regimen for allogeneic bone marrow transplantationQ36796115
Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal modelQ37174844
A unique population of extrathymically derived alpha beta TCR+CD4-CD8- T cells with regulatory functions dominates the mouse female genital tractQ37870198
Characterization of the immunoregulatory function of human TCR‐αβ+ CD4−CD8− double‐negative T cellsQ39599154
Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytesQ40530227
A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantationQ40657985
Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.Q40794187
The potential role of NK cells in the separation of graft‐versus‐tumor effects from graft‐versus‐host disease after allogeneic bone marrow transplantationQ41561731
The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo.Q42944882
Induction of permanent mixed chimerism and skin allograft tolerance across fully MHC-mismatched barriers by the additional myelosuppressive treatments in mice primed with allogeneic spleen cells followed by cyclophosphamideQ43406138
Long-term survival of intestinal allografts induced by costimulation blockade, busulfan and donor bone marrow infusion.Q44549969
Long-term mixed chimerism after immunologic conditioning and MHC-mismatched stem-cell transplantation is dependent on NK-cell toleranceQ46520818
Inhibition of graft-versus-host disease by double-negative regulatory T cellsQ47817030
NKT cells: what's in a name?Q47895830
An essential role for Fas ligand in transplantation tolerance induced by donor bone marrowQ50902987
Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursorsQ52009393
TCR/self-antigen interactions drive double-negative T cell peripheral expansion and differentiation into suppressor cellsQ52016217
Anti-NK cell treatment induces stable mixed chimerism in MHC-mismatched, T cell-depleted, nonmyeloablative bone marrow transplantationQ53877422
Requirement for T-cell apoptosis in the induction of peripheral transplantation toleranceQ54073234
Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and toleranceQ56906585
Functional double-negative T cells in the periphery express T cell receptor Vβ gene products that cause deletion of single-positive T cellsQ60532577
Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentationQ60997248
Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated miceQ71563740
Simultaneous administration of adjuvant donor bone marrow in pancreas transplant recipientsQ73010231
CD4(-)CD8(-) regulatory T cells implicated in preventing graft-versus-host and promoting graft-versus-leukemia responsesQ73669450
Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppressionQ73977252
Ly-6A is critical for the function of double negative regulatory T cellsQ74456285
Critical role of NK but not NKT cells in acute rejection of parental bone marrow cells in F1 hybrid miceQ77357383
Local irradiation enhances congenic donor pluripotent hematopoietic stem cell engraftment similarly in irradiated and nonirradiated sitesQ79236919
Hematopoietic chimerism induces renal and skin allograft tolerance in DLA-identical dogsQ79420959
Donor double-negative Treg promote allogeneic mixed chimerism and toleranceQ79829285
Mixed chimerism and transplantation toleranceQ79909395
Addition of cyclophosphamide to T-cell depletion-based nonmyeloablative conditioning allows donor T-cell engraftment and clonal deletion of alloreactive host T-cells after bone marrow transplantationQ80220241
Double-negative regulatory T cells induce allotolerance when expanded after allogeneic haematopoietic stem cell transplantationQ80816868
Adoptive transfer of double negative T regulatory cells induces B-cell death in vivo and alters rejection pattern of rat-to-mouse heart transplantationQ80852148
Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantationQ80884347
NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantationQ82322261
Adoptive transfer of DNT cells induces long-term cardiac allograft survival and augments recipient CD4+Foxp3+ Treg cell accumulationQ82442428
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1216-1225
P577publication date2012-05-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleDouble negative Treg cells promote nonmyeloablative bone marrow chimerism by inducing T-cell clonal deletion and suppressing NK cell function
Double negative Treg cells promote nonmyeloablative bone marrow chimerism by inducing T‐cell clonal deletion and suppressing NK cell function
P478volume42

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cites work (P2860)
Q50067913Correlation between pediatric donor characteristics and cell compositions in mixture allografts of combined G-CSF-mobilized PBSCs and bone marrow allografts
Q93198646DNT Cell-based Immunotherapy: Progress and Applications
Q36557519Immunoregulatory CD4(-)CD8(-) T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer
Q36537036In vivo activation of transferred regulatory T cells specific for third‐party exogenous antigen controls GVH disease in mice
Q38068541Role of pharmacogenetics in busulfan/cyclophosphamide conditioning therapy prior to hematopoietic stem cell transplantation
Q37709825T-regulatory cell treatment prevents chronic rejection of heart allografts in a murine mixed chimerism model
Q41495222The impact of donor characteristics on the immune cell composition of mixture allografts of granulocyte-colony-stimulating factor-mobilized marrow harvests and peripheral blood harvests

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