MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease

scientific article published on 12 January 2018

MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1100381838
P356DOI10.1186/S12974-018-1053-4
P932PMC publication ID5767033
P698PubMed publication ID29329581

P2093author name stringGuohui Lu
Shizhong Zhang
Xiaozheng He
Fengfei Lu
Hengxu Mao
Yongyi Ye
Longping Yao
P2860cites workMicroRNAs: target recognition and regulatory functionsQ24609584
Neuroinflammation in the pathophysiology of Parkinson's disease and therapeutic evidence of anti-inflammatory drugsQ26801035
RT-PCR-based analysis of microRNA (miR-1 and -124) expression in mouse CNSQ28279898
Identification of a unique TGF-β-dependent molecular and functional signature in microgliaQ28303557
A MicroRNA feedback circuit in midbrain dopamine neuronsQ28513149
Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3Q28594813
Microglia-mediated neurotoxicity: uncovering the molecular mechanismsQ29547835
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's diseaseQ29614900
Neuroinflammation in Parkinson's disease: a target for neuroprotection?Q29616300
Ulinastatin downregulates TLR4 and NF-kB expression and protects mouse brains against ischemia/reperfusion injuryQ48311927
Microglial P2X₇ receptor in the hypothalamic paraventricular nuclei contributes to sympathoexcitatory responses in acute myocardial infarction rat.Q48406439
The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease.Q48770351
Ligation of microglial CD40 results in p44/42 mitogen-activated protein kinase-dependent TNF-alpha production that is opposed by TGF-beta 1 and IL-10Q73242294
Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivoQ73760293
Neuroinflammation Induces NeurodegenerationQ89925183
Microglial physiology: unique stimuli, specialized responsesQ29620417
MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47.Q30937357
New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesisQ33760277
Mesenchymal stem cells inhibit lipopolysaccharide-induced inflammatory responses of BV2 microglial cells through TSG-6.Q34026906
The essential role of MEKK3 in TNF-induced NF-kappaB activationQ34082436
A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesityQ34143227
MicroRNA-7 protects against 1-methyl-4-phenylpyridinium-induced cell death by targeting RelA.Q34197681
Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's diseaseQ34535020
MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway.Q34606028
Presenilin 2 influences miR146 level and activity in microgliaQ35137238
MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell DeathQ35583229
Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's diseaseQ35808960
A comparative review of cell culture systems for the study of microglial biology in Alzheimer's diseaseQ36125335
MicroRNA-124 as a novel treatment for persistent hyperalgesiaQ36161510
Testing NF-κB-based therapy in hemiparkinsonian monkeysQ36166141
Neuroplasticity, axonal guidance and micro-RNA genes are associated with morphine self-administration behaviorQ36335668
Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's diseaseQ36537780
microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease.Q36610305
Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson diseaseQ36659955
Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synucleinQ36718966
MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokinesQ37279851
MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3.Q37609283
Extracellular α--synuclein-a novel and crucial factor in Lewy body diseases.Q38182337
Differential Roles of M1 and M2 Microglia in Neurodegenerative DiseasesQ38322767
MiR-124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim.Q38874732
The role of microRNA in neuronal inflammation and survival in the post ischemic brain: a reviewQ39334671
Parthenolide inhibits the LPS-induced secretion of IL-6 and TNF-α and NF-κB nuclear translocation in BV-2 microgliaQ39391666
MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascadesQ39563020
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.Q40074115
Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cellsQ40344505
Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model.Q42941982
Neurological disorders: microRNA gets motoringQ43592120
The activation of μ-opioid receptor potentiates LPS-induced NF-kB promoting an inflammatory phenotype in microgliaQ44338722
Downregulation of miR-124 in MPTP-treated mouse model of Parkinson's disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins.Q46898533
Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes.Q47191620
MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's diseaseQ47423116
The pro-differentiating role of miR-124: indicating the road to become a neuronQ48176430
P433issue1
P921main subjectParkinson's diseaseQ11085
microRNAQ310899
P304page(s)13
P577publication date2018-01-12
P1433published inJournal of NeuroinflammationQ15716679
P1476titleMicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease
P478volume15

Reverse relations

cites work (P2860)
Q88938163Decreased MiR-128-3p alleviates the progression of rheumatoid arthritis by up-regulating the expression of TNFAIP3
Q93197671Downregulated lncRNA-SNHG1 enhances autophagy and prevents cell death through the miR-221/222 /p27/mTOR pathway in Parkinson's disease
Q98771666Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia
Q91693416Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases
Q89494159MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders
Q92850322Protodioscin protects PC12 cells against oxygen and glucose deprivation-induced injury through miR-124/AKT/Nrf2 pathway
Q91580885TRAF6-p38/JNK-ATF2 axis promotes microglial inflammatory activation
Q90461848The MicroRNA Centrism in the Orchestration of Neuroinflammation in Neurodegenerative Diseases
Q92257585The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury
Q92431578miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease
Q61810937miR‑505 inhibits cell growth and EMT by targeting MAP3K3 through the AKT‑NFκB pathway in NSCLC cells

Search more.