Enoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis

scientific article published on 10 January 2018

Enoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1186/S40360-017-0184-Z
P932PMC publication ID5763526
P698PubMed publication ID29321061

P2093author name stringNajah Hadi
Hayder Chasib Assad
Reem Ali Shaker
Samer Hassan Abboud
P2860cites workThe Role of Biomarkers in Decreasing Risk of Cardiac Toxicity after Cancer TherapyQ26743433
The anthracyclines: will we ever find a better doxorubicin?Q28184842
Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicityQ29614981
Mechanisms of Anthracycline Cardiotoxicity and Strategies to Decrease Cardiac DamageQ30439608
Therapeutic use of heparin beyond anticoagulationQ33387579
Pharmacological and clinical differences between low-molecular-weight heparins: implications for prescribing practice and therapeutic interchange.Q33685447
Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicityQ34203187
Extracellular superoxide dismutase and cardiovascular diseaseQ34747179
Isorhamnetin protects against doxorubicin-induced cardiotoxicity in vivo and in vitroQ34749618
Doxorubicin pathways: pharmacodynamics and adverse effectsQ35048393
Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasomeQ35124414
Opposing effects of low molecular weight heparins on the release of inflammatory cytokines from peripheral blood mononuclear cells of asthmaticsQ35147247
Noninvasive molecular imaging of apoptosis in a mouse model of anthracycline-induced cardiotoxicityQ35260701
In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced CardiotoxicityQ35809052
Different effects of resveratrol on dose-related Doxorubicin-induced heart and liver toxicity.Q36467387
Heparin protection against Fe2+ -and Cu2+ -mediated oxidation of liposomes.Q36833327
The anti-inflammatory effects of heparin and related compoundsQ36922642
Dual effect of heparin on Fe²⁺-induced cardiolipin peroxidation: implications for peroxidation of cytochrome c oxidase bound cardiolipinQ37198499
Vitexin attenuates acute doxorubicin cardiotoxicity in rats via the suppression of oxidative stress, inflammation and apoptosis and the activation of FOXO3aQ37204101
Comparison of therapeutic effect of low-dose low-molecular-weight heparin (enoxaparin) vs. oral prednisone in treatment of patients with lichen planus; A clinical trialQ37271573
Doxorubicin: the good, the bad and the ugly effectQ37528487
Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategiesQ37998724
The role of nitric oxide in Doxorubicin-induced cardiotoxicity: experimental studyQ38914599
Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity.Q40094247
Enoxaparin reduces H2O2-induced activation of human endothelial cells by a mechanism involving cell adhesion molecules and nuclear transcription factorsQ40177846
Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino ratsQ40826943
Dasatinib May Override F317L BCR-ABL Kinase Domain Mutation in Patients with Chronic Myeloid LeukemiaQ41846360
Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolismQ42647384
Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats.Q43166156
Activation of the p38 MAPK/NF-κB pathway contributes to doxorubicin-induced inflammation and cytotoxicity in H9c2 cardiac cellsQ43586768
Doxorubicin-induced persistent oxidative stress to cardiac myocytes.Q43615200
Preventive effects of enoxaparin and hesperidin in cerulein-induced acute pancreatitis in rats.Q43706638
Medroxyprogesterone acetate, enoxaparin and pentoxyfylline cause alterations in lipid peroxidation, paraoxonase (PON1) activities and homocysteine levels in the acute oxidative stress in an experimental model of spinal cord injuryQ44181502
Erdosteine prevents doxorubicin-induced cardiotoxicity in rats.Q44539267
Protective effect of low molecular weight heparin on oxidative injury and cellular abnormalities in adriamycin-induced cardiac and hepatic toxicityQ44641679
Troponin-T and brain natriuretic peptide as predictors for adriamycin-induced cardiomyopathy in ratsQ44743568
Cardiotoxicity of doxorubicin/paclitaxel combination in rats: effect of sequence and timing of administrationQ44880187
Self-assembled betulinic acid protects doxorubicin induced apoptosis followed by reduction of ROS-TNF-α-caspase-3 activityQ46717925
Influence of a low-molecular-weight heparin derivative on the nitric oxide levels and apoptotic DNA damage in adriamycin-induced cardiac and renal toxicityQ46768547
Prospective longitudinal evaluation of doxorubicin-induced cardiomyopathy in sarcoma patients: a report of the late effects surveillance system (LESS).Q46840009
Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animalsQ46979860
Acute effect of standard heparin versus low molecular weight heparin on oxidative stress and inflammation in hemodialysis patientsQ47310363
Low-molecular weight and unfractionated heparins induce a downregulation of inflammation: decreased levels of proinflammatory cytokines and nuclear factor-kappaB in LPS-stimulated human monocytesQ47347418
The effect of low molecular weight heparin on survival in patients with advanced malignancyQ47392658
Cardiac troponin-I, brain natriuretic peptide and endothelin-1 levels in a rat model of doxorubicin-induced cardiac injuryQ48903245
Effects of enoxaparin in the rat hippocampus following traumatic brain injuryQ48931467
Effect of metformin and sitagliptin on doxorubicin-induced cardiotoxicity in adult male albino rats.Q52887129
Heparin modulates the expression of genes encoding pro and anti-apoptotic proteins in endothelial cells exposed to intestinal ischemia and reperfusion in rats.Q53032372
Effect of valsartan on cardiac senescence and apoptosis in a rat model of cardiotoxicity.Q53148765
Investigation of possible prophylactic, renoprotective, and cardioprotective effects of thromboprophylactic drugs against ischemia-reperfusion injury.Q53593146
Doxorubicin induces apoptosis by activation of caspase-3 in cultured cardiomyocytes in vitro and rat cardiac ventricles in vivo.Q53618473
Acute ischemic stroke and heparin treatmentsQ73447343
Cardioprotective effects of subcutaneous ebselen against daunorubicin-induced cardiomyopathy in ratsQ79433429
Interleukin-1 signaling mediates acute doxorubicin-induced cardiotoxicityQ82034595
Catechin protects against oxidative stress and inflammatory-mediated cardiotoxicity in adriamycin-treated ratsQ82487965
[Low molecular weight heparin inhibits cell apoptosis in the placenta of rats with preeclampsia-like symptoms]Q84378582
Factor-Xa inhibitors protect against systemic oxidant damage induced by peripheral-ischemia reperfusionQ86705822
Antioxidants and tumor necrosis factor alpha-inhibiting activity of sesame oil against doxorubicin-induced cardiotoxicityQ87124553
P433issue1
P921main subjectdoxorubicinQ18936
P304page(s)3
P577publication date2018-01-10
P1433published inBMC pharmacology & toxicologyQ27724429
P1476titleEnoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis
P478volume19