Investigational HIV integrase inhibitors in phase I and phase II clinical trials

scientific article published on 28 September 2017

Investigational HIV integrase inhibitors in phase I and phase II clinical trials is …
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scholarly articleQ13442814

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P356DOI10.1080/13543784.2017.1378643
P698PubMed publication ID28956664

P50authorMark WainbergQ3294273
Thibault MesplèdeQ40671705
P2093author name stringYingshan Han
P2860cites workResistance against Integrase Strand Transfer Inhibitors and Relevance to HIV PersistenceQ26801286
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replicationQ27661671
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A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge.Q35667426
The promise and pitfalls of long-acting injectable agents for HIV preventionQ36561375
Allosteric inhibition of HIV-1 integrase activityQ36920004
Lack of pharmacokinetic interaction between rilpivirine and integrase inhibitors dolutegravir and GSK1265744.Q37263531
Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.Q37469579
Integrase strand transfer inhibitors in the management of HIV-positive individualsQ38192022
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Cabotegravir long-acting for HIV-1 preventionQ38518446
Review of integrase strand transfer inhibitors for the treatment of human immunodeficiency virus infectionQ38570500
Targeting Virus-host Interactions of HIV ReplicationQ38577612
Switching regimens in virologically suppressed HIV-1-infected patients: evidence base and rationale for integrase strand transfer inhibitor (INSTI)-containing regimensQ38813848
Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection (GS-US-380-1489): a double-blind, multicentre, phase 3, randomised controlled non-inferiority trialQ40059801
Antiviral Activity, Safety, and Pharmacokinetics of Bictegravir as 10-Day Monotherapy in HIV-1-Infected AdultsQ40333725
Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolamQ41015337
Cabotegravir plus rilpivirine, once a day, after induction with cabotegravir plus nucleoside reverse transcriptase inhibitors in antiretroviral-naive adults with HIV-1 infection (LATTE): a randomised, phase 2b, dose-ranging trialQ41095343
The long-acting integrase inhibitor GSK744 protects macaques from repeated intravaginal SHIV challengeQ41544436
Pharmacokinetics, safety, and tolerability with repeat doses of GSK1265744 and rilpivirine (TMC278) long-acting nanosuspensions in healthy adultsQ41618857
Differential sensitivities of retroviruses to integrase strand transfer inhibitorsQ42017701
Pharmacokinetics, safety, and monotherapy antiviral activity of GSK1265744, an HIV integrase strand transfer inhibitorQ42260849
GSK1265744 pharmacokinetics in plasma and tissue after single-dose long-acting injectable administration in healthy subjectsQ42678192
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectphase I clinical trialQ5452194
phase II clinical trialQ42824440
P304page(s)1207-1213
P577publication date2017-09-28
P1433published inExpert Opinion on Investigational DrugsQ5421208
P1476titleInvestigational HIV integrase inhibitors in phase I and phase II clinical trials
P478volume26