Recombinant soluble apyrase APT102 inhibits thrombosis and intimal hyperplasia in vein grafts without adversely affecting hemostasis or re-endothelialization

scientific article published on 12 January 2017

Recombinant soluble apyrase APT102 inhibits thrombosis and intimal hyperplasia in vein grafts without adversely affecting hemostasis or re-endothelialization is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JTH.13621
P932PMC publication ID5378664
P698PubMed publication ID28079982

P2093author name stringY Ji
R Chen
W P Fay
O Adeola
T L Strawn
S S Jeong
P2860cites workThe endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.Q30448825
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Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseasesQ35089600
Contribution of endothelial injury and inflammation in early phase to vein graft failure: the causal factors impact on the development of intimal hyperplasia in murine modelsQ35179817
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Coronary vein graft disease: pathogenesis and preventionQ37215596
Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis.Q37218194
Inhibition of smooth muscle cell migration and neointima formation in vein grafts by overexpression of matrix metalloproteinase-3.Q37276960
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Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunityQ37876541
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Correlates of saphenous vein graft hyperplasia and occlusion 1 year after coronary artery bypass grafting: analysis from the CASCADE randomized trial.Q38444455
Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibitionQ39611446
The ADP antagonist MRS2179 regulates the phenotype of smooth muscle cells to limit intimal hyperplasiaQ41663331
Aortocoronary saphenous vein graft disease: pathogenesis, predisposition, and preventionQ41729196
Human Umbilical Cord Blood–Derived Endothelial Cells Reendothelialize Vein Grafts and Prevent ThrombosisQ41849182
Multifaceted role of plasminogen activator inhibitor-1 in regulating early remodeling of vein bypass graftsQ42128982
P2Y11 impairs cell proliferation by induction of cell cycle arrest and sensitizes endothelial cells to cisplatin-induced cell deathQ42742419
C-reactive protein induces expression of tissue factor and plasminogen activator inhibitor-1 and promotes fibrin accumulation in vein graftsQ42941011
Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding riskQ43102079
Extracellular nucleotides induce arterial smooth muscle cell migration via osteopontin.Q43778731
Adenosine-induced increase in graft flow during coronary bypass surgeryQ44496945
A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay.Q50896016
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Macrophage depletion alters vein graft intimal hyperplasia.Q53975070
Extracellular ATP and ADP stimulate proliferation of porcine aortic smooth muscle cellsQ67523058
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Adenosine and hypoxia stimulate proliferation and migration of endothelial cellsQ68498896
Experimental vein grafts in the rat: re-endothelialization and permeability to albuminQ71660967
Adenosine stimulates proliferation of human endothelial cells in cultureQ72860000
Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier functionQ73112984
Adenosine inhibits growth of human aortic smooth muscle cells via A2B receptorsQ74132799
CD39/vascular ATP diphosphohydrolase modulates xenograft survivalQ74146889
Purinergic receptor distribution in endothelial cells in blood vessels: a basis for selection of coronary artery graftsQ77924130
Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathwaysQ81668348
Human solCD39 inhibits injury-induced development of neointimal hyperplasiaQ82300172
Activity and expression of ecto-5'-nucleotidase/CD73 are increased by thyroid hormones in vascular smooth muscle cellsQ83827471
P433issue4
P921main subjectthrombosisQ261327
P304page(s)814-825
P577publication date2017-02-23
P1433published inJournal of Thrombosis and HaemostasisQ6296004
P1476titleRecombinant soluble apyrase APT102 inhibits thrombosis and intimal hyperplasia in vein grafts without adversely affecting hemostasis or re-endothelialization
P478volume15

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