Interleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension

scientific article published in September 2017

Interleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.HEALUN.2017.08.011
P8608Fatcat IDrelease_5oz52s2gzze4fm44qp2js5hwc4
P932PMC publication ID5854490
P698PubMed publication ID28893516

P50authorThenappan ThenappanQ50973961
Kurt W PrinsQ83420087
P2093author name stringStephen L Archer
Alok Sharma
E Kenneth Weir
Marc Pritzker
Lauren Rose
P2860cites workInterleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathwayQ28115005
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractilityQ28574235
Relationship of interleukin-6 with regional and global left-ventricular function in asymptomatic individuals without clinical cardiovascular disease: insights from the Multi-Ethnic Study of AtherosclerosisQ33764598
Inflammation and immunity in the pathogenesis of pulmonary arterial hypertensionQ33898213
Pulmonary arterial hypertension in France: results from a national registryQ33993302
Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertensionQ35021804
Echocardiographic predictors of mortality in patients with pulmonary hypertension and cardiopulmonary comorbidities.Q35182424
Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertensionQ35565086
Right heart dysfunction in heart failure with preserved ejection fractionQ35588220
Sildenafil prevents and reverses transverse-tubule remodeling and Ca(2+) handling dysfunction in right ventricle failure induced by pulmonary artery hypertension.Q35699243
Differential calcium handling in two canine models of right ventricular pressure overloadQ36198962
Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathwaysQ36681664
Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and DysfunctionQ36994116
Relationship of CRP, IL-6, and fibrinogen with right ventricular structure and function: the MESA-Right Ventricle StudyQ37248994
Pulmonary pulse wave transit time is associated with right ventricular-pulmonary artery coupling in pulmonary arterial hypertension.Q37555462
Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL).Q38372331
Enhanced pulmonary vasodilator reserve and abnormal right ventricular: pulmonary artery coupling in heart failure with preserved ejection fractionQ38413616
Interleukin-6 overexpression induces pulmonary hypertensionQ41056520
Hypoxic stress induces cardiac myocyte-derived interleukin-6.Q41363376
Leukemia Inhibitory Factor and Interleukin-6 downregulate sarcoplasmic reticulum Ca2+ ATPase (SERCA2) in cardiac myocytesQ41728755
Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat.Q42169450
Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in miceQ42273111
Tricuspid annular displacement predicts survival in pulmonary hypertensionQ44026625
Plasma interleukin-6 adds prognostic information in pulmonary arterial hypertensionQ44453474
Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapyQ44682915
Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney diseaseQ44780252
Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscleQ44805539
The interleukin-6/interleukin-6-receptor system is activated in donor heartsQ48617732
Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis.Q49085974
Nitric oxide-mediated effects of interleukin-6 on [Ca2+]i and cell contraction in cultured chick ventricular myocytes.Q50770745
Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation.Q51764417
RV Contractile Function and its Coupling to Pulmonary Circulation in Heart Failure With Preserved Ejection Fraction: Stratification of Clinical Phenotypes and Outcomes.Q52680478
Echocardiography of Right Ventriculoarterial Coupling Combined With Cardiopulmonary Exercise Testing to Predict Outcome in Heart Failure.Q53326153
Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.Q54504564
Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial HypertensionQ57148895
Prognostic relevance of the echocardiographic assessment of right ventricular function in patients with idiopathic pulmonary arterial hypertensionQ57786248
Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)Q59192167
Negative inotropic effects of cytokines on the heart mediated by nitric oxideQ68208763
The estimation of oxygen consumptionQ71427855
Pulmonary hypertension in rats. 2. Role of interleukin-6Q71791536
Activation of the cardiac interleukin-6 system in advanced heart failureQ74394356
Monocrotaline induces interleukin-6 mRNA expression in rat lungsQ77224638
Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscleQ79830429
Relationship of pulmonary arterial capacitance and mortality in idiopathic pulmonary arterial hypertensionQ82601602
Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular ImagingQ86455840
P433issue3
P304page(s)376-384
P577publication date2017-09-01
P1433published inThe Journal of Heart and Lung TransplantationQ2364382
P1476titleInterleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension
P478volume37

Reverse relations

cites work (P2860)
Q90436104Activation of the Metabolic Master Regulator PPARγ: A Potential PIOneering Therapy for Pulmonary Arterial Hypertension
Q92670725Arterial Hypertension and Interleukins: Potential Therapeutic Target or Future Diagnostic Marker?
Q90159557Association of Mild Echocardiographic Pulmonary Hypertension With Mortality and Right Ventricular Function
Q60363740Classical IL-6 signaling: a promising therapeutic target for pulmonary arterial hypertension
Q92932841Clonally selected primitive endothelial cells promote occlusive pulmonary arteriopathy and severe pulmonary hypertension in rats exposed to chronic hypoxia
Q97524662In the eye of the storm: the right ventricle in COVID-19
Q55155611Inflammatory Mediators Drive Adverse Right Ventricular Remodeling and Dysfunction and Serve as Potential Biomarkers.
Q90166128Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern
Q58745332Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities
Q89996893Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular-Arterial Coupling in Severe Pulmonary Hypertension

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