| review article | Q7318358 |
| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1037754633 |
| P356 | DOI | 10.1023/A:1006819008507 |
| P698 | PubMed publication ID | 9609111 |
| P2093 | author name string | J E Pessin | |
| B P Ceresa | |||
| P2860 | cites work | Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1 | Q24309607 |
| Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2 | Q24315658 | ||
| The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling | Q24336226 | ||
| The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling | Q24337017 | ||
| Role of IRS-2 in insulin and cytokine signalling | Q24337494 | ||
| A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction | Q24338592 | ||
| Activation of ternary complex factor Elk-1 by MAP kinases | Q24564310 | ||
| Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2 | Q24648281 | ||
| Mammalian Ras interacts directly with the serine/threonine kinase Raf | Q27860833 | ||
| Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors | Q28242471 | ||
| Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes | Q28247946 | ||
| The function of GRB2 in linking the insulin receptor to Ras signaling pathways | Q28259867 | ||
| Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling | Q28268458 | ||
| Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase | Q28269621 | ||
| The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product | Q28316871 | ||
| The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 | Q28511655 | ||
| Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21 | Q28573205 | ||
| Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex | Q42824495 | ||
| Activation of mitogen-activated protein kinase and phosphatidylinositol 3'-kinase is not sufficient for the hormonal stimulation of glucose uptake, lipogenesis, or glycogen synthesis in 3T3-L1 adipocytes | Q42829893 | ||
| Differential requirement for p21ras activation in the metabolic signaling by insulin. | Q42830142 | ||
| PHAS-I as a link between mitogen-activated protein kinase and translation initiation | Q42833060 | ||
| Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes. | Q42834509 | ||
| Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation. | Q45244418 | ||
| Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. | Q46027909 | ||
| Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave | Q47986253 | ||
| Epidermal Growth Factor Receptor Targeting Prevents Uncoupling of the Grb2-SOS Complex | Q58197216 | ||
| Integration of MAP kinase signal transduction pathways at the serum response element | Q58415341 | ||
| Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells | Q59079799 | ||
| An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth | Q72284713 | ||
| A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP forma | Q72372408 | ||
| JAK1 kinase forms complexes with interleukin-4 receptor and 4PS/insulin receptor substrate-1-like protein and is activated by interleukin-4 and interleukin-9 in T lymphocytes | Q72724702 | ||
| Insulin receptor substrate-1 (IRS1) and Shc compete for a limited pool of Grb2 in mediating insulin downstream signaling | Q72863907 | ||
| Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin | Q95822391 | ||
| ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation | Q28578241 | ||
| Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6 | Q28609813 | ||
| Insulin-stimulated disassociation of the SOS-Grb2 complex | Q28615780 | ||
| ras genes | Q29547799 | ||
| Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation | Q29616396 | ||
| Divergent mechanisms for homologous desensitization of p21ras by insulin and growth factors | Q30193034 | ||
| MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes. | Q30193038 | ||
| Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos. | Q30193042 | ||
| Role of IRS-1-GRB-2 complexes in insulin signaling | Q30194282 | ||
| Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro | Q33292215 | ||
| Complex formation between RAS and RAF and other protein kinases | Q34351032 | ||
| Ras signaling in the activation of glucose transport by insulin | Q35258436 | ||
| Function of Ras as a molecular switch in signal transduction | Q35536167 | ||
| Regulatory mechanisms for ras proteins | Q36111605 | ||
| The ras signaling pathway mimics insulin action on glucose transporter translocation | Q36300029 | ||
| GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells. | Q36546739 | ||
| Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin | Q36550151 | ||
| Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase | Q36557097 | ||
| Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation | Q36682210 | ||
| Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras | Q37111649 | ||
| Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors | Q38292293 | ||
| The nature and regulation of the insulin receptor: structure and function | Q39494121 | ||
| A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways | Q40021572 | ||
| Ras target proteins in eukaryotic cells | Q40412995 | ||
| Insulin action and the insulin signaling network | Q40545115 | ||
| Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression. | Q40642280 | ||
| Diverse signaling pathways in the cellular actions of insulin | Q40991847 | ||
| Insulin signal transduction and the IRS proteins | Q41048272 | ||
| Insulin stimulation of gene expression mediated by p21ras activation. | Q41080652 | ||
| The insulin-dependent biosynthesis of GLUT1 and GLUT3 glucose transporters in L6 muscle cells is mediated by distinct pathways. Roles of p21ras and pp70 S6 kinase | Q41281641 | ||
| Ligand-dependent intersubunit association within the insulin receptor complex activates its intrinsic kinase activity | Q41334794 | ||
| Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors. | Q41488076 | ||
| Insulin activates p21Ras and guanine nucleotide releasing factor in cells expressing wild type and mutant insulin receptors. | Q41526569 | ||
| Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras | Q41582081 | ||
| Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter | Q41612990 | ||
| An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control | Q41728250 | ||
| Activation of the Ras/mitogen-activated protein kinase signaling pathway alone is not sufficient to induce glucose uptake in 3T3-L1 adipocytes | Q42001983 | ||
| Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation | Q42479687 | ||
| Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway | Q42514245 | ||
| Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation | Q42518876 | ||
| Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. | Q42610778 | ||
| Functional divergence of the MAP kinase pathway. ERK1 and ERK2 activate specific transcription factors | Q42797845 | ||
| Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways | Q42800339 | ||
| Characterization of the mitogen-activated protein kinase/90-kilodalton ribosomal protein S6 kinase signaling pathway in 3T3-L1 adipocytes and its role in insulin-stimulated glucose transport | Q42801942 | ||
| Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins. | Q42811016 | ||
| P433 | issue | 1-2 | |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | 23-29 | |
| P577 | publication date | 1998-05-01 | |
| P1433 | published in | Molecular and Cellular Biochemistry | Q1573176 |
| P1476 | title | Insulin regulation of the Ras activation/inactivation cycle | |
| P478 | volume | 182 |
| Q42448356 | Cardiac Hormones Target the Ras-MEK 1/2-ERK 1/2 Kinase Cancer Signaling Pathways |
| Q42501086 | Chronic exposure to ketone bodies impairs glucose uptake in adult cardiomyocytes in response to insulin but not vanadate: the role of PI3-K. |
| Q78177544 | Coordinate regulation of the alpha(2)-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor by insulin |
| Q46240548 | IGF and insulin receptor signaling in breast cancer. |
| Q38705548 | Inferring Intracellular Signal Transduction Circuitry from Molecular Perturbation Experiments |
| Q33774714 | Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways |
| Q54639986 | Insulin Receptor Substrate Regulation of Phosphoinositide 3-Kinase |
| Q36826889 | Insulin receptor-independent upregulation of cellular glucose uptake |
| Q36023488 | Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms. |
| Q30167694 | Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. |
| Q26852578 | Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectives |
| Q21328702 | PPAR-γ agonists and their effects on IGF-I receptor signaling: Implications for cancer |
| Q42817543 | Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes |
| Q34491332 | Rin1 regulates insulin receptor signal transduction pathways |
| Q37859024 | Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer |
| Q24599871 | The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain |
| Q35972002 | The insulin receptor: a new target for cancer therapy |
| Q34194701 | Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5 |
| Q37403951 | c-Abl and insulin receptor signalling |
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