Rac1 switching at the right time and location is essential for Fcγ receptor-mediated phagosome formation

scientific article published on 9 June 2017

Rac1 switching at the right time and location is essential for Fcγ receptor-mediated phagosome formation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1242/JCS.201749
P698PubMed publication ID28600322

P50authorNobukazu ArakiQ40120517
Yuka IkedaQ95947376
P2093author name stringKatsuhisa Kawai
Youhei Egami
Kyoko Kawamoto
Akira Ikawa
P2860cites workActivation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamicsQ22010790
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane rufflingQ24290667
A genetically encoded photoactivatable Rac controls the motility of living cellsQ24649098
Comparative Anatomy of Phagocytic and Immunological SynapsesQ26767452
The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migrationQ26825105
Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteinsQ27320795
Rac1-dependent lamellipodial motility in prostate cancer PC-3 cells revealed by optogenetic control of Rac1 activityQ27331773
A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosisQ27335399
Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamicsQ27342706
Myosin X is a downstream effector of PI(3)K during phagocytosisQ28114999
Rho GTPases and actin dynamics in membrane protrusions and vesicle traffickingQ28261534
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganizationQ28275839
Inhibition of myosin light chain kinase by p21-activated kinaseQ28678502
Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPasesQ29614245
A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophagesQ29616748
The ARP2/3 complex: an actin nucleator comes of ageQ29617347
Mechanisms of phagocytosis in macrophagesQ29618100
Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2.Q30438474
Spatiotemporal activation of Rac1 for engulfment of apoptotic cellsQ30482535
Sequential signaling in plasma-membrane domains during macropinosome formation in macrophagesQ30489942
Shaping cups into phagosomes and macropinosomesQ30493980
A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosisQ33623817
Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3.Q33899706
Rho family GTPases: more than simple switchesQ34040276
Function of Rho family proteins in actin dynamics during phagocytosis and engulfmentQ34056991
Rho family proteins: coordinating cell responsesQ34446303
Dissecting the roles of Rac1 activation and deactivation in macropinocytosis using microscopic photo-manipulation.Q34909482
Development of an automated fluorescence microscopy system for photomanipulation of genetically encoded photoactivatable proteins (optogenetics) in live cells.Q35093457
Development of an optimized backbone of FRET biosensors for kinases and GTPasesQ35579824
Myosin I links PIP3 signaling to remodeling of the actin cytoskeleton in chemotaxisQ36053577
Myosin I: A new pip(3) effector in chemotaxis and phagocytosisQ36164271
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytesQ36380848
Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis.Q37031442
Measurements of phagocytosis and phagosomal maturationQ37070660
RhoG is required for both FcγR- and CR3-mediated phagocytosisQ39482114
Cofilin contributes to phagocytosis of IgG-opsonized particles but not non-opsonized particles in RAW264 macrophagesQ40120320
Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosisQ40708723
Fc receptor-mediated phagocytosis requires CDC42 and Rac1.Q40997595
Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formationQ42919576
Phosphoinositide-3-kinase-independent contractile activities associated with Fcgamma-receptor-mediated phagocytosis and macropinocytosis in macrophagesQ44249869
Redox-dependent downregulation of Rho by Rac.Q44323617
Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migrationQ48009008
Historical overview of Rho GTPases.Q48527781
Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation.Q52166799
ARHGAP25, a novel Rac GTPase-activating protein, regulates phagocytosis in human neutrophilic granulocytes.Q54338457
Rac1 and Rac2 regulate macrophage morphology but are not essential for migrationQ57909959
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)2530-2540
P577publication date2017-06-09
P1433published inJournal of Cell ScienceQ1524177
P1476titleRac1 switching at the right time and location is essential for Fcγ receptor-mediated phagosome formation
P478volume130

Reverse relations

cites work (P2860)
Q95327288Combined Atomic Force Microscope and Volumetric Light Sheet System for Correlative Force and Fluorescence Mechanobiology Studies
Q61800494Cullin-3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2-positive breast cancer cells
Q47637185RhoC regulates the actin remodeling required for phagosome formation during FcγR-mediated phagocytosis

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