Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice

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Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.274.42.30001
P698PubMed publication ID10514484
P5875ResearchGate publication ID12784970

P50authorDavid M. HoltzmanQ56827171
Anne M FaganQ66909797
P2093author name stringD Schneider
C A Reardon
G Munson
G S Getz
J A Shah
J Lukens
L K Chang
M J LaDu
T Mathur
P2860cites workHuman apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brainQ24309556
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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxinsQ29547593
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Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell lineQ33848287
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Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3Q34229659
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Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer diseaseQ34729047
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Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteinsQ40144506
Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).Q40643050
Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's diseaseQ40849918
Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related proteinQ41150323
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The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complexQ42161240
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Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative StressQ46021433
Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen.Q46030268
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Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitroQ46296108
Clusterin (SGP-2): a multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brainQ46420644
Purification and characterization of brain clusterinQ46450250
Seizure activity causes a rapid increase in sulfated glycoprotein-2 messenger RNA in the adult but not the neonatal rat brainQ46484434
Astrocytic messenger RNA responses to striatal deafferentation in male rat.Q46505757
Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteinsQ46656933
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide depositionQ48601482
Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioningQ48668350
Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob diseaseQ48795523
Expression of the very low-density lipoprotein receptor (VLDL-r), an apolipoprotein-E receptor, in the central nervous system and in Alzheimer's disease.Q49023125
SP-40,40 is a constituent of Alzheimer's amyloidQ53179261
Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filamentsQ59053832
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteinsQ68921833
Electron microscopy of negatively stained lipoproteinsQ68966662
Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactionsQ70478363
Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: association with high density lipoproteinsQ71209926
Expression of apolipoprotein E mRNA in rat microgliaQ71538993
Alzheimer A beta neurotoxicity: promotion by antichymotrypsin, ApoE4; inhibition by A beta-related peptidesQ71727345
Characterization of apolipoprotein J-Alzheimer's A beta interactionQ72132225
Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloidQ72167723
The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasmaQ72362862
Phospholipid transfer protein can transform reconstituted discoidal HDL into vesicular structuresQ74061182
P433issue42
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
astrocyteQ502961
P304page(s)30001-30007
P577publication date1999-10-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleUnique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice
P478volume274