Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells.

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Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells. is …
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scholarly articleQ13442814

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P356DOI10.1007/S11060-010-0273-Y
P698PubMed publication ID20589525

P50authorKatrin SchröderQ42530784
Christian SenftQ52147391
P2093author name stringDonat Kögel
Volker Seifert
Jakob Weissenberger
Maike Priester
Margareth Polacin
P2860cites workAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
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Molecular mechanisms of glioma invasiveness: the role of proteasesQ35166808
Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3.Q36178668
The cause of death in patients with glioblastoma is multifactorial: clinical factors and autopsy findings in 117 cases of supratentorial glioblastoma in adultsQ36423970
Stat3 promotes metastatic progression of prostate cancer.Q36691140
Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implicationsQ36749049
Diffuse glioma growth: a guerilla warQ36931690
Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma.Q36952294
Overcoming the innate immune response to small interfering RNA.Q37071130
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A novel tool to analyze MRI recurrence patterns in glioblastomaQ37284341
Concomitant reduction of matrix metalloproteinase-2 secretion and intracellular reactive oxygen species following anti-sense inhibition of telomerase activity in PC-3 prostate carcinoma cellsQ38323696
Stat3 regulates genes common to both wound healing and cancerQ38329956
Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylatorsQ39933616
Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness.Q39975221
Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cellsQ39991492
Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cellsQ40685493
Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2).Q42816271
Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1.Q42818520
STAT3 tyrosine phosphorylation influences survival in glioblastomaQ43068296
Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitorQ44290335
Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasisQ47677996
IL-6 is required for glioma development in a mouse modelQ47817716
Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomasQ48226453
The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with EGFR amplification.Q55466683
P433issue3
P921main subjectglioblastomaQ282142
P304page(s)393-403
P577publication date2010-06-30
P1433published inJournal of Neuro-OncologyQ15752119
P1476titleInhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells
P478volume101

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cites work (P2860)
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