Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase

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Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase is …
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P6179Dimensions Publication ID1100592821
P356DOI10.1038/S41598-017-19135-7
P8608Fatcat IDrelease_nd5jno3zkzaqjgcevg45enpmpa
P932PMC publication ID5789057
P698PubMed publication ID29379013

P50authorNikolai ZvonokQ83904178
Alexandros MakriyannisQ28480394
Jeffrey W. HudgensQ46112986
P2093author name stringXiaoyu Ma
Sergiy Tyukhtenko
Hongwei Huang
Kiran Vemuri
Spiro Pavlopoulos
Ioannis Karageorgos
Elyssia S Gallagher
Girija Rajarshi
Mahmoud L Nasr
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The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymesQ27678921
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cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidasesQ28252158
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Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesisQ33914549
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Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury.Q35143497
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Specific Inter-residue Interactions as Determinants of Human Monoacylglycerol Lipase Catalytic Competency: A ROLE FOR GLOBAL CONFORMATIONAL CHANGES.Q36548313
Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoireQ36949890
Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent miceQ37214542
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Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry studyQ37374110
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signalingQ37416400
Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neuronsQ37444504
Monoacylglycerol lipase inhibitors produce pro- or antidepressant responses via hippocampal CA1 GABAergic synapsesQ37617606
In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects.Q37637750
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Catalytic contributions from remote regions of enzyme structureQ37933310
Functional role of a non-active site residue Trp(23) on the enzyme activity of Escherichia coli thioesterase I/protease I/lysophospholipase L(1).Q38353030
From local to global changes in proteins: a network viewQ38384421
Controlling Allosteric Networks in ProteinsQ38740825
Using THz Spectroscopy, Evolutionary Network Analysis Methods, and MD Simulation to Map the Evolution of Allosteric Communication Pathways in c-Type LysozymesQ40576749
A comparison of novel, selective fatty acid amide hydrolase (FAAH), monoacyglycerol lipase (MAGL) or dual FAAH/MAGL inhibitors to suppress acute and anticipatory nausea in rat modelsQ41155213
Sequential structural changes of Escherichia coli thioesterase/protease I in the serial formation of Michaelis and tetrahedral complexes with diethyl p-nitrophenyl phosphate.Q44503660
Roles of tryptophan residues on the Rhizopus delemar lipase activity: chemical modification in a water-olive oil emulsionQ47922231
Conformational transition pathway in the inhibitor binding process of human monoacylglycerol lipaseQ48628554
Systematic mutation of bacteriophage T4 lysozymeQ50183536
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)1719
P577publication date2018-01-29
P1433published inScientific ReportsQ2261792
P1476titleEffects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase
P478volume8

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cites work (P2860)
Q89597584A Thermolabile Phospholipase B from Talaromyces marneffei GD-0079: Biochemical Characterization and Structure Dynamics Study
Q101051220Conformational gating, dynamics and allostery in human monoacylglycerol lipase
Q64273189Structural Perspective on Revealing and Altering Molecular Functions of Genetic Variants Linked with Diseases
Q64262145Structural and free energy landscape of novel mutations in ribosomal protein S1 (rpsA) associated with pyrazinamide resistance