Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease.

scientific article

Adipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2217/RME.15.17
P8608Fatcat IDrelease_kuo3ckhhonbntice6h7ex6tumi
P698PubMed publication ID26022763
P5875ResearchGate publication ID277407807

P50authorBarbara SteinerQ52085411
Andreas KurtzQ52882382
Manfred GossenQ63006891
Anne SchwerkQ85000424
P2093author name stringChristine Winter
Levent Akyüz
Jürgen Berg
Jennifer Altschüler
Manfred Roch
P2860cites workNeural stem cell niches in health and diseasesQ26995185
Immunobiology of mesenchymal stem cellsQ27004487
Staging of brain pathology related to sporadic Parkinson's diseaseQ28131702
Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrierQ28257034
Interleukin-10 regulates progenitor differentiation and modulates neurogenesis in adult brainQ28571642
Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brainsQ28578487
Connexin 26 and basic fibroblast growth factor are expressed primarily in the subpial and subependymal layers in adult brain parenchyma: roles in stem cell proliferation and morphological plasticity?Q28582333
Human mesenchymal stem cells reprogram adult cardiomyocytes toward a progenitor-like state through partial cell fusion and mitochondria transfer.Q30513977
Nestin- and doublecortin-positive cells reside in adult spinal cord meninges and participate in injury-induced parenchymal reaction.Q30525599
Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.Q31039577
Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiationQ33202256
Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic interventionQ33663970
Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissueQ33723606
Gene silencing as a threat to the success of gene therapyQ33843166
Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosisQ34256627
Silencing of gene expression: implications for design of retrovirus vectorsQ34323213
Dopamine depletion impairs precursor cell proliferation in Parkinson disease.Q34326801
Mesengenic potential and future clinical perspective of human processed lipoaspirate cellsQ35203286
In vivo tracking of stem cells for clinical trials in cardiovascular diseaseQ35959118
Retrovirus silencing and vector design: relevance to normal and cancer stem cells?Q36230366
In vivo evidence that erythropoietin protects neurons from ischemic damageQ36477827
Behavioral models of Parkinson's disease in rodents: a new look at an old problemQ36531775
Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's diseaseQ36671837
The anterior olfactory nucleus in Parkinson's diseaseQ36691553
Human interleukin-10 gene transfer is protective in a rat model of Parkinson's diseaseQ37300999
Neurobiology and treatment of Parkinson's diseaseQ37337617
Rodent models of Parkinson's disease: beyond the motor symptomatologyQ37343565
Mesenchymal stem cell homing: the devil is in the detailsQ37407769
Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous systemQ37480311
Immunosuppressive properties of mesenchymal stem cellsQ37926524
Olfactory dysfunction in Parkinson diseaseQ38009992
Human adipose-derived mesenchymal stromal cells increase endogenous neurogenesis in the rat subventricular zone acutely after 6-hydroxydopamine lesioning.Q38302618
Mesenchymal stem cells augment neurogenesis in the subventricular zone and enhance differentiation of neural precursor cells into dopaminergic neurons in the substantia nigra of a parkinsonian modelQ39623128
Transplantation of undifferentiated human mesenchymal stem cells protects against 6-hydroxydopamine neurotoxicity in the rat.Q39776151
Reversal of dopaminergic degeneration in a parkinsonian rat following micrografting of human bone marrow-derived neural progenitorsQ39792829
alpha-Synucleinopathy in the human olfactory system in Parkinson's disease: involvement of calcium-binding protein- and substance P-positive cells.Q39883880
AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 miceQ39893541
Neurorescue effects of VEGF on a rat model of Parkinson's diseaseQ40393076
Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brainsQ40823270
Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson's disease in the mouseQ42089098
The relation between cognition and motor dysfunction in drug-naive newly diagnosed patients with Parkinson's diseaseQ42604425
Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease.Q43234179
Leptomeningeal-derived doublecortin-expressing cells in poststroke brainQ43245986
Evaluation of senescence in mesenchymal stem cells isolated from equine bone marrow, adipose tissue, and umbilical cord tissueQ44038136
Do adipose tissue-derived mesenchymal stem cells ameliorate Parkinson's disease in rat model?Q46332910
Histological, behavioural and neurochemical evaluation of medial forebrain bundle and striatal 6-OHDA lesions as rat models of Parkinson's diseaseQ46452329
Mesenchymal stem cells therapy exerts neuroprotection in a progressive animal model of Parkinson's diseaseQ46456058
Neural differentiation ability of mesenchymal stromal cells from bone marrow and adipose tissue: a comparative studyQ47239479
Differential regulation of gliogenesis in the context of adult hippocampal neurogenesis in miceQ48003056
Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's diseaseQ48132256
Postnatal changes in the distribution and morphology of rat substantia nigra dopaminergic neuronsQ48135577
Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesionsQ48240667
Parkinson's disease is associated with hippocampal atrophyQ48275995
Intrahippocampal transplantation of mesenchymal stromal cells promotes neuroplasticityQ48451318
Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration.Q48515308
MPTP-induced hippocampal effects on serotonin, dopamine, neurotrophins, adult neurogenesis and depression-like behavior are partially influenced by fluoxetine in adult miceQ48558309
Telocytes in meninges and choroid plexus.Q48559999
Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's diseaseQ48730943
Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.Q48876521
Ischemia-induced neural stem/progenitor cells in the pia mater following cortical infarctionQ48951604
Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusionQ49047090
Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease.Q50527409
Cytokine profile of human adipose-derived stem cells: expression of angiogenic, hematopoietic, and pro-inflammatory factors.Q50685836
Cell-based therapies: from basic biology to replacement, repair, and regeneration.Q50939047
Comparison of immunological properties of bone marrow stromal cells and adipose tissue-derived stem cells before and after osteogenic differentiation in vitro.Q50998508
Subtypes of mild cognitive impairment in Parkinson's disease: progression to dementia.Q51916987
Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study.Q51949961
Human adipose-derived mesenchymal stem cells improve motor functions and are neuroprotective in the 6-hydroxydopamine-rat model for Parkinson's disease when cultured in monolayer cultures but suppress hippocampal neurogenesis and hippocampal memory fQ56966730
P433issue4
P304page(s)431-446
P577publication date2015-05-01
P1433published inRegenerative MedicineQ19921466
P1476titleAdipose-derived human mesenchymal stem cells induce long-term neurogenic and anti-inflammatory effects and improve cognitive but not motor performance in a rat model of Parkinson's disease
P478volume10

Reverse relations

cites work (P2860)
Q28071698Adipose Tissue-Derived Stem Cells in Regenerative Medicine
Q42511103Adipose tissue-derived stromal cells (ADSC) express oligodendrocyte and myelin markers, but they do not function as oligodendrocytes
Q55667027Adipose-derived Stem Cells Stimulated with n-Butylidenephthalide Exhibit Therapeutic Effects in a Mouse Model of Parkinson's Disease.
Q44704967Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis
Q104142348Challenges and translational considerations of mesenchymal stem/stromal cell therapy for Parkinson's disease
Q92503989Differentiation of adult human mesenchymal stem cells into dopaminergic neurons
Q42061102Dynamics of plasma membrane surface related to the release of extracellular vesicles by mesenchymal stem cells in culture
Q47941437Functional role of mesenchymal stem cells in the treatment of chronic neurodegenerative diseases.
Q45862169Gene therapy with mesenchymal stem cells expressing IFN-ß ameliorates neuroinflammation in experimental models of multiple sclerosis
Q52641800Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking.
Q64767457Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases
Q92022019Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer's disease
Q91712794Mesenchymal stem cells in neurodegenerative diseases: Opinion review on ethical dilemmas
Q50780004Platelet Rich Plasma Augments Adipose-Derived Stem Cell Growth and Differentiation.
Q48304585Regenerative medicine for Parkinson's disease using differentiated nerve cells derived from human buccal fat pad stem cells
Q38691406Therapeutic approaches in Parkinson's disease and related disorders