The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity.

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The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00018-017-2722-7
P932PMC publication ID6318120
P698PubMed publication ID29218600

P50authorGeert BultynckQ38326487
P2093author name stringNan Wang
Luc Leybaert
Jean X Jiang
Catheleyne D'hondt
Jegan Iyyathurai
P2860cites workAt the cross-point of connexins, calcium, and ATP: blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries.Q49151661
Gap junction proteins connexin32 and connexin43 partially acquire growth-suppressive function in HeLa cells by deletion of their C-terminal tails.Q53418326
Thrombin inhibits intercellular calcium wave propagation in corneal endothelial cells by modulation of hemichannels and gap junctions.Q54564783
Characterization of the pH-dependent Interaction between the Gap Junction Protein Connexin43 Carboxyl Terminus and Cytoplasmic Loop DomainsQ59241282
Mechanism of blebbistatin inhibition of myosin IIQ28267628
Modifications in the biophysical properties of connexin43 channels by a peptide of the cytoplasmic loop regionQ28909772
Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1Q28909825
A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype.Q30579545
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in cultureQ33898269
Intramolecular interactions mediate pH regulation of connexin43 channelsQ34017364
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytesQ34378150
Protter: interactive protein feature visualization and integration with experimental proteomic dataQ35026816
Structural bases for the chemical regulation of Connexin43 channelsQ35749965
Calcium Wave Propagation Triggered by Local Mechanical Stimulation as a Method for Studying Gap Junctions and HemichannelsQ36024763
Biological role of connexin intercellular channels and hemichannelsQ36035603
Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotectionQ36141133
Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion.Q36912901
The contractile system as a negative regulator of the connexin 43 hemichannel.Q37989192
Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: gap junctions versus hemichannelsQ38105790
Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening.Q38134462
Regulation of connexin36 gap junction channels by n-alkanols and arachidonic acidQ39192231
Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activityQ39679630
Novel pharmacophores of connexin43 based on the "RXP" series of Cx43-binding peptidesQ39833047
Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loadingQ39954576
Mechanical stimulation-induced calcium wave propagation in cell monolayers: the example of bovine corneal endothelial cellsQ41836953
Intracellular calcium changes trigger connexin 32 hemichannel openingQ41886797
Design and characterization of the first peptidomimetic molecule that prevents acidification-induced closure of cardiac gap junctionsQ42053547
Hemichannels; from the molecule to the functionQ42184897
Ca(2+) regulation of connexin 43 hemichannels in C6 glioma and glial cellsQ43298205
pH-dependent intramolecular binding and structure involving Cx43 cytoplasmic domainsQ44085071
Negatively charged residues (Asp378 and Asp379) in the last ten amino acids of the C-terminal tail of Cx43 hemichannels are essential for loop/tail interactionsQ44812355
ATP release through connexin hemichannels in corneal endothelial cellsQ46404423
The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellular calcium wave propagation in corneal endothelial cellsQ46492691
Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia.Q46852205
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological ImplicationsQ47770967
Nutrient Starvation Decreases Cx43 Levels and Limits Intercellular Communication in Primary Bovine Corneal Endothelial CellsQ48909500
A 17mer peptide interferes with acidification-induced uncoupling of connexin43.Q48940537
P433issue11
P304page(s)2059-2073
P577publication date2017-12-07
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleThe SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity
P478volume75

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cites work (P2860)
Q90638439Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage
Q92703374Involvement of the Gap Junction Protein, Connexin43, in the Formation and Function of Invadopodia in the Human U251 Glioblastoma Cell Line
Q88308941Lipidated connexin mimetic peptides potently inhibit gap junction-mediated Ca2+-wave propagation
Q55026641Mechanisms of ATP Release by Inflammatory Cells.
Q55456964Novel approach to temozolomide resistance in malignant glioma: connexin43-directed therapeutics.
Q92369568Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke
Q49804036The Connexin Mimetic Peptide Gap27 and Cx43-Knockdown Reveal Differential Roles for Connexin43 in Wound Closure Events in Skin Model Systems