A trivalent Apx-fusion protein delivered by E. coli outer membrane vesicles induce protection against Actinobacillus pleuropneumoniae of serotype 1 and 7 challenge in a murine model.

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A trivalent Apx-fusion protein delivered by E. coli outer membrane vesicles induce protection against Actinobacillus pleuropneumoniae of serotype 1 and 7 challenge in a murine model. is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0191286
P932PMC publication ID5786296
P698PubMed publication ID29373591

P50authorSanjie CaoQ87623219
P2093author name stringYong Huang
Rui Wu
Qin Zhao
Kui Xu
Xiaobo Huang
Yung-Fu Chang
Qigui Yan
Xintian Wen
Xiaoping Ma
Yiping Wen
Xinfeng Han
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Delivery of foreign antigens by engineered outer membrane vesicle vaccinesQ33733590
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Bacterial outer membrane vesicles and the host-pathogen interactionQ34468123
Mechanistic insight into the TH1-biased immune response to recombinant subunit vaccines delivered by probiotic bacteria-derived outer membrane vesiclesQ34576021
Evaluation of a Killed Vaccine Against Porcine Pleuropneumonia Due to Haemophilus pleuropneumoniaeQ35191763
A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane VesiclesQ36050505
Membrane vesicle-mediated release of bacterial RNAQ36181226
Molecular analysis of the Actinobacillus pleuropneumoniae RTX toxin-III gene clusterQ36782965
Employing Escherichia coli-derived outer membrane vesicles as an antigen delivery platform elicits protective immunity against Acinetobacter baumannii infectionQ37416593
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Immunization with Escherichia coli outer membrane vesicles protects bacteria-induced lethality via Th1 and Th17 cell responses.Q53115452
Submerged cultivation of Ganoderma lucidum and the effects of its polysaccharides on the production of human cytokines TNF-α, IL-12, IFN-γ, IL-2, IL-4, IL-10 and IL-17.Q53485947
Development of a multiplex PCR test for identification of Actinobacillus pleuropneumoniae serovars 1, 7, and 12.Q54527602
Actinobacillus pleuropneumoniae RTX-toxins: uniform designation of haemolysins, cytolysins, pleurotoxin and their genesQ70505421
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Chemical composition, mass size distribution and source analysis of long-range transported wildfire smokes in HelsinkiQ39733128
The Actinobacillus pleuropneumoniae hemolysin determinant: unlinked appCA and appBD loci flanked by pseudogenesQ39942767
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Actinobacillus pleuropneumoniae two-component system QseB/QseC regulates the transcription of PilM, an important determinant of bacterial adherence and virulenceQ41184289
Actinobacillus pleuropneumoniae infections in pigs: the role of virulence factors in pathogenesis and protectionQ41695502
Deletion analysis resolves cell-binding and lytic domains of the Pasteurella leukotoxinQ41716992
Identification of conserved surface proteins as novel antigenic vaccine candidates of Actinobacillus pleuropneumoniaeQ42280764
Immunogenicity and protective efficacy of recombinant Haemophilus parasuis SH0165 putative outer membrane proteinsQ42286672
Cloning and characterization of a hemolysin gene from Actinobacillus (Haemophilus) pleuropneumoniaeQ42645527
Secretion of the Pasteurella leukotoxin by Escherichia coliQ44163218
Targeted nanotherapy for induction of therapeutic immune responsesQ44256295
EDTA-induced membrane fluidization and destabilization: biophysical studies on artificial lipid membranesQ46909434
Sequence analysis of leukotoxin secretion determinants from aPasteurella haemolytica-like organismQ48076713
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
Actinobacillus pleuropneumoniaeQ343332
P304page(s)e0191286
P577publication date2018-01-26
P1433published inPLOS OneQ564954
P1476titleA trivalent Apx-fusion protein delivered by E. coli outer membrane vesicles induce protection against Actinobacillus pleuropneumoniae of serotype 1 and 7 challenge in a murine model
P478volume13

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cites work (P2860)
Q60045649Bacterial outer membrane vesicles, a potential vaccine candidate in interactions with host cells based
Q60921407Cytoplasmic glycoengineering of Apx toxin fragments in the development of Actinobacillus pleuropneumoniae glycoconjugate vaccines
Q89992810Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy
Q64286724Development of ApxI, ApxII, and ApxIII-specific ELISA methods for evaluation of vaccine efficiency

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