Structure-Based Design and Synthesis of Harmine Derivatives with Different Selectivity Profiles in Kinase versus Monoamine Oxidase Inhibition.

scientific article

Structure-Based Design and Synthesis of Harmine Derivatives with Different Selectivity Profiles in Kinase versus Monoamine Oxidase Inhibition. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/CMDC.201600539
P698PubMed publication ID28264138

P50authorAndrás KotschyQ73252492
P2093author name stringCsaba Wéber
Francisco Cruzalegui
Balázs Bálint
Mike Burbridge
P2860cites workSequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinasesQ24316021
The selectivity of protein kinase inhibitors: a further updateQ24654622
Structure of human monoamine oxidase A at 2.2-A resolution: The control of opening the entry for substrates/inhibitorsQ27650239
Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1AQ27665397
The effect of deprenyl (selegiline) on the natural history of Parkinson's diseaseQ28243994
The role of DYRK1A in neurodegenerative diseasesQ34642120
Down syndrome--recent progress and future prospectsQ34964947
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replicationQ36402679
MNB/DYRK1A as a multiple regulator of neuronal developmentQ37820722
Synthesis and biological evaluation of N(9)-substituted harmine derivatives as potential anticancer agentsQ38758935
Synthesis, cytotoxic, anti-lipoxygenase and anti-acetylcholinesterase capacities of novel derivatives from harmine.Q38782393
Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4Q41739576
Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.Q42091667
Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.Q42630760
A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro.Q42702995
High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brainQ46629739
First selective dual inhibitors of tau phosphorylation and Beta-amyloid aggregation, two major pathogenic mechanisms in Alzheimer's diseaseQ48523309
Computational & experimental evaluation of the structure/activity relationship of β-carbolines as DYRK1A inhibitors.Q55071094
Localization of monoamine oxidases in human peripheral tissuesQ61849213
P433issue12
P304page(s)932-939
P577publication date2017-04-06
P1433published inChemMedChemQ2962252
P1476titleStructure-Based Design and Synthesis of Harmine Derivatives with Different Selectivity Profiles in Kinase versus Monoamine Oxidase Inhibition
P478volume12

Reverse relations

cites work (P2860)
Q96958956A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877
Q90610025Development of Kinase-Selective, Harmine-Based DYRK1A Inhibitors that Induce Pancreatic Human β-Cell Proliferation
Q54107922Isoform selectivity of harmine-conjugated 1,2,3-triazoles against human monoamine oxidase.

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