γ-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma.

scientific article

γ-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/IJC.31115
P698PubMed publication ID29047105

P50authorZhi-Jun SunQ87814766
P2093author name stringLei Wu
Bing Liu
Lu Zhang
Ashok B Kulkarni
Jian-Feng Liu
Liang Mao
Wen-Feng Zhang
Zhi-Li Zhao
Wei-Wei Deng
Guang-Tao Yu
Lin-Lin Bu
Yi-Cun Li
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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1Q29614651
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Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established TumorsQ33707098
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Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model.Q36295853
ROR1C Regulates Differentiation of Myeloid-Derived Suppressor CellsQ36345203
CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage DifferentiationQ36595788
NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell.Q36830276
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MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinomaQ36863089
Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling.Q36963408
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Cooperative regulation of NOTCH1 protein-phosphatidylinositol 3-kinase (PI3K) signaling by NOD1, NOD2, and TLR2 receptors renders enhanced refractoriness to transforming growth factor-beta (TGF-beta)- or cytotoxic T-lymphocyte antigen 4 (CTLA-4)-medQ38420016
The Notch pathway in colorectal cancerQ38564689
Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated MacrophagesQ38804285
Myeloid-derived suppressor cells as effectors of immune suppression in cancer.Q38864758
Endothelial cell-secreted EGF induces epithelial to mesenchymal transition and endows head and neck cancer cells with stem-like phenotypeQ39009747
Mouse and human Notch-1 regulate mucosal immune responses.Q39034381
Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma.Q39238857
B7-H4 expression indicates poor prognosis of oral squamous cell carcinomaQ39627356
Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responsesQ39700430
Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3+ Tregs.Q42492427
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecthead and neck squamous cell carcinomaQ18348812
P1104number of pages11
P304page(s)999-1009
P577publication date2017-11-02
P1433published inInternational Journal of CancerQ332492
P1476titleγ-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma
P478volume142

Reverse relations

cites work (P2860)
Q92060208A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase-mediated activation of Notch signaling
Q90398004FLI-06 Intercepts Notch Signaling And Suppresses The Proliferation And Self-renewal Of Tongue Cancer Cells
Q57283037Inhibiting Notch1 enhances immunotherapy efficacy in melanoma by preventing Notch1 dependent immune suppressive properties
Q92731408Modulation of Immunosuppression by Oligonucleotide-Based Molecules and Small Molecules Targeting Myeloid-Derived Suppressor Cells
Q59791901Moving Breast Cancer Therapy up a Notch
Q55210384Notch Signaling in Macrophages in the Context of Cancer Immunity.
Q58572862Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer
Q89771836Overview of Basic Mechanisms of Notch Signaling in Development and Disease
Q92366436Precision medicine for human cancers with Notch signaling dysregulation (Review)
Q89587286Shaping of the Tumor Microenvironment by Notch Signaling
Q92642526Targeting Cellular Metabolism Modulates Head and Neck Oncogenesis
Q52571053Targeting Notch signalling pathway of cancer stem cells.

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