DS-8201a, a new HER2-targeting antibody-drug conjugate incorporating a novel DNA topoisomerase I inhibitor, overcomes HER2-positive gastric cancer T-DM1 resistance.

scientific article

DS-8201a, a new HER2-targeting antibody-drug conjugate incorporating a novel DNA topoisomerase I inhibitor, overcomes HER2-positive gastric cancer T-DM1 resistance. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/IJC.30870
P698PubMed publication ID28677116

P50authorKimio YonesakaQ88448810
Junji TsurutaniQ88448814
P2093author name stringKazuhiko Nakagawa
Kazuto Nishio
Osamu Maenishi
Takao Tamura
Kazuko Sakai
Naoki Takegawa
Yoshikane Nonagase
Yusuke Ogitani
P2860cites workUse of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.Q27824766
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Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneityQ37098302
Assessment of a HER2 scoring system for gastric cancer: results from a validation studyQ37142266
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Heregulin-expressing HER2-positive breast and gastric cancer exhibited heterogeneous susceptibility to the anti-HER2 agents lapatinib, trastuzumab and T-DM1.Q37709032
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DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variantQ41094672
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Overexpression of Grb2/HER2 signaling in Chinese gastric cancer: their relationship with clinicopathological parameters and prognostic significance.Q51741363
DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1.Q54204362
Ado-trastuzumab Emtansine (T-DM1): an antibody-drug conjugate (ADC) for HER2-positive breast cancer.Q54342129
Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome.Q54578578
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P433issue8
P407language of work or nameEnglishQ1860
P304page(s)1682-1689
P577publication date2017-07-12
P1433published inInternational Journal of CancerQ332492
P1476titleDS-8201a, a new HER2-targeting antibody-drug conjugate incorporating a novel DNA topoisomerase I inhibitor, overcomes HER2-positive gastric cancer T-DM1 resistance
P478volume141