Beneficial interaction between clobenpropit and pyridoxine in prevention of electroshock-induced seizures in mice: lack of histaminergic mechanisms.

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Beneficial interaction between clobenpropit and pyridoxine in prevention of electroshock-induced seizures in mice: lack of histaminergic mechanisms. is …
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scholarly articleQ13442814

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P356DOI10.1177/0960327110372398
P698PubMed publication ID20511290

P50authorDivya VohoraQ43145694
Razia KhanamQ82418116
P2093author name stringA Manocha
P Uma Devi
P2860cites workThe histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neuronsQ28292338
Autoinhibition of histamine synthesis mediated by presynaptic H3-receptorsQ28338480
Involvement of central histamine in amygdaloid kindled seizures in ratsQ34097939
Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptorQ34249836
Seizure activity in pyridoxine-deficient adult ratsQ41113886
Histamine and selective H3-receptor ligands: a possible role in the mechanism and management of epilepsyQ43722658
Development of amygdaloid kindling in histidine decarboxylase-deficient and histamine H1 receptor-deficient miceQ44805056
Role of histaminergic neurons in development of epileptic seizures in EL miceQ45153402
Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in miceQ48087726
Dietary pyridoxine interaction with tryptophan or histidine on brain serotonin and histamine metabolismQ48102576
Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient ratsQ48225718
Deep brain stimulation of the posterior hypothalamus activates the histaminergic system to exert antiepileptic effect in rat pentylenetetrazol modelQ48262417
In vivo modulation of rat hypothalamic histamine release by the histamine H3 receptor ligands, immepip and clobenpropit. Effects of intrahypothalamic and peripheral application.Q48317100
Lesion of the tuberomammillary nucleus E2-region attenuates postictal seizure protection in ratsQ48349978
GABA-like immunoreactivity in the tuberomammillary nucleus: an electron microscopic study in the rat.Q48768441
Relationships between pyridoxal phosphate availability, activity of vitamin B6-dependent enzymes and convulsionsQ48819885
Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures.Q51393707
P433issue1
P921main subjectpyridoxineQ423746
clobenpropitQ5134762
P304page(s)84-88
P577publication date2010-05-28
P1433published inHuman & Experimental ToxicologyQ1636500
P1476titleBeneficial interaction between clobenpropit and pyridoxine in prevention of electroshock-induced seizures in mice: lack of histaminergic mechanisms
P478volume30