Therapeutic doses of doxorubicin induce premature senescence of human mesenchymal stem cells derived from menstrual blood, bone marrow and adipose tissue

scientific article published on 11 October 2017

Therapeutic doses of doxorubicin induce premature senescence of human mesenchymal stem cells derived from menstrual blood, bone marrow and adipose tissue is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12185-017-2346-6
P698PubMed publication ID29022209

P50authorIrina KozhukharovaQ57013148
P2093author name stringVictoria Zemelko
Nikolay Nikolsky
Olga Lyublinskaya
Larisa Alekseenko
Zoya Kovaleva
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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicityQ29614981
p53-dependent apoptosis modulates the cytotoxicity of anticancer agentsQ29615031
The senescence-associated secretory phenotype: the dark side of tumor suppressionQ29620106
Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty AcidsQ58319926
Differentiation-related response to DNA breaks in human mesenchymal stem cellsQ64386387
Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen speciesQ74014516
Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathwaysQ81158469
???Q62633203
Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healingQ33326623
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicinQ33540751
Survival responses of human embryonic stem cells to DNA damageQ34078474
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Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functionsQ35171563
Persistent DNA damage-induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells.Q35390924
A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome.Q37124125
Sublethal oxidative stress induces the premature senescence of human mesenchymal stem cells derived from endometriumQ37156197
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.Q37345878
Doxorubicin: the good, the bad and the ugly effectQ37528487
gammaH2AX: a sensitive molecular marker of DNA damage and repairQ37687078
Brain-derived neurotrophic factor attenuates doxorubicin-induced cardiac dysfunction through activating Akt signalling in ratsQ37693349
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Doxorubicin Affects Expression of Proteins of Neuronal Pathways in MCF-7 Breast Cancer CellsQ38400621
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Senescence as a general cellular response to stress: A mini-reviewQ38598950
Sublethal heat shock induces premature senescence rather than apoptosis in human mesenchymal stem cells.Q38687525
Doxorubicin induces the DNA damage response in cultured human mesenchymal stem cells.Q39257323
DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cellsQ39703300
Tissue-specific Differentiation Potency of Mesenchymal Stromal Cells from Perinatal TissuesQ39863008
Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth.Q40195961
The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosisQ40300478
Evaluation of chemosensitivity of human bone marrow stromal cells--differences between common chemotherapeutic drugs.Q40316982
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaksQ40593721
Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathwayQ40624347
Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell functionQ41883542
Reactive Oxygen Species Are Required for Human Mesenchymal Stem Cells to Initiate Proliferation after the Quiescence ExitQ42141820
High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cellsQ42506988
Doxorubicin has in vivo toxicological effects on ex vivo cultured mesenchymal stem cells.Q42708123
Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis.Q43121021
Caspase inhibition switches doxorubicin-induced apoptosis to senescenceQ44438871
Doxorubicin caused apoptosis of mesenchymal stem cells via p38, JNK and p53 pathway.Q45929499
Transdifferentiation of bone marrow stromal cells into cholinergic neuronal phenotype: a potential source for cell therapy in spinal cord injuryQ46104110
Activation of DNA damage response signaling in mouse embryonic stem cellsQ46372405
Neuronal differentiation potential of human adipose-derived mesenchymal stem cells.Q46531960
Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damageQ46887314
Effects of high-dose chemotherapy on bone marrow multipotent mesenchymal stromal cells isolated from lymphoma patients.Q54442482
Doxorubicin induces senescence and impairs function of human cardiac progenitor cells.Q54449632
P921main subjectmenstruationQ12171
doxorubicinQ18936
P577publication date2017-10-11
P1433published inInternational Journal of HematologyQ6051416
P1476titleTherapeutic doses of doxorubicin induce premature senescence of human mesenchymal stem cells derived from menstrual blood, bone marrow and adipose tissue

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cites work (P2860)
Q89657824Cell-Based Nanoparticles Delivery Systems for Targeted Cancer Therapy: Lessons from Anti-Angiogenesis Treatments
Q98178384Development of Natural-Based Bone Cement for a Controlled Doxorubicin-Drug Release
Q61801033High doses of synthetic antioxidants induce premature senescence in cultivated mesenchymal stem cells
Q93147053Mesenchymal Stem Cell Therapy for Doxorubicin-Induced Cardiomyopathy: Potential Mechanisms, Governing Factors, and Implications of the Heart Stem Cell Debate
Q61455264Quiescent Human Mesenchymal Stem Cells Are More Resistant to Heat Stress than Cycling Cells
Q96954753Three-Dimensional Compaction Switches Stress Response Programs and Enhances Therapeutic Efficacy of Endometrial Mesenchymal Stem/Stromal Cells

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