An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma

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An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/LEU.2017.203
P698PubMed publication ID28659618

P50authorThilo BrachtQ57165790
P2093author name stringM Schneider
L Klein-Hitpass
R Küppers
S Hartmann
M-L Hansmann
M A Weniger
B Sitek
J Arnolds
A L Weiß
A Lollies
P2860cites workCooperative epigenetic modulation by cancer amplicon genesQ24608701
Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphomaQ24672476
The biology and management of systemic anaplastic large cell lymphomaQ27009497
Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell ImmunityQ27489852
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell deathQ28202067
A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell linesQ28235071
Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphomaQ39284003
AP-1 mediated relief of repressive activity of the CD30 promoter microsatellite in Hodgkin and Reed-Sternberg cellsQ39392332
Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.Q39647760
Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma.Q39816246
c-Jun expression and activation are restricted to CD30+ lymphoproliferative disordersQ40166030
JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg cells of Hodgkin lymphomaQ40377891
Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysisQ42097322
JunB expression is a common feature of CD30+ lymphomas and lymphomatoid papulosisQ42278940
The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway.Q42835267
The proto-oncogene MYC is required for selection in the germinal center and cyclic reentryQ43091743
The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK+ anaplastic large cell lymphoma.Q54327994
Detection of genomic imbalances in microdissected Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma by array-based comparative genomic hybridization.Q54523702
Genomic profiling reveals different genetic aberrations in systemic ALK-positive and ALK-negative anaplastic large cell lymphomas.Q54546572
Expression pattern of MUM1/IRF4 in the spectrum of pathology of Hodgkin's diseaseQ59647766
Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cellsQ73453075
Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphomaQ77461381
AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular featuresQ81385857
The case of the missing c-MycQ85227334
Expression profiles of MYC protein and MYC gene rearrangement in lymphomasQ86515333
Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alphaQ28289924
Oncogenically active MYD88 mutations in human lymphomaQ28301648
Compensatory dendritic cell development mediated by BATF-IRF interactionsQ28586184
BATF-JUN is critical for IRF4-mediated transcription in T cellsQ28590152
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphomaQ28649793
Deep sequencing of MYC DNA-binding sites in Burkitt lymphomaQ28742928
AP-1: a double-edged sword in tumorigenesisQ30014831
Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulationQ33236181
Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasmsQ34099059
Gene expression profiling of microdissected Hodgkin Reed-Sternberg cells correlates with treatment outcome in classical Hodgkin lymphomaQ34407534
Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphomaQ34408939
Profiling of Hodgkin's lymphoma cell line L1236 and germinal center B cells: identification of Hodgkin's lymphoma-specific genesQ34520636
The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cellsQ34693140
Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphomaQ35095028
Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapyQ35875897
Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of developmentQ35888216
Overexpression of Batf induces an apoptotic defect and an associated lymphoproliferative disorder in miceQ36004222
Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.Q36367466
Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomasQ36407235
Recurrent somatic loss of TNFRSF14 in classical Hodgkin lymphomaQ36463861
Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphomaQ36508931
IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesisQ36591359
IRF4 addiction in multiple myelomaQ36891060
MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphomaQ37186470
Pathogenesis of classical and lymphocyte-predominant Hodgkin lymphomaQ37463052
Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma.Q37469613
Specificity through cooperation: BATF-IRF interactions control immune-regulatory networksQ38115966
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic targetQ38326252
Gene expression profiling reveals a highly specialized genetic program of plasma cellsQ38358380
A multicolor panel of novel lentiviral "gene ontology" (LeGO) vectors for functional gene analysis.Q38514169
Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.Q38887338
Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphomaQ38943591
PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomasQ39259618
P433issue1
P921main subjectHodgkin lymphomaQ209369
P304page(s)92-101
P577publication date2017-06-29
P1433published inLeukemiaQ6534498
P1476titleAn oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma
P478volume32

Reverse relations

cites work (P2860)
Q59357963Contribution of Epstein⁻Barr Virus Latent Proteins to the Pathogenesis of Classical Hodgkin Lymphoma
Q52718917Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation model.
Q96576631Genomic deregulation of PRMT5 supports growth and stress tolerance in chronic lymphocytic leukemia
Q64917080Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells.
Q49186472IRF4 Mediates the Oncogenic Effects of STAT3 in Anaplastic Large Cell Lymphomas.
Q95936602Intestinal epithelium-derived BATF3 promotes colitis-associated colon cancer through facilitating CXCL5-mediated neutrophils recruitment
Q64076640Investigating the Role of BATF3 in Grass Carp () Immune Modulation: A Fundamental Functional Analysis
Q52585070MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling.
Q46210826New developments in the pathology of malignant lymphoma: a review of the literature published from May to August 2017.
Q45066703S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells
Q52806518The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Q54117760The Pathological Spectrum of Systemic Anaplastic Large Cell Lymphoma (ALCL).
Q52337767The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas.
Q58099160The c-Jun and JunB transcription factors facilitate the transit of classical Hodgkin lymphoma tumour cells through G

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