Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats

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Comparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S002040050061
P698PubMed publication ID8067894

P2093author name stringH P van Helden
R W Busker
J J Zijlstra
H J van der Wiel
B P Melchers
P2860cites workGanglion blocking properties of some bispyridinium soman antagonistsQ39292559
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Ion channel blockade by oximes and recovery of diaphragm muscle from soman poisoning in vitroQ41968097
Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned ratsQ43461803
HI-6 therapy of soman and tabun poisoning in primates and rodentsQ43981556
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Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivationQ44576112
Kinetics, distribution, and biotransformation of the chemical HI-6 in the rat, dog, and rhesus monkeyQ44810060
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PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoningQ46775506
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Reversible and irreversible inhibition of rat brain muscarinic receptors is related to different substitutions on bisquaternary pyridinium oximesQ48449415
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Competitive binding of the oximes HI-6 and 2-PAM with regional brain muscarinic receptorsQ48465329
Kinetic profile in blood and brain of the cholinesterase reactivating oxime HI-6 after intravenous administration to the rat.Q48718735
Organophosphate poisoning: a method to test therapeutic effects of oxamines other than acetylcholinesterase activation in the ratQ48829988
Quantitative structure-activity relationships and possible mechanisms of action of bispyridinium oximes as antidotes against pinacolyl methylphosphonofluoridate.Q52523362
The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including manQ53948958
Toxicology and pharmacology of bispyridium oximes--insight into the mechanism of action vs Soman poisoning in vivo.Q53949613
The interaction of bis-pyridinium oximes with mouse brain muscarinic receptor.Q53963601
A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodentsQ67326616
Efficacy of HLö-7 and pyrimidoxime as antidotes of nerve agent poisoning in miceQ68008588
Acetylcholinesterase reactivators modify the functional properties of the nicotinic acetylcholine receptor ion channelQ69026120
comparison of the efficacy of HS-6 versus HI-6 when combined with atropine, pyridostigmine and clonazepam for soman poisoning in the monkeyQ71428358
Effects of the bispyridinium compounds HGG12, HGG42, and obidoxime on synaptic transmission and NAD(P)H-fluorescence in the superior cervical ganglion of the rat in vitroQ72905012
ANTIDOTAL ACTION OF PYRIDINIUM OXIMES IN ANTICHOLINESTERASE POISONING; COMPARATIVE EFFECTS OF SOMAN, SARIN, AND NEOSTIGMINE ON NEUROMUSCULAR FUNCTIONQ76616153
TOXOGONIN IN SARIN, SOMAN AND TABUN POISONINGQ78334573
P433issue4
P921main subjectpharmacokineticsQ323936
P304page(s)224-230
P577publication date1994-01-01
P1433published inArchives of ToxicologyQ635837
P1476titleComparison of the therapeutic effects and pharmacokinetics of HI-6, HLö-7, HGG-12, HGG-42 and obidoxime following non-reactivatable acetylcholinesterase inhibition in rats
P478volume68

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cites work (P2860)
Q50229391Evaluation of the benefit of the bispyridinium compound MB327 for the antidotal treatment of nerve agent-poisoned mice
Q38137691Neurotranmission systems as targets for toxicants: a review
Q72158204Non-reactivating effects of HI-6 on hippocampal neurotransmission
Q48655118Pharmacokinetics and effects of HI 6 in blood and brain of soman-intoxicated rats: a microdialysis study
Q102206284Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride Co-formulation against VX in a Guinea pig model
Q52187814Subchronic physostigmine pretreatment in guinea pigs: effective against soman and without side effects.
Q42624321Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?

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